Neonicotinoids and their Metabolites in Human Biomonitoring: A Review

Kasiotis, Konstantinos M.; Machera, Kyriaki

doi:10.1515/hppj-2015-0006

Cited by 11 publications

(9 citation statements)

References 62 publications

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“…Imidacloprid, the irst neonicotinoid insecticide discovered in 1994 in Japan, is a structural analogue of nicotine derived from N-nitroguanidine Figure 1. Common names and molecular structures of the neonicotinoids [14]. and is the best sold worldwide.…”

Section: Physicochemical Properties Of Neonicotinoidsmentioning

confidence: 99%

“…and is the best sold worldwide. Currently, besides imidacloprid, the neonicotinoid family includes thiamethoxam, clothianidin, thiacloprid, acetamiprid, dinotefuran, nitenpyram, nitiazine, imidaclothiz, lonicamid, sulfoxalor and cycloxaprid, the chemical structure of which is shown in Figure 1 [14]. Currently, neonicotinoids are homologated in agriculture in more than 120 countries, being sold under various commercial names [14] ( Table 1).…”

Section: Physicochemical Properties Of Neonicotinoidsmentioning

confidence: 99%

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Acute Poisoning with Neonicotinoid Insecticide

Nistor¹,

Frăsinariu²,

Ştreangă³

2017

Poisoning - From Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis

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Neonicotinoids are a class of insecticides considered less toxic to humans than organophosphates, carbamates, organochloride and pyrethroids. The purpose of this chapter was to systematize existing data in the literature on acute intoxication with neonicotinoids to help practitioners. Clinical manifestations vary across diferent human systems.Gastrointestinal symptoms consist of nausea, vomiting, abdominal pain and corrosive lesions. In the central nervous system, headaches, agitation, confusion, fasciculations, seizures or coma may occur, while tachycardia or bradycardia, hypertension, hypotension and palpitations occur in the cardiovascular system. Respiratory efects are dyspnea, aspiration pneumonia or respiratory failure. Solvents that drive the insecticide also have an important role in the toxic efects. There are no speciic biological tests of neonicotinoid intoxication, and their dosing is not routinely available. Treatment is symptomatic. Mortality is less than 3%, well below the poisoning with anticholinesterase insecticides, like organophosphates and carbamates.

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Section: Physicochemical Properties Of Neonicotinoidsmentioning

confidence: 99%

Section: Physicochemical Properties Of Neonicotinoidsmentioning

confidence: 99%

Acute Poisoning with Neonicotinoid Insecticide

Nistor¹,

Frăsinariu²,

Ştreangă³

2017

Poisoning - From Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis

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“…For example, in 2012, sales in Latin America, Asia, and North America accounted for 75% of the global market, while sales in Europe only accounted for 11% [6]. Neonicotinoids have chemical structures similar to nicotine and target the insect’s nicotinic acetylcholine receptors (nAChRs) exciting the nerve cells, causing trembling and shaking, paralysis [7], and even death [2, 8]. The neonicotinoid family includes acetamiprid, clothianidin, imidacloprid, nitenpyram, nithiazine, thiacloprid, and thiamethoxam [9]; in 2009, imidacloprid was the world’s top selling insecticide [3].…”

Section: Introductionmentioning

confidence: 99%

Quantification of DEET and neonicotinoid pesticide biomarkers in human urine by online solid-phase extraction high-performance liquid chromatography-tandem mass spectrometry

et al. 2018

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Neonicotinoid insecticides are widely used replacements for organophosphate and carbamate insecticides, but the extent of human exposure is largely unknown. On the other hand, based on urinary concentrations of DEET metabolites, human exposure to N,N-diethyl-m-toluamide (DEET) appears to be widespread. We developed a fast online solid-phase extraction high-performance liquid chromatography-isotope dilution tandem mass spectrometry (HPLC-MS/MS) method to measure in 200 μL of human urine the concentrations of six neonicotinoid biomarkers (acetamiprid, N-desmethyl-acetamiprid, clothianidin, imidacloprid, 5-hydroxy-imidacloprid, thiacloprid), and two DEET biomarkers (3-diethyl-carbamoyl benzoic acid, 3-ethyl-carbamoyl benzoic acid). Limits of detection ranged from 0.01 to 0.1 μg/L, depending on the biomarker. Accuracy ranged from 91 to 116% and precision ranged from 3.7 to 10 %RSD. The presented method can be used to increase our understanding of exposure to neonicotinoid insecticides and DEET, and to evaluate the potential health effects from such exposures.

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“…Imidacloprid is a neonicotinoid pesticide that has been on sale in the US since 1994 and is widely used in the control of pests and fleas in pets (Sheets, ). Once humans are exposed, imidacloprid products can cross the lining of the intestine and be transported to the whole body through circulation of the blood (Kasiotis & Machera, ). Nicotinoid metabolites derived from some neonicotinoids are more potent vertebrate postsynaptic nicotinic acetylcholinesterase receptors (nAChR) agonists than their parent molecules and are likely to be more toxic (Li, Ann, & Akk, ; Tomizawa & Casida, ).…”

Section: Chemical Agentsmentioning

confidence: 99%

The role of teratogens in neural crest development

Cerrizuela

Vega-Lopez

Aybar

2020

Birth Defects Research

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The neural crest (NC), discovered by Wilhelm His 150 years ago, gives rise to a multipotent migratory embryonic cell population that generates a remarkably diverse and important array of cell types during the development of the vertebrate embryo. These cells originate in the neural plate border (NPB), which is the ectoderm between the neural plate and the epidermis. They give rise to the neurons and glia of the peripheral nervous system, melanocytes, chondrocytes, smooth muscle cells, odontoblasts and neuroendocrine cells, among others. Neurocristopathies are a class of congenital diseases resulting from the abnormal induction, specification, migration, differentiation or death of NC cells (NCCs) during embryonic development and have an important medical and societal impact. In general, congenital defects affect an appreciable percentage of newborns worldwide. Some of these defects are caused by teratogens, which are agents that negatively impact the formation of tissues and organs during development. In this review, we will discuss the teratogens linked to the development of many birth defects, with a strong focus on those that specifically affect the development of the NC, thereby producing neurocristopathies.Although increasing attention is being paid to the effect of teratogens on embryonic development in general, there is a strong need to critically evaluate the specific role of these agents in NC development. Therefore, increased understanding of the role of these factors in NC development will contribute to the planning of strategies aimed at the prevention and treatment of human neurocristopathies, whose etiology was previously not considered.

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Neonicotinoids and their Metabolites in Human Biomonitoring: A Review

Cited by 11 publications

References 62 publications

Acute Poisoning with Neonicotinoid Insecticide

Acute Poisoning with Neonicotinoid Insecticide

Quantification of DEET and neonicotinoid pesticide biomarkers in human urine by online solid-phase extraction high-performance liquid chromatography-tandem mass spectrometry

The role of teratogens in neural crest development

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