Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling

Abstract

Ventricular remodeling is related to the renin-angiotensin-aldosterone system, immune system, and various cytokines involved in inflammation, apoptosis, and cell signal regulation. Accumulated studies have shown that traditional Chinese medicine can significantly inhibit the process of ventricular remodeling, which may be related to the mechanism mentioned above. Here, we conducted a system overview to critically review the cellular and molecular mechanism of traditional Chinese medicine on ventricular remodeling. We mainly searched PubMed for basic research about the anti-ventricular remodeling of traditional Chinese medicine in 5 recent years, and then objectively summarized these researches. We included more than 25 kinds of Chinese herbal medicines including Qi-Li-Qian-Xin, Qi-Shen-Yi-Qi Pill, Xin-Ji-Er-Kang Formula, and Yi-Qi-Wen-Yang Decoction, and found that they can inhibit ventricular remodeling effectively through multi-components and multi-action targets, which are promoting the clinical application of traditional Chinese medicine.

Guanxin V alleviates ventricular remodeling by promoting transforming growth factor-beta 1-mediated proteasomal degradation of Vimentin

“…Ventricular remodeling is the main factor determining the incidence of adverse cardiovascular events and long-term prognosis ( Konstam et al, 2011 ). Ventricular remodeling often presents as asymptomatic structural and/or functional abnormalities before patients develop clinical symptoms of heart failure ( Zhu et al, 2021 ). Preventing, suppressing, slowing, or even reversing ventricular remodeling to reduce the risk of heart failure and death is the main intervention target for ventricular remodeling.…”

Dihydromyricetin ameliorates osteogenic differentiation of human aortic valve interstitial cells by targeting c-KIT/interleukin-6 signaling pathway

“…Increasing evidence shows that traditional Chinese herbal medicines have protective and curative pharmacological effects on cardiovascular diseases ( Zhao et al, 2020 ; Zhang et al, 2021a ; Zhang et al, 2021b ; Zhu et al, 2021 ). Ampelopsis grossedentata (also known as vine tea) is a traditional Chinese edible herb widely consumed not only as a healthy tea but also as a medicinal herb that possesses numerous pharmacological activities.…”