Acute Poisoning with Neonicotinoid Insecticide

Nistor, Nicolai; Frăsinariu, Otilia; Ştreangă, Violeta

doi:10.5772/intechopen.72004

Cited by 5 publications

(4 citation statements)

References 35 publications

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“…30, 12 and 6 mg AI/kg b.w., for subacute 28days repeated dose toxicity study. Th e clinical symptoms of TMX observed, in the acute toxicity study, were mostly distinguished within the fi rst 3 h of exposure to high doses of TMX and this is reliable with the known mode of action for neonicotinoids that target Nicotinic Acetylcholine receptor (nAChR) of the postsynaptic membranes from both nerve and muscle cells and thus disrupt the transmission of the nervous infl ux into the central and peripheral nervous system [53]. Th e most observed toxicity signs of TMX reported within the fi rst 2-3 h of administration of TMX included vomiting, nausea, agitation and multiple episodes of generalized tonic-clonic seizures [54].…”

Section: Discussionsupporting

confidence: 53%

Sublethal Toxicity of Thiamethoxam Insecticide in Albino Mice: Biochemical, Oxidative Damage and Histopathological Evaluations

Abouelghar¹,

Yassien²,

El-Bermawy³

et al. 2020

Adv J Toxicol Curr Res

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The Neonicotinoid insecticides are presently used in great amounts, but this can be a problem when the possible risks of occupational and environmental contamination are considered. The objective of this study was to investigate the potential adverse effects of sublethal doses of Thiamethoxam insecticide on serum biochemical, oxidative stress and histological alterations in male albino mice via 28-day repeated-dose oral toxicity study. The possible ameliorative effect of selenium plus vitamin E against the harmful effects of Thiamethoxam was also investigated. Mice in Thiamethoxam-treated groups received three sublethal doses (6, 12, and 30 mg/kg b.w./day). Animals in another group were orally co-administered selenium + vitamin E with the higher dose of insecticide. The results showed that Thiamethoxam significantly (p < 0.05) increased cholesterol levels and liver enzyme activities, in dose-dependent manner, compared to those of the control group. Levels of creatinine were not significantly changed, whereas uric acid increased at high doses. The oxidative stress parameters were significantly increased in association with decrease in total antioxidants level. The histological analysis revealed that the higher dose induced various alterations in tissues of vital organs, i.e. liver, kidney, lung and testes. Interestingly, the ameliorative effect of selenium + vitamin E in restoring the oxidative stress parameters was reflected by reducing severity of histopathological lesions. In conclusion, it appears that the sublethal dose < 6.0 mg/kg b.w./day, in repeated dose 28-day oral toxicity study, in male albino mice may be considered as No-Observed-Adverse-Effect-Level (NOAEL) of Thiamethoxam. Additionally, the antioxidant selenium, in mixture with vitamin E, showed an ameliorative effect against Thiamethoxam-induced toxicity.

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Section: Discussionsupporting

confidence: 53%

Sublethal Toxicity of Thiamethoxam Insecticide in Albino Mice: Biochemical, Oxidative Damage and Histopathological Evaluations

Abouelghar¹,

Yassien²,

El-Bermawy³

et al. 2020

Adv J Toxicol Curr Res

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Section: Discussionmentioning

confidence: 99%

“…They also made very short visits to flowers, leaving the sprayed area quickly. This kind of behaviour might be due to the neurotoxic effect of the tested insecticide (Fishel, 2005;Nistor et al, 2017;Schmuck, 1999) and should deserve consideration in future studies. Pecenka et al (2021) showed that insecticide applications can be highly reduced (by 95%) while maintaining or enhancing crop yields through wild pollinator conservation.…”

Section: Effect Of Imidacloprid Spray On Fruit Setmentioning

confidence: 99%

The effects of pesticides on tomato pollinators depend on application practices and floral visitor assemblage

