Network pharmacology study reveals energy metabolism and apoptosis pathways-mediated cardioprotective effects of Shenqi Fuzheng

Liao, Jie; Cui, Hao; Huang, Weichao; Shao, Xin; Song, Yangang; Liu, Liangfeng; Ni, Ai; Fan, Xiaohui

doi:10.1016/j.jep.2018.08.029

Cited by 31 publications

(13 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chinese Medicines (CMs), a long history system of medicine with distinct features of theories and practices, has been used for thousands of years (Qiu, 2015). CMs prescriptions embody the principles of system theory, and act on multiple cellular targets in multiple pathways to exert therapeutic effects (Hou et al, 2016;Liao et al, 2018). belongs to the category of pestilence or epidemic in CM (Li et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Identifying potential treatments of COVID-19 from Traditional Chinese Medicine (TCM) by using a data-driven approach

Ren

Shao

et al. 2020

Journal of Ethnopharmacology

108

View full text Add to dashboard Cite

Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

show abstract

Section: Introductionmentioning

confidence: 99%

Identifying potential treatments of COVID-19 from Traditional Chinese Medicine (TCM) by using a data-driven approach

Ren

Shao

et al. 2020

Journal of Ethnopharmacology

108

View full text Add to dashboard Cite

show abstract

“…), genes (Zhou 2020), RNAs (miR-NAs Xu et al (2019, lncRNAs (Lin et al, 2019, etc. ), proteins Shao et al (2016), signaling pathways (Liao et al, 2018), or key cells (Mittal et al, 2019), etc. However, more and more researchers in science community have realized the importance of cell-cell communication during biological processes.…”

Section: Current Applicationsmentioning

confidence: 99%

New avenues for systematically inferring cell-cell communication: through single-cell transcriptomics data

et al. 2020

Self Cite

View full text Add to dashboard Cite

For multicellular organisms, cell-cell communication is essential to numerous biological processes. Drawing upon the latest development of single-cell RNA-sequencing (scRNA-seq), high-resolution transcriptomic data have deepened our understanding of cellular phenotype heterogeneity and composition of complex tissues, which enables systematic cell-cell communication studies at a single-cell level. We first summarize a common workflow of cell-cell communication study using scRNA-seq data, which often includes data preparation, construction of communication networks, and result validation. Two common strategies taken to uncover cell-cell communications are reviewed, e.g., physically vicinal structure-based and ligand-receptor interaction-based one. To conclude, challenges and current applications of cell-cell communication studies at a single-cell resolution are discussed in details and future perspectives are proposed.

show abstract

“…By upregulating the expression of PPARα and PPARγ, Shen-Qi-Fu-Zheng Injection extracted from Codonopsis affinis Hook.f. & Thomson (Dangshen) and Radix Astragali (Huangqi), can interfere with the metabolic process of the injury, inhibit ischemic cardiac structural and functional disorders such as myocardial hypertrophy and VR, effectively improve the damaged cardiac function, and achieve the protective effect of ischemia/reperfusion injury (134). Qi-Li-Qiang-Xin can improve cardiac energy metabolism by up-regulating PGC-1α and PPARγ, which alleviate myocardial hypertrophy and cardiac remodeling, and significantly improve cardiac function, including ejection fraction and fraction shortening (135)(136)(137)(138).…”

Section: Pparγmentioning

confidence: 99%

Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling

Zhu

Liang

2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Ventricular remodeling is related to the renin-angiotensin-aldosterone system, immune system, and various cytokines involved in inflammation, apoptosis, and cell signal regulation. Accumulated studies have shown that traditional Chinese medicine can significantly inhibit the process of ventricular remodeling, which may be related to the mechanism mentioned above. Here, we conducted a system overview to critically review the cellular and molecular mechanism of traditional Chinese medicine on ventricular remodeling. We mainly searched PubMed for basic research about the anti-ventricular remodeling of traditional Chinese medicine in 5 recent years, and then objectively summarized these researches. We included more than 25 kinds of Chinese herbal medicines including Qi-Li-Qian-Xin, Qi-Shen-Yi-Qi Pill, Xin-Ji-Er-Kang Formula, and Yi-Qi-Wen-Yang Decoction, and found that they can inhibit ventricular remodeling effectively through multi-components and multi-action targets, which are promoting the clinical application of traditional Chinese medicine.

show abstract

Network pharmacology study reveals energy metabolism and apoptosis pathways-mediated cardioprotective effects of Shenqi Fuzheng

Cited by 31 publications

References 52 publications

Identifying potential treatments of COVID-19 from Traditional Chinese Medicine (TCM) by using a data-driven approach

Identifying potential treatments of COVID-19 from Traditional Chinese Medicine (TCM) by using a data-driven approach

New avenues for systematically inferring cell-cell communication: through single-cell transcriptomics data

Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling

Contact Info

Product

Resources

About