2011
DOI: 10.3174/ajnr.a2723
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Neonatal Tract-Based Spatial Statistics Findings and Outcome in Preterm Infants

Abstract: BACKGROUND AND PURPOSE: WM injury is associated with different disabilities that children born prematurely may experience during their lives. The aim of this study was to use TBSS to test the hypothesis that WM microstructure at TEA in preterm infants is correlated with cognitive and motor outcome at 2-year corrected age.

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Cited by 150 publications
(160 citation statements)
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“…A positive association between motor function and FA in VLBW populations has been found in infancy 251 , childhood 54 , adolescence 224 and young adulthood 233 . There are also studies that do not indicate any association between motor function and FA 46,138 .…”
Section: Associations Between White Matter Microstructure and Motor Fmentioning
confidence: 99%
See 1 more Smart Citation
“…A positive association between motor function and FA in VLBW populations has been found in infancy 251 , childhood 54 , adolescence 224 and young adulthood 233 . There are also studies that do not indicate any association between motor function and FA 46,138 .…”
Section: Associations Between White Matter Microstructure and Motor Fmentioning
confidence: 99%
“…The majority of such studies have examined the association between FA across the whole brain and cognitive functions 7,64,173,212 , while the minority of the studies have investigated the association between FA and motor function. In very preterm infants, a positive correlation has been reported between FA throughout the white matter and fine motor scores 251 . Another study found no relationship between FA values and a motor sub-scale in very preterm individuals without major motor problems or focal lesions at two years 46 .…”
Section: White Matter Microstructurementioning
confidence: 99%
“…The effect size of SNPs in the FADS2 locus is large, with approximately one-third of the variability of PUFA and LC-PUFA levels in human tissues attributable to genotype. 55,59 These effects were detected through the use of TBSS, which provides a novel and powerful method for detecting group-wise differences in white matter microstructure predictive of later neurodevelopmental outcome, 20,21 overcoming the diagnostic imprecision of neurodevelopmental assessment in early childhood and allowing significantly smaller sample sizes. Modeling and neonatal clinical studies have shown that clinically significant changes in FA can be detected in groups as small as 10 patients per group.…”
Section: Figurementioning
confidence: 99%
“…17,18 These methods allow powerful unbiased group-wise studies of genetic risk. [19][20][21] Based on studies of the imaging and clinical phenotype we hypothesized that the development of preterm cerebral injury could be related to genes involved in white matter development or human cognition and behavior. We used TBSS and deformation-based morphometry to examine the risks conferred by carriage of particular alleles at single nucleotide polymorphisms (SNPs) 22 located within a small number of candidate genes (Supplemental Table 1).…”
mentioning
confidence: 99%
“…14,15 Previous TBSS studies examining outcome measures at 2 years (corrected age) in children born preterm reported that increased FA levels were associated with better outcome. 14,15 For example, Van Kooij et al 16 reported that the increase in FA in the corpus callosum, fornix, external and internal capsules, superior longitudinal fasciculus, inferior longitudinal and fronto-occipital fasciculi, cingulum, and uncinate fasciculus in their preterm population was positively associated with improved fine motor scores, explained by a decrease in RD. Conversely, the findings of lower FA and increased RD values associated with poorer fine motor scores were interpreted to reflect disruptions in premyelination processes.…”
mentioning
confidence: 99%