Franceschinelli,

Bergamini,

Paniago

et al. 2023

J Applied Entomology

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Pesticide use affects biodiversity and ecosystem service provision. Yet, such effects may vary between pesticides, dosage, application timing and pollinator assemblage in the study area. Understanding such diversity of effects is essential to enable integrated pest management practices that minimize negative impacts on pollinators. Here, we use a controlled experiment to compare different strategies of pesticide application in tomato crops: no application, low‐intensity applications (every 7 days) and high‐intensity application (every 3–4 days) with the last being the usual practice used by farmers in the study region. We focus on imidacloprid that is a neonicotinoid insecticide commonly used in Brazil. We show the negative effects of imidacloprid on the pollinator visitation rate of tomato flowers varied between flower visitor species. While the bee Paratrigona lineata was negatively affected by the imidacloprid application, no effects were detected when analysing all other bees as a group, indicating a null net effect. Although some studies have shown this insecticide is extremely harmful to bees' health, others showed that some bees do not avoid it, which may explain our results. However, the visitation rate recovery for P. lineata was only detected in the less than the more intensive treatment after imidacloprid applications ceased. The fact that no differences in fruit production were detected between treatments (including control blocks) could result from a null net effect of the negative effects on pollinators and positive effects on pest control. Further studies would be needed to disentangle the two effects.

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“…It causes various skin ailments like rashes and oedema, headache, ocular irritation and lacrimation, diarrhea, vomiting and chronic exposure may lead to cancer [2][3]. Recently, many researchers have reported that interaction of humans to pesticide for a certain time period cause the severe neurophysiological and neurobehavioral abnormalities [4]. Flonicamid is a pyridine carboxamide insecticide, has 4-trifluoromethylnicotinamide (TFNA-AM) as a major metabolic component.…”

Section: Introductionmentioning

confidence: 99%

Appraisal of Acute Oral LD<sub>50</sub> of Flonicamid and Ameliorative Effects of Selected Vitamins on Hepato Toxicity of Exposed Rabbits

Shafiq¹,

Qadir²,

Hussain³

et al. 2022

Pol. J. Environ. Stud.

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Flonicamid is an insecticide which is frequently used in agriculture practices these days. However the excessive use of this chemical insecticide exhibit toxic effects on ecosystem as well as on mammals. Therefore, the present study was conducted to evaluate flonicamid median lethal dose which is 180 mg/kg body weight. Further, investigations involved the repeated oral administration of safe dose of flonicamid i.e 18 mg/kg body weight /day to various groups of rabbits alone, in combination with vitamin C and E for partial sub chronic study of 30 days. Significant increase (P<0.05) in hepatic enzymes such as alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase were observed whereas animal body weight, serum protein and serum albumin exhibited significant decrease (P<0.05) in rabbits given only flonicamid. In addition, histological examination of liver tissues of treated rabbits showed alterations of hepatocytes morphology from severe level to mild depending upon type of treatment either given flonicamid only or co-administered with vitamin C/vitamin E. We conclude that supplementation of vitamin C alone and in combination with vitamin E each at 100 mg/kg body weight/day dose significantly reduces the toxicopathetic effects of flonicamid in exposed rabbits and ameliorates the hepatic marker enzymes as well as histological aspects of liver tissues near the control group.

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Acute Poisoning with Neonicotinoid Insecticide

Cited by 5 publications

References 35 publications

Sublethal Toxicity of Thiamethoxam Insecticide in Albino Mice: Biochemical, Oxidative Damage and Histopathological Evaluations

Sublethal Toxicity of Thiamethoxam Insecticide in Albino Mice: Biochemical, Oxidative Damage and Histopathological Evaluations

The effects of pesticides on tomato pollinators depend on application practices and floral visitor assemblage

Appraisal of Acute Oral LD<sub>50</sub> of Flonicamid and Ameliorative Effects of Selected Vitamins on Hepato Toxicity of Exposed Rabbits

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