Tract-Based Spatial Statistics in Preterm-Born Neonates Predicts Cognitive and Motor Outcomes at 18 Months

Duerden, Emma G.; Foong, Justin; Chau, Vann; Branson, Helen M.; Poskitt, Kenneth J.; Grunau, Ruth E.; Synnes, Anne; Zwicker, Jill G.; Miller, Steven P.

doi:10.3174/ajnr.a4312

Cited by 63 publications

(62 citation statements)

References 28 publications

(33 reference statements)

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“…The TBSS FA data were projected onto a mean FA tract skeleton, which was used to apply the voxelwise cross-subject statistics 23. We used five age-based templates and were able to compare neonate groups with a standardised analysis and a calculated voxel significance threshold of p<0.05 adjusted for PMA at scan 12. White matter abnormalities detected with TBSS at term-equivalent age have been shown to predict neurodevelopmental outcomes in preterm neonates 12 24…”

Section: Methodsmentioning

confidence: 99%

Severe retinopathy of prematurity predicts delayed white matter maturation and poorer neurodevelopment

Glass

Chau

Gardiner

et al. 2017

Arch Dis Child Fetal Neonatal Ed

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Section: Methodsmentioning

confidence: 99%

Severe retinopathy of prematurity predicts delayed white matter maturation and poorer neurodevelopment

Glass

Chau

Gardiner

et al. 2017

Arch Dis Child Fetal Neonatal Ed

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“…An alternative to the ROI approach is to analyse DTI data for the whole brain volume, which can detect more subtle brain injury (23). Previous studies that applied whole brain statistical analysis for DTI parameters in preterm infants demonstrated a reduction in DTI measures, thought to reflect alternations in brain microstructure (24, 25).…”

Section: Introductionmentioning

confidence: 99%

Diffusion Tensor Imaging Colour Mapping Threshold for Identification of Ventilation-Induced Brain Injury after Intrauterine Inflammation in Preterm Lambs

et al. 2017

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PurposeThe aim of this study is to examine whether advanced magnetic resonance imaging (MRI) techniques can detect early brain injury caused by intrauterine inflammation and inappropriate initial respiratory support in preterm lambs.HypothesisNeuropathology caused by intrauterine inflammation is exacerbated by mechanical ventilation at birth and is detectable with advanced MRI techniques.MethodsPregnant ewes received intra-amniotic lipopolysaccharide (LPS) 7 days prior to delivery at ~125 days of gestation (85% of gestation), whereupon lambs were delivered and randomised to receive an injurious (LPS + INJ, n = 6) or protective (LPS + PROT, n = 6) ventilation strategy. MRI of the brain was conducted 90 min after preterm delivery, using structural, diffusion tensor imaging (DTI), and magnetic resonance spectroscopy (MRS) techniques. A colour map threshold technique was utilised to compare distributions of low diffusivity voxels in the brains of LPS-exposed lambs with those not exposed to LPS (PROT, n = 7 PROT and INJ, n = 10).ResultsNo overt cerebral injury was identified on structural MRI images of any lamb. However, on DTI, axial diffusivity, radial diffusivity, and mean diffusivity values were lower and significantly more heterogeneous in specific brain regions of lambs in the LPS + INJ group compared to the LPS + PROT group. Colour mapping revealed lower diffusivity in the thalamus, periventricular white matter, internal capsule, and frontal white matter in the LPS + INJ group compared to LPS + PROT group. The MRS peak area ratios of lactate, relative to those for the metabolites creatine, choline, and N-acetylaspartate, were not different between LPS-exposed groups. Lambs exposed to LPS had lower diffusivity within the white matter regions assessed than non-LPS-treated control lambs.ConclusionDTI colour map threshold techniques detected early brain injury in preterm lambs exposed to intrauterