Common Genetic Variants and Risk of Brain Injury After Preterm Birth

Boardman, James P.; Walley, Andrew J.; Ball, Gareth; Takousis, Petros; Krishnan, Michelle L.; Hughes-Carre, Laurelle; Aljabar, Paul; Serag, Ahmed; King, Caroline C.; Merchant, Nazakat; Srinivasan, Latha; Froguel, Philippe; Hajnal, Joseph V.; Rueckert, Daniel; Counsell, Serena J.; Edwards, A. David

doi:10.1542/peds.2013-3011

Cited by 48 publications

(39 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Important first steps have recently been taken, cross-correlating common genetic variation analysis with DWI findings in preterm neonates (Boardman et al, 2014;Krishnan et al, 2016). These studies illustrated genes mostly involved in lipid pathways to be related to the degree of maturation of distributed white matter tracts at term equivalent age.…”

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

The emergence of functional architecture during early brain development

2017

View full text Add to dashboard Cite

Early human brain development constitutes a sequence of intricate processes resulting in the ontogeny of functionally operative neural circuits. Developmental trajectories of early brain network formation are genetically programmed and can be modified by epigenetic and environmental influences. Such alterations may exert profound effects on neurodevelopment, potentially persisting throughout the lifespan. This review focuses on the critical period of fetal and early postnatal brain development. Here we collate findings from neuroimaging studies, with a particular focus on functional MRI research that interrogated early brain network development in both health and high-risk or disease states. First, we will provide an overview of the developmental processes that take place from the embryonic period through early infancy in order to contextualize brain network formation. Second, functional brain network development in the typically developing brain will be discussed. Third, we will touch on prenatal and perinatal risk factors that may interfere with the trajectories of functional brain wiring, including prenatal substance exposure, maternal mental illness and preterm

show abstract

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

The emergence of functional architecture during early brain development

2017

View full text Add to dashboard Cite

show abstract

“…These results suggest that genetic variants may influence the effects of preterm birth on white matter development (Boardman et al, 2014). Severe fetal hypoxia was associated with smaller volume of the hippocampus in schizophrenia patients, and this pathology correlated with rs13242038 polymorphism in the GRM3 gene, (Haukvik et al, 2010).…”

Section: Gene-environment Interplaymentioning

confidence: 90%

Animal models of gene–environment interaction in schizophrenia: A dimensional perspective

Ayhan

McFarland

Pletnikov

2016

Progress in Neurobiology

View full text Add to dashboard Cite

Schizophrenia has long been considered as a disorder with multifactorial origins. Recent discoveries have advanced our understanding of the genetic architecture of the disease. However, even with the increase of identified risk variants, heritability estimates suggest an important contribution of non-genetic factors. Various environmental risk factors have been proposed to play a role in the etiopathogenesis of schizophrenia. These include season of birth, maternal infections, obstetric complications, adverse events at early childhood, and drug abuse. Despite the progress in identification of genetic and environmental risk factors, we still have a limited understanding of the mechanisms whereby gene-environment interactions (GxE) operate in schizophrenia and psychoses at large. In this review we provide a critical analysis of current animal models of GxE relevant to psychotic disorders and propose that dimensional perspective will advance our understanding of the complex mechanisms of these disorders.

show abstract

“…Researchers are now also attempting to integrate genetics and function with human connectivity, in central homeostatic network 23 and in utero pathways. This integrative approach, for example, has been initiated with candidate genes and brain injury associated with preterm birth 81,82 Currently, information regarding physiologic vulnerability and the cascade of physiologic events leading to SIDS is limited. Advances in bedside recording in NICUs allow for the generation of vast amounts of longitudinal data in infants, including cardiac, respiratory, and neural parameters.…”

Section: Promising Approaches For Discovery Of Underlying Vulnerabilimentioning

confidence: 99%

Sudden Unexpected Death in Fetal Life Through Early Childhood

2016

View full text Add to dashboard Cite

In March 2015, the Eunice Kennedy Shriver National Institute of Child Health and Human Development held a workshop entitled “Sudden Unexpected Death in Fetal Life Through Early Childhood: New Opportunities.” Its objective was to advance efforts to understand and ultimately prevent sudden deaths in early life, by considering their pathogenesis as a potential continuum with some commonalities in biological origins or pathways. A second objective of this meeting was to highlight current issues surrounding the classification of sudden infant death syndrome (SIDS), and the implications of variations in the use of the term “SIDS” in forensic practice, and pediatric care and research. The proceedings reflected the most current knowledge and understanding of the origins and biology of vulnerability to sudden unexpected death, and its environmental triggers. Participants were encouraged to consider the application of new technologies and “omics” approaches to accelerate research. The major advances in delineating the intrinsic vulnerabilities to sudden death in early life have come from epidemiologic, neural, cardiac, metabolic, genetic, and physiologic research, with some commonalities among cases of unexplained stillbirth, SIDS, and sudden unexplained death in childhood observed. It was emphasized that investigations of sudden unexpected death are inconsistent, varying by jurisdiction, as are the education, certification practices, and experience of death certifiers. In addition, there is no practical consensus on the use of “SIDS” as a determination in cause of death. Major clinical, forensic, and scientific areas are identified for future research.

show abstract

Common Genetic Variants and Risk of Brain Injury After Preterm Birth

Cited by 48 publications

References 72 publications

The emergence of functional architecture during early brain development

The emergence of functional architecture during early brain development

Animal models of gene–environment interaction in schizophrenia: A dimensional perspective

Sudden Unexpected Death in Fetal Life Through Early Childhood

Contact Info

Product

Resources

About