Nephroprotective Effect of the Leaves of Aloe barbadensis (Aloe Vera) against Toxicity Induced by Diclofenac Sodium in Albino Rabbits

Iftkhar, A; Ij, Hasan; Sarfraz, Maliha; Jafri, Laila; Ashraf, Muhammad Aleem

doi:10.7727/wimj.2016.052

Cited by 14 publications

(15 citation statements)

References 15 publications

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“…In a study of the effects of AV gel against oxidative stress-induced liver damage, it was determined that AV reduced the formation of lipid peroxidation [28]. Also, when the effects of AV were examined on nephrotoxicity in rabbits, it was determined to have increased the total antioxidant status, reduced the total oxidant status, and increased serum catalase levels due to increased doses of AV [29]. AV has favorable effects on the antioxidant enzyme levels of streptozotocin-induced diabetes in rats.…”

Section: Discussionmentioning

confidence: 99%

The Hepatoprotective Effect of Aloe Vera on Ischemia-Reperfusion Injury in Rats

Şehitoğlu

Karaboğa

Kiraz

et al. 2018

North Clin Istanbul

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OBJECTIVE:Aloe vera is known for its antioxidant properties. In this experimental study, we aimed to investigate the efficacy of Aloe vera in ischemia-reperfusion (I/R) liver injury in rats.METHODS:Male Wistar Albino rats were divided into three groups, where the sham group (n=7) underwent no medication or surgical procedures, the I/R group (n=7) was the control group that received 45 minutes of applied abdominal aorta ischemia and rats were sacrificed 24 hours after reperfusion, and the I/R+AV group (n=7) was the treatment group that was given Aloe vera (30 mg/kg) every day followed by gastric lavage for a month before applying ischemia and performing sacrifice as in the previous group. Before sacrifice, all the liver tissues were removed. Tissues were examined for histopathological investigation, iNOS immunoreactivity and tissue biochemistry, malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities.RESULTS:The SOD, CAT, and GSH-Px levels of the I/R+AV group were not significantly different from the sham group (p>0.05) but were significantly higher when compared to the I/R group. MDA levels of liver tissues were significantly lower (p<0.05) in the I/R+AV group as compared to the I/R group. Disrupted hepatic cords, sinusoidal dilatation, hemorrhage, cytoplasmic vacuolization of hepatocytes, and intensive iNOS immunoreactivity were detected in the I/R group. Decreased histopathological change score and iNOS immunoreactivity score were noticed in the I/R+AV group as compared to the I/R group.CONCLUSION:It was found that Aloe vera showed a hepatoprotective effect against I/R injury. Further research is required to determine the effective dose, administration method, and effects of Aloe vera for liver transplantation.

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Section: Discussionmentioning

confidence: 99%

The Hepatoprotective Effect of Aloe Vera on Ischemia-Reperfusion Injury in Rats

Şehitoğlu

Karaboğa

Kiraz

et al. 2018

North Clin Istanbul

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“…It is revealed that it has conspicuous pharmacological activities such as antibacterial (Subramanian et al, 2006;Arunkumar and Muthuselvam, 2009;Saritha et al, 2010;Fani and Kohanteb, 2012;Nejatzadeh-Barandozi, 2013), antifungal (Bajwa et al, 2007;Rosca-Casian et al, 2007;Khaing, 2011;Sitara et al, 2011), antiviral (Zandi et al, 2007), antioxidant (Baradaran et al, 2013;Ray et al, 2013;Kang et al, 2014), cytotoxic (Jose et al, 2014;Shalabi et al, 2015), antidiabetic (Tanaka et al, 2006;Choudhary et al, 2014;Suleyman et al, 2014), anti-inflammatory (Vijayalakshmi et al, 2012;Bhattacharjee et al, 2014), antitumor (El-Shemy et al, 2010;Srihari et al, 2015), nephroprotective (Iftikhar et al, 2015;Virani et al, 2016), antiulcer (Borra et al, 2011) and anti-aging effects which can be used as a moisturizing agent to cure cardiovascular diseases as well as to enhance the immune system (Chatterjee et al, 2013). It is used as an herbal medicine since long time which contains more than 100 bioactive constituents.…”

Section: Issn: 2319-7706 Volume 6 Number 3 (2017) Pp 2152-2162mentioning

confidence: 99%

Antimicrobial Activity and Phytochemical Screening of Aloe vera (Aloe barbadensis Miller)

Dharajiya¹,

Patel²

2017

Int.J.Curr.Microbiol.App.Sci

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“…When there is an autoimmune attack against the attachment proteins of keratinocytes, they undergo apoptosis and stimulate several subsequent pathological events. For example, in psoriasis, activated T lymphocytes release various cytokines to stimulate the proliferation of keratinocytes (38). Cytokine-activated keratinocytes can also express a broad array of cytokines, chemokines, and membrane molecules that induce the recruitment and activation of T lymphocytes in the skin (39)(40)(41).…”

Section: Discussionmentioning

confidence: 99%

Th22 Cells Promote in vitro Proliferation and Cytokine Secretion in HaCaT and HRMC cells via Production of IL-22 and Stimulation of PI3K/AKT Signaling

Zhao¹,

Sun²,

Liu³

et al. 2020

Preprint

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Background: T helper (Th) 22 cells function in the pathogenesis of systemic lupus erythematosus (SLE), but their exact role remains unclear. We examined in vitro interactions of Th22 cells with different target cells.Methods: Flow cytometry was used to isolate Th22 cells from the peripheral blood mononuclear cells (PBMCs) of 5 healthy subjects. The optimal co-culture ratio of effector:target (E:T) cells and the optimal co-culture concentration of recombinant interleukin (rIL) -22 were determined. The levels of IL-22, proliferation of target cells, and the levels proinflammatory cytokines in different culture systems with human keratinocyte cells (HaCaT) and human renal mesangial cells (HRMC) were determined. Western blotting was used to assess changes in the levels of proteins in the PI3K/AKT pathway.Results: The levels of IL-22 were greater when HaCaT and HRMC cells were co-cultured with Th22 cells or rIL-22, and co-culturing with contact had a greater effect than co-culturing without contact. The levels of cytokines were also significantly greater when target cells were co-cultured with Th22 cells. IL-22mAb reversed the effect of IL-22. Th22 cells significantly activated PI3K/AKT signaling in HaCaT and HRMC cells; LY294002 (an inhibitor of this pathway) reversed this effect and also downregulated the levels of proinflammatory cytokines; IL-22mAb had a similar but weaker effect. Conclusions: Our results suggest that Th22 cells promote cell proliferation and secretion of pro-inflammatory cytokines of their target cells via IL-22-mediated stimulation of PI3K/AKT signaling.

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Nephroprotective Effect of the Leaves of Aloe barbadensis (Aloe Vera) against Toxicity Induced by Diclofenac Sodium in Albino Rabbits

Abstract: These results have shown that can normalize oxidative stress and can be used as an effective nephroprotective agent against drug-induced nephrotoxicity.

Cited by 14 publications

References 15 publications

The Hepatoprotective Effect of Aloe Vera on Ischemia-Reperfusion Injury in Rats

The Hepatoprotective Effect of Aloe Vera on Ischemia-Reperfusion Injury in Rats

Antimicrobial Activity and Phytochemical Screening of Aloe vera (Aloe barbadensis Miller)

Th22 Cells Promote in vitro Proliferation and Cytokine Secretion in HaCaT and HRMC cells via Production of IL-22 and Stimulation of PI3K/AKT Signaling

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