Neue Kooperationsformen und regionale Identitäten

Synthesis of 4‐(2‐Amino)ethoxy‐3′,4′‐dihydroxychalcones and Their Antioxidant and Cytotoxic Effects on Human Tumor Cells

“…Diverse substituted chalcones have been synthesized to enhance their anticancer activities, and many mechanisms of action of chalcones on anticancer activities have been identified, including the inhibition of tubulin polymerization, inhibition of angiogenesis, and induction of apoptosis. 12 Recent structure-activity relationship studies also proposed that the presence of amino, boronic acid, hydroxyl, or methoxy groups could increase their anticancer activities. 8 In the present study, we aimed at the synthesis of antioxidative chalcones as anticancer agents, which also possess enhanced aqueous solubility.…”

Synthesis of Potential Biologically Active 4,5-Dimethoxy-2- [3-oxo-3-phenylprop-1-en-1-yl]benzene Sulfonic Acid Derivatives

“…Chalcones naturally occur in different plant species like Angelica, Glycyrrhiza, Humulus and Scutellaria and constitute an important class of flavonoid family. These possess a wide spectrum of biological activities, including antibacterial, antifungal 3 , antiinflammatory 4 , antitumor 5 and antimutagenic 6 . Such compounds have also been found active for the inhibition of chemical mediator's release 7 , leukotriene B4 8 , nitric oxide 9 , tyrosinases 10 and aldose reductase activities 11 .…”