The aim of this work is to review and analyze the data published in the modern scientific literature obtained in pharmacological, pharmacognostic and pharmacotechnological studies of various types of raw materials obtained from members of the family Lamiaceae L., which were sources of biologically active substances, pharmaceutical substances, total extracts and the drugs – with a neurotropic activity.Materials and methods. For the review, we used the information of scientific literature from open and accessible sources of the last twenty years, located in the scientific and technical libraries of institutions, as well as in electronic databases: Elibrary, PubMed, Scopus, Cyberleninka, GoogleAcademy, J-Stage. The search inquiries were: the species of the family Lamiaceae (Russian and Latin), the samples of medicinal plant materials based on them as well as the names of the drugs and biologically active substances obtained from these raw materials.Results. When working with the sources of scientific information, the main attention was paid to pharmacologic tests performed during the studies on laboratory animals and proving the presence of neurotropic activity in the studied objects – essential oils and extracts from plant raw materials: aqueous, aqueous alcoholic, and methanol ones. It has been established that the potential of the therapeutic and preventive application of pharmaceutical substances and drugs based on the medicinal plant materials obtained from 30 genera members of the Lamiaceae family, remains unrealized despite the close attention of various researchers.Conclusion. This review comprised 71 species from 30 genera. Despite the significant level of the previous study presented in the analysis of this publication, an enormous potential of this family’s species remains unexplored. In the future, they can be of both – pharmacognostic and practical interest, in particular, in creation of new medicinal preparations of the neurotropic action based on them.
Перспективными источниками биологически активных веществ (БАВ), обладающих нейротропной активностью, являются представители рода Nepeta L. - котовник кошачий (Nepeta cataria L.) и котовник крупноцветковый (Nepeta grandiflora Bieb.). Цель - изучение в эксперименте in vivo и in vitro фармакологической активности экстрактов и фракций БАВ котовника кошачьего и котовника крупноцветкового. Методика. Для сравнительной оценки нейротропной активности экстрактов котовников кошачьего (Nepeta cataria L.) и крупноцветкового (Nepeta grandiflora Bieb.) проведен биологический скрининг образцов, обладающих дофаминергической активностью с применением тирозингидроксилазной специфической ферментной биотест-системы в условиях in vitro. Определение параметров острой токсичности и противовоспалительной активности экстракта проводили в экспериментах in vivo. Для оценки острой токсичности экстракта по методу Кербера использованы белые нелинейные мыши-самцы. Экстракты вводили животным внутрижелудочно в дозах 500, 1000, 1500 и 2000 мг/кг. Изучали влияние курсового (3-4 сут) введения выбранных по результатам скрининга экстрактов (дозы 10 и 100 мг/кг) на центральную нервную систему и поведение животных на моделях «приподнятый крестообразный лабиринт» и «хлоралгидратный сон». Препаратом сравнения служил экстракт пустырника (100 мг/кг). Результаты. В результате проведенных скрининговых исследований в условиях опытов in vitro с применением специфической ферментной биотест-системы на основе тирозингидроксилазы выявлена дофаминергическая активность у котовника крупноцветкового экстракта сухого и котовника кошачьего экстракта сухого. При однократном введении экстракты не приводили к гибели животных, изменению внешнего вида и поведенческих реакций мышей. В соответствии с классификацией токсичности химических веществ по ГОСТ 12.1.007-76 экстракты является малотоксичными веществами. В дозах 10 и 100 мг/кг экстракты оказывали статистически значимое седативное действие, снижали нервно-эмоциональное напряжение. Седативное действие проявлялось в ускорении процесса засыпания и увеличении продолжительности сна. Заключение. Выявлена дофаминергическая активность экстрактов котовника крупноцветкового экстракта сухого и котовника кошачьего экстракта сухого. Экстракты котовника кошачьего и котовника крупноцветкового являются малотоксичными веществами, обладают в опытах in vivo выраженным седативным действием, снижают нервно-эмоциональное напряжение. Экстракты котовника кошачьего и котовника крупноцветкового перспективны для дальнейшего изучения. Promising sources of biologically active substances (BAS) with neurotropic activity are representatives of the genus Nepeta L. - cat’s cat (Nepeta cataria L.) and large-flowered cat’s cat (Nepeta grandiflora Bieb.). The aim of the work is to study the pharmacological activity of extracts and fractions of BAS Catnip and large-flowered Catnip with the use of specific enzyme Biotest systems in in vitro experiments and using biological models on laboratory animals. Method. For a comparative assessment of the neurotropic activity of cat extracts (Nepeta cataria L.) and large-flowered (Nepeta grandiflora Bieb.) biological screening of samples with dopaminergic activity was performed using a tyrosine hydroxylase-specific enzyme Biotest system in in vitro experiments. The parameters of acute toxicity and anti-inflammatory activity of the extract were determined. When studying the acute toxicity of the extract using the Kerber method, white non-linear male mice in the number of 30 individuals were used. Extracts were administered to animals intragastrically in doses of 500, 1000, 1500 and 2000 mg/kg. We studied the effect of course (3-4 days) administration of selected extracts based on the results of screening on the Central nervous system and animal behavior at doses of 10 and 100 mg / kg on the models «raised cruciform labyrinth» and «chloral hydrate sleep». Comparison drug-motherwort extract tablets at a dose of 100 mg/kg. Results. As a result of screening studies in in vitro experiments based on tyrosine hydroxylase, dopaminergic activity was detected in the cat’s large-flowered dry extract and cat’s dry cat extract. When administered once, the extracts did not lead to the death of animals, changes in the appearance and behavioral reactions of mice were not observed. According to the chemical toxicity classification according to GOST 12.1.007-76, extracts are low-toxic substances. In doses of 10 mg / kg and 100 mg / kg, these extracts have a significantly pronounced sedative effect, reduce nervous and emotional tension. The sedative effect is shown in improving sleep and increasing the duration of sleep. Conclusions. Dopaminergic activity was detected in the cat’s large-flowered dry extract and the cat’s dry cat extract. Extracts of Catnip and large-flowered Catnip are low-toxic substances, have a pronounced sedative effect in experiments in vivo, reduce nervous and emotional tension. Extracts of Catnip and large-flowered Catnip are promising for further study.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.