Synthesis of 4‐(2‐Amino)ethoxy‐3′,4′‐dihydroxychalcones and Their Antioxidant and Cytotoxic Effects on Human Tumor Cells

Abstract

Aminoethyl‐substituted chalcones 3 exhibiting potent 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical and superoxide anion radical scavenging activities and lipid peroxidation inhibitory activities along with cytotoxicities on four human tumor cells tested.

Hydroxy Chalcones and Analogs with Chemopreventive Properties

“…Aminoalkyl-substituted 3,4,4′-trihydroxychalcone chalcones of type 38 ( Table 3 ) have been designed as compounds with antioxidant and anticancer properties [ 92 ]. These are related to luteolin as a ring-opened analog.…”

Antibacterial activity of a new monocarbonyl analog of curcumin MAC 4 is associated with divisome disruption

“…The catechol nature of MAC 4 was a barrier to its synthesis by aldol condensation reactions. Thus, the methoxymethyl group (MOM) was required to protect the free hydroxyl groups of respective 3,4-dihydroxybenzaldehyde [41,42]. Benzylideneacetone (1) was used as starting material and three steps were necessary to synthesize MAC 4 using synthetic route B (Fig.…”

Hydroxyl‐ and Halogen‐containing Chalcones for the Inhibition of LPS‐stimulated ROS Production in RAW 264.7 Macrophages: Design, Synthesis and Structure–Activity Relationship Study

“…It consists of two aryl rings that are linked by α,β‐unsaturated ketone bridge which allow structural modification to design novel bioactive compounds. Its simple structure, low molecular weight, synthetic chemistry, and broad pharmacological importance such as anticancer, antioxidant, antibacterial, antifungal, antiviral, and anti‐inflammatory effect have increased scientific interest in the field of drug discovery. Many studies on natural, semi‐synthetic, and synthetic chalcone analogs have reported their significant anti‐inflammatory activity that inhibit potential targets, such as prostaglandins (PGs), lipoxygenase (LOX), cyclooxygenase (COX), interleukins (IL), leukotriene D 4 (LTD 4 ), and nitric oxide synthase (NOS) …”