Nephroprotective activity ofMacrothelypteris oligophlebiarhizomes ethanol extract

Wu, Guanghua; Cai, Yangyang; Han, Wei; Wei, Anhua; Xiong, Chaomei; Fu, Wei; Ruan, Jinlan

doi:10.3109/13880209.2011.632776

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…Another study has proven that use of selenium and garlic in rats resulted in a decrease in the level of BUN and creatinine as compared to the toxic control group (16). These results are parallel to another research study in which the level of BUN and creatinine was significantly (p < 0.05) reduced as compared to the toxic group due to the administration of ethanolic extract of the herbal plant Macrothelypteris oligophlebia in rats (17).…”

Section: Histopathologysupporting

confidence: 83%

“…Previous studies have also shown that antioxidant properties of A barbadensis decrease oxidative stress by decreasing the activity of MDA and increasing the activity of catalase (22). These results are parallel to the study by Wu et al in which use of Macrothelypteris oligophlebia rhizomes produced nephroprotective and antioxidant effects by decreasing the level of MDA and increasing the level of catalase as compared to the toxic control group (17). Aloe barbadensis produced significant positive results at different graded doses.…”

Section: Histopathologysupporting

confidence: 78%

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Nephroprotective Effect of the Leaves of Aloe barbadensis (Aloe Vera) against Toxicity Induced by Diclofenac Sodium in Albino Rabbits

Iftkhar

Sarfraz

et al. 2016

West Indian Med J

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Section: Histopathologysupporting

confidence: 83%

Section: Histopathologysupporting

confidence: 78%

Nephroprotective Effect of the Leaves of Aloe barbadensis (Aloe Vera) against Toxicity Induced by Diclofenac Sodium in Albino Rabbits

Iftkhar

Sarfraz

et al. 2016

West Indian Med J

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“…CCl4 also affects renal antioxidant enzymes defences such as glutathione peroxidase (GPX), catalase (CAT), superoxide dismutase (SOD), glutathione stransferase (GST), glutathione-disulfide reductase (GSR), and quinone reductase (QR) lead reactive oxidative stress (ROS) in renal. This ROS leads to tubular necrosis (Aly et al, 2017;Khan et al, 2010;Wu et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective effect of extract Etlingera elatior (Jack) R.M. Smith on CCl4-induced nephrotoxicity in rats

Fristiohady¹,

Wahyuni²,

Ilyas³

et al. 2020

crbb

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Reactive oxidative stress (ROS) can lead to cell damage, and one of them is the kidney's cell.Etlingera elatior (Jack) R.M. Smith can be utilized as an agent that can protect the cell from ROS. This study aimed to investigate the protective effect of E. elatior fruit on the kidney's cell. We used experimental animals which were treated with Na-CMC (Group I), Na-CMC (Group II), the extracts of E. elatior fruit 200, 300, 400 mg/kg BW for Group III, IV, and V, respectively, for seven days. The blood was collected after treatment. At day 8, group I, III, IV, and V were induced by CCl4. At day 9, blood was collected and the kidneys were harvested for histopathology analysis. Blood collected were measured for albumin, total protein, urea and creatinine levels. After treatment, albumin and total protein showed no increased levels; urea decreased at doses of 200, 300, and 400 mg/kg BW, respectively, and creatinine levels only decreased at the dose of 400 mg/kg BW (p<0.05). The dose of 200 and 300 mg/kg BW showed protecting effects in the tubular cells of renal. Therefore, the ethanol extract of E. elatior showed a nephroprotective effect by normalizing the urea and creatinine levels of rats and protecting tubular cells of renal.

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“…Ascorbic acid was used as the standard drug to compare with a test sample of extract. The percentage of inhibition was subsequently measured and calculated 42 .…”

Section: Nitric Oxide Radical Scavenging Activity 41mentioning

confidence: 99%

Exploring Nephroprotective Properties of Wedelia chinensis: In Vitro, In Silico, and In Vivo Investigations

Gautam,

Venkatachalam,

Senthilkumar

2024

JNR

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The purpose of this research work is to investigate the nephroprotective efficacy of Wedelia chinensis leaf extracts against gentamicin-induced nephrotoxicity for in vitro, in silico, and in vivo techniques. The extracts of Wedelia chinensis leaf rich in flavonoids were subjected to an in silico method for ligands and target proteins. The results of the in vitro antioxidant study of extracts were tested for cytoprotective MTT assay and anti-inflammatory efficacy by protein denaturation assay using Human Embryonic Kidney cells (HEK293). The in vivo nephroprotective potential of the extract was evaluated with the two doses of 250mg/kg and 500mg/kg body weight in gentamicin nephrotoxicity in rats. The biochemical parameters observed for changes in the histopathology of the kidney. While comparing with other extracts of Wedelia chinensis Hydroalcoholic Extract (WCHAE) shows great binding affinity with bonding interactions of flavonoids and phenolics-based ligands observed with the target proteins that provided early information. The in vitro cell lines study revealed no cytotoxicity and better anti-inflammatory effect on HEK293 cells with cytoprotective and nephroprotective efficacy of WCHAE. The in vivo nephroprotective activity improved at a dose of 500mg/kg of WCHAE than Wedelia chinensis Ethanolic Extract (WCEE). The histopathological findings revealed the improvement in gentamicin-induced renal toxicity by the WCHAE orally treated group compared to normal and negative control groups. These results of WCHAE are more satisfactorily effective than WCEE with marked in vitro antioxidant, and cytoprotective effects in HEK293 cells. In in silico docking, it shows good interaction scores of ligands for target proteins like (kidney injury molecule) KIM-1 and Neutrophil Gelatinase-Associated Lipocalin (NAGAL) that helps to correlate nephroprotective potential benefits of antioxidants in plant extracts against gentamicin induced nephrotoxicity in rats.

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Nephroprotective activity ofMacrothelypteris oligophlebiarhizomes ethanol extract

Cited by 7 publications

References 31 publications

Nephroprotective Effect of the Leaves of Aloe barbadensis (Aloe Vera) against Toxicity Induced by Diclofenac Sodium in Albino Rabbits

Nephroprotective Effect of the Leaves of Aloe barbadensis (Aloe Vera) against Toxicity Induced by Diclofenac Sodium in Albino Rabbits

Nephroprotective effect of extract Etlingera elatior (Jack) R.M. Smith on CCl4-induced nephrotoxicity in rats

Exploring Nephroprotective Properties of <i>Wedelia chinensis: In Vitro, In Silico,</i> and <i>In Vivo</i> Investigations

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