Neonicotinoid insecticide exposures reported to six poison centers in Texas

Forrester, Mathias B.

doi:10.1177/0960327114522500

Cited by 40 publications

(42 citation statements)

References 10 publications

(67 reference statements)

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“…The prevalence of voluntary intoxication was diferent from one study to another: only 2% in the study in Texas and 4.9% in the study in France, as opposed to the studies in China and Sri Lanka, where 81% and 82%, respectively, were classiied as an atempt of suicide [25,26,13].…”

Section: Poisoning -From Specific Toxic Agents To Novel Rapid and Simmentioning

confidence: 59%

“…The patient recovered without complications with supportive treatment and was discharged 4 days after ingestion [24]. Most cases were reported in USA (Texas), France, China and Sri Lanka [25,26,13]. The epidemiological aspects resulting from these studies are summarized in Table 3.…”

Section: Epidemiology Of Acute Poisoning With Neonicotinoids In Humansmentioning

confidence: 99%

“…• Second-degree burns >50% BSA to adult and >30% BSA to child dizziness, hypertension and tachycardia [25]. The French Toxicity Co-ordination Commitee analyzed 428 cases of exposure to imidacloprid between 1999 and 2012, of which over 27% were children under 5 years of age.…”

Section: Sri Lankamentioning

confidence: 99%

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Acute Poisoning with Neonicotinoid Insecticide

Nistor¹,

Frăsinariu²,

Ştreangă³

2017

Poisoning - From Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis

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Neonicotinoids are a class of insecticides considered less toxic to humans than organophosphates, carbamates, organochloride and pyrethroids. The purpose of this chapter was to systematize existing data in the literature on acute intoxication with neonicotinoids to help practitioners. Clinical manifestations vary across diferent human systems.Gastrointestinal symptoms consist of nausea, vomiting, abdominal pain and corrosive lesions. In the central nervous system, headaches, agitation, confusion, fasciculations, seizures or coma may occur, while tachycardia or bradycardia, hypertension, hypotension and palpitations occur in the cardiovascular system. Respiratory efects are dyspnea, aspiration pneumonia or respiratory failure. Solvents that drive the insecticide also have an important role in the toxic efects. There are no speciic biological tests of neonicotinoid intoxication, and their dosing is not routinely available. Treatment is symptomatic. Mortality is less than 3%, well below the poisoning with anticholinesterase insecticides, like organophosphates and carbamates.

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Section: Poisoning -From Specific Toxic Agents To Novel Rapid and Simmentioning

confidence: 59%

Section: Epidemiology Of Acute Poisoning With Neonicotinoids In Humansmentioning

confidence: 99%

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Acute Poisoning with Neonicotinoid Insecticide

Nistor¹,

Frăsinariu²,

Ştreangă³

2017

Poisoning - From Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis

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“…The authors although stated (an often shortcoming also observed in other studies) that no data regarding serum IMI level were available. Forrester (2014) provided an overall picture of NNDs exposure that occurred in Texas, USA, from 2000 to 2012. Of 1,142 exposures the 77% contained IMI and in less extent DINOT (17%).…”

Section: Case Reportsmentioning

confidence: 99%

Neonicotinoids and their Metabolites in Human Biomonitoring: A Review

Kasiotis

Machera

2015

Hellenic Plant Protection Journal

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Summary Neonicotinoids (NNDs) constitute a major class of insecticides with a broad and versatile spectrum of applications in agriculture. Hence, their residues are found in several environmental compartments and can be transferred via several pathways to numerous organisms. Despite their profound impact on honeybees and wild bees (impairment of memory, impact on immune system), their presence in humans is far less reported, possibly due to the low to moderate toxicological eff ects that they elicit. The aim of the present review is to emphasize on developments in the biomonitoring of NNDs. It focuses mainly on chromatographic analysis of NNDs and their metabolites in human biological fl uids, discussing key features, such as sample preparation and analytical method validation. Nonetheless, case reports regarding intoxication incidents are presented, highlighting the signifi cance of such cases especially in the developing world.

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“…From a clinical perspective, there were 1142 neonicotinoid exposures reported to poison centers in Texas, USA from 2000 to 2012 [13]; most were associated with products containing imidacloprid (77%) or dinotefuran (17%). Exposure to ACE was associated with only 0.5% of the reported incidents.…”

Section: Introductionmentioning

confidence: 99%

Acetamiprid Accumulates in Different Amounts in Murine Brain Regions

Terayama

Endo

Tsukamoto

et al. 2016

IJERPH

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Neonicotinoids such as acetamiprid (ACE) belong to a new and widely used single class of pesticides. Neonicotinoids mimic the chemical structure of nicotine and share agonist activity with the nicotine acetylcholine receptor (nAchR). Neonicotinoids are widely considered to be safe in humans; however, they have recently been implicated in a number of human health disorders. A wide range of musculoskeletal and neuromuscular disorders associated with high doses of neonicotinoids administered to animals have also been reported. Consequently, we used a mouse model to investigate the response of the central nervous system to ACE treatment. Our results show that exposure to ACE-containing water for three or seven days (decuple and centuple of no observable adverse effect level (NOAEL)/day) caused a decrease in body weight in 10-week old A/JJmsSlc (A/J) mice. However, the treatments did not affect brain histology or expression of CD34. ACE concentrations were significantly higher in the midbrain of ACE-treated mice than that of the normal and vehicle groups. Expression levels of α7, α4, and β2 nAChRs were found to be low in the olfactory bulb and midbrain of normal mice. Furthermore, in the experimental group (centuple ACE-containing water for seven days), β2 nAChR expression decreased in many brain regions. Information regarding the amount of accumulated ACE and expression levels of the acetylcholine receptor in each region of the brain is important for understanding any clinical symptoms that may be associated with ACE exposure.

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Neonicotinoid insecticide exposures reported to six poison centers in Texas

Cited by 40 publications

References 10 publications

Acute Poisoning with Neonicotinoid Insecticide

Acute Poisoning with Neonicotinoid Insecticide

Neonicotinoids and their Metabolites in Human Biomonitoring: A Review

Acetamiprid Accumulates in Different Amounts in Murine Brain Regions

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