Renal failure is a condition in which the kidneys fail to remove metabolic end-products from the blood and regulate the fluid, electrolyte, and pH balance of the extra cellular fluids. The underlying cause may be renal disease, systemic disease, or urologic defects of non renal origin. Renal failure can occur as an acute or a chronic disorder. Zhanget al.,(2013) Glycerol is sugar alcohol compound. It is a colorless, odorless, viscous liquid that is widely used in pharmaceutical formulations. Glycerol has three hydroxyl groups that are responsible for its solubility in water. The glycerol backbone is central to all lipids known as triglycerides. Glycerol is sweet-tasting and generally considered nontoxic. Glycerol-induced Acute Renal Failure is characterized by myoglobinuria, tubular necrosis. Karam et al.,(1995) .A standard method of inducing renal failure is byintramuscular administration of 50% glycerol, v/v(8 ml/kg, im) Savic et al.,(2002). Citrus aurantium L. (Rutaceae) also called Bitter orange, used as traditional Chinese medicine for more than 5,000 years Castleman,(1995). The application of fruit extract as dietary supplement for losing body weight has recently been developed, with the active constituents as adrenergic amines and flavonoids Kuboet al.,(2005). Bitter orange used in herbal medicine as a stimulant Sharpe et al., (2006), contains the tyramine metabolites Nmethyltyramine, octopamine and synephrine Gange et al., (2006). These substances are similar in action to that of epinephrine, act on the α1 receptors responsible for hypertension Hess and Sullivan, (2005). It had also been reported that C. aurantium has useful effects to control insect pests Siskos et al.,