Nepeta menthoides Boiss. &amp; Buhse freeze-dried aqueous extract versus sertraline in the treatment of major depression: a double blind randomized controlled trial

Kolouri, Sepideh; Firoozabadi, Ali; Salehi, Alireza; Zarshenas, MM; Dastgheib, Seyed Alireza; Heydari, Mojtaba; Rezaeizadeh, Hossein

doi:10.1055/s-0036-1596965

Cited by 5 publications

(5 citation statements)

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“…Current evidence suggests that this is due to hyperforin increasing the expression of the pregnane X receptor, which increases P-glycoprotein expression (the drug efflux pump; Dresser, Schwarz, Wilkinson, & Kim, 2003;Izzo, 2004;Moore et al, 2000). It should be noted that low-dose hyperforin preparations (<4 mg of hyperforin) may not affect P-glycoprotein expression and hence may be safer (Izzo, 2004;Mueller et al, 2006 (Kolouri et al, 2016).…”

Section: Curcuma Longa (Turmeric)mentioning

confidence: 99%

Herbal medicines in the treatment of psychiatric disorders: 10‐year updated review

Sarris

2018

Phytotherapy Research

137

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This paper provides a 10-year update of the 2007 systematic review of herbal medicines studied in a broad range of psychiatric disorders, including depression, anxiety, obsessive-compulsive, seasonal affective, bipolar, psychotic, phobic, somatoform, and attention-deficit hyperactivity disorders. Ovid Medline, PubMed, and the Cochrane Library were searched for herbal medicines with both pharmacological and clinical evidence of psychotropic activity. This updated review now covers clinical trial evidence for 24 herbal medicines in 11 psychiatric disorders. High-quality evidence was found to exist for the use of Piper methysticum (Kava), Passiflora spp. (passionflower) and Galphimia glauca (galphimia) for anxiety disorders; and Hypericum perforatum (St John's wort) and Crocus sativus (saffron) for major depressive disorder. Other encouraging herbal medicines with preliminary evidence include Curcuma longa (turmeric) in depression, Withania somnifera (ashwagandha) in affective disorders, and Ginkgo biloba (ginkgo) as an adjunctive treatment in Schizophrenia. Although depression and anxiety are commonly researched, many other mental disorders still require further prospective investigation. Although the previous review suggested increasing the adjunctive study of select herbal medicines with pharmaceuticals, this was still only found to sparingly occur in research designs. Aside from this, future focus should involve the incorporation of more biomarker analysis, in particular pharmacogenomics, to determine genetic factors moderating response to herbal medicines.

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Section: Curcuma Longa (Turmeric)mentioning

confidence: 99%

Herbal medicines in the treatment of psychiatric disorders: 10‐year updated review

Sarris

2018

Phytotherapy Research

137

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“…In this group, which was examined within 2 weeks after the intervention, a lower relapse rate was detected. As a herbal formulation, the extract can be successfully used to normalize mood in patients with severe depression, since it was established that N. menthoides lyophilized aqueous extract has an antidepressant effect and prevents the relapse of depression [114].…”

Section: Genus Nepeta Lmentioning

confidence: 99%

Members of the family <i>Lamiaceae</i> Lindl. as sources of medicinal plant raw materials to obtain neurotropic drugs

Звездина

Дайронас

Бочкарева

et al. 2020

Farm. farmakol. (Pâtigorsk)

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The aim of this work is to review and analyze the data published in the modern scientific literature obtained in pharmacological, pharmacognostic and pharmacotechnological studies of various types of raw materials obtained from members of the family Lamiaceae L., which were sources of biologically active substances, pharmaceutical substances, total extracts and the drugs – with a neurotropic activity.Materials and methods. For the review, we used the information of scientific literature from open and accessible sources of the last twenty years, located in the scientific and technical libraries of institutions, as well as in electronic databases: Elibrary, PubMed, Scopus, Cyberleninka, GoogleAcademy, J-Stage. The search inquiries were: the species of the family Lamiaceae (Russian and Latin), the samples of medicinal plant materials based on them as well as the names of the drugs and biologically active substances obtained from these raw materials.Results. When working with the sources of scientific information, the main attention was paid to pharmacologic tests performed during the studies on laboratory animals and proving the presence of neurotropic activity in the studied objects – essential oils and extracts from plant raw materials: aqueous, aqueous alcoholic, and methanol ones. It has been established that the potential of the therapeutic and preventive application of pharmaceutical substances and drugs based on the medicinal plant materials obtained from 30 genera members of the Lamiaceae family, remains unrealized despite the close attention of various researchers.Conclusion. This review comprised 71 species from 30 genera. Despite the significant level of the previous study presented in the analysis of this publication, an enormous potential of this family’s species remains unexplored. In the future, they can be of both – pharmacognostic and practical interest, in particular, in creation of new medicinal preparations of the neurotropic action based on them.

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“…On the basis of a structured clinical interview as defined by N. menthoides may be useful in controlling the mood. As this herb causes sustention of antidepressant effect and delay in the recurrence of depression, it could be considered worthwhile (Kolouri et al, 2016).…”

Section: Antidepressant Activitymentioning

confidence: 99%

Pharmacological and chemical features of Nepeta L. genus: Its importance as a therapeutic agent

Süntar

Nabavi

Barreca

et al. 2017

Phytotherapy Research

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Medicinal plants have always had great value for the human population due to their valuable constituents and potential bioactivities. The objective of this review is to present an updated overview of an important medicinal plant genus Nepeta L., from the family Lamiaceae, revealing its traditional utilization, biological activity, phytoconstituents, and mechanisms of action. For this purpose, a literature survey was carried out by using SciFinder, ScienceDirect, Scopus, PubMed, and Web of Science followed by a revision of the bibliographies of the related articles. We have described and analyzed the role of plants in drug discovery and the importance of Nepeta species. Information on the utilization purposes of Nepeta species in folk medicine has been emphasized, and scientific studies on the biological effects and secondary metabolites are addressed. Nepeta species are characterized by terpenoid-type compounds and phenolic constituents, which exert several activities such as an antimicrobial, repellent against major pathogen vector mosquitoes, insecticide, larvicide against Anopheles stephensi, cytotoxic anticarcinogen, antioxidant, anticonvulsant, analgesic, anti-inflammatory agent, and antidepressant, revealing its importance in medicinal and agricultural fields. On the basis of numerous studies, the Nepeta genus demonstrates remarkable therapeutic effects against various diseases. However, clinical studies are warranted to confirm preclinical findings.

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Nepeta menthoides Boiss. & Buhse freeze-dried aqueous extract versus sertraline in the treatment of major depression: a double blind randomized controlled trial

Cited by 5 publications

References 0 publications

Herbal medicines in the treatment of psychiatric disorders: 10‐year updated review

Herbal medicines in the treatment of psychiatric disorders: 10‐year updated review

Members of the family <i>Lamiaceae</i> Lindl. as sources of medicinal plant raw materials to obtain neurotropic drugs

Pharmacological and chemical features of Nepeta L. genus: Its importance as a therapeutic agent

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