Guanxin V alleviates ventricular remodeling by promoting transforming growth factor-beta 1-mediated proteasomal degradation of Vimentin

Gu, Ning; Liang, Bo

doi:10.1016/j.psj.2023.103026

Cited by 1 publication

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Transforming growth factor (TGF) is a cytokine with numerous functions that regulates and takes part in a variety of biological and pathological events in the heart. Saljic et al (2022) , Gu and Liang, (2023) , Liang et al (2022) , Ren et al (2023) , Alex et al (2023) , Dong et al (2023) . To protect the heart, the TGF-β signaling system controls apoptosis, autophagy, and antifibrotic activities ( Deng et al, 2019 ; Shen et al, 2020a ; Liang et al, 2022 ).…”

Section: Cardiovascular Disease-related Signal Pathwaysmentioning

confidence: 99%

Effects of scutellarin on the mechanism of cardiovascular diseases: a review

Zhang,

Yin,

Wang

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Cardiovascular diseases represent a significant worldwide problem, jeopardizing individuals’ physical and mental wellbeing as well as their quality of life as a result of their widespread incidence and fatality. With the aging society, the occurrence of Cardiovascular diseases is progressively rising each year. However, although drugs developed for treating Cardiovascular diseases have clear targets and proven efficacy, they still carry certain toxic and side effect risks. Therefore, finding safe, effective, and practical treatment options is crucial. Scutellarin is the primary constituent of Erigeron breviscapus (Vant.) Hand-Mazz. This article aims to establish a theoretical foundation for the creation and use of secure, productive, and logical medications for Scutellarin in curing heart-related illnesses. Additionally, the examination and analysis of the signal pathway and its associated mechanisms with regard to the employment of SCU in treating heart diseases will impart innovative resolving concepts for the treatment and prevention of Cardiovascular diseases.

show abstract