2015
DOI: 10.1038/nn.4013
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An astrocyte-dependent mechanism for neuronal rhythmogenesis

Abstract: ABSTRACT:Communication between neurons rests on their capacity to change their firing pattern to encode different messages. For several vital functions, such as respiration and mastication, neurons need to generate a rhythmic firing pattern. Here we show in the rat trigeminal sensori-motor circuit for mastication that this ability depends on regulation of the extracellular Ca 2+ concentration ([Ca 2+ ] e ) by astrocytes. In this circuit, astrocytes respond to sensory stimuli that induce neuronal rhythmic act… Show more

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Cited by 140 publications
(197 citation statements)
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References 49 publications
(49 reference statements)
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“…Whereas the expression of NMDARs and L-VGCCs in astrocytes has been debated, our study is in line with previous studies reporting of the presence of these channels in astrocytes (43)(44)(45)(46)(47)(48)50). With respect to astrocyte NMDARs, we find that applying NMDA in the presence of TTX to prevent synaptic transmission directly triggers astrocyte membrane depolarization, and this depolarization is compromised by intracellularly infusing MK-801 or deleting GRIN1 in astrocytes.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…Whereas the expression of NMDARs and L-VGCCs in astrocytes has been debated, our study is in line with previous studies reporting of the presence of these channels in astrocytes (43)(44)(45)(46)(47)(48)50). With respect to astrocyte NMDARs, we find that applying NMDA in the presence of TTX to prevent synaptic transmission directly triggers astrocyte membrane depolarization, and this depolarization is compromised by intracellularly infusing MK-801 or deleting GRIN1 in astrocytes.…”
Section: Discussionsupporting
confidence: 92%
“…5A), we observed a large and slow depolarization of the astrocyte membrane potential (peak depolarization, 30.67 ± 0.59 mV, n = 12; Fig. 5 C and D), which was in agreement with previous studies (46,50). In addition, observation of the NMDA response despite of the low resting astrocyte membrane potential and in the presence of 1.5 mM extracellular Mg 2+ was reminiscent of the weak Mg 2+ block found for NMDARs expressed by cortical astrocytes (54).…”
Section: Activation Of Astrocyte Nmdars Depolarizes Astrocyte Membranesupporting
confidence: 93%
“…S100-induced modifications of intracellular Ca 2+ in astrocytes (Barger and Van Eldik, 1992) and in neurons by activation of RAGE receptors (Huttunen et al, 2000) appear to be involved in the modulation of synaptic plasticity. S100β released by astrocytes may also promotes changes in neuronal rhythms that are relevant for seizure onset (Morquette et al, 2015;Sakatani et al, 2008), and RAGE receptors areimplicated in both cognitive impairments (Mazarati et al, 2011) and epileptogenesis (Iori et al, 2013). In this context, there is increasing evidence that activated astrocytes play a key role in neuronal network hyperexcitability underlying seizures (Devinsky et al, 2013;Robel et al, 2015).…”
Section: Accepted M Manuscriptmentioning
confidence: 99%
“…Beyond species differences in channels, differences in intracellular or extracellular regulation of Ca 2+ levels by intracellular mechanisms or astrocytes (e.g. Morquette et al, 2015) could affect circuit properties.…”
Section: Intrinsic Cellular Contributions: Ion Channels and Membrane mentioning
confidence: 99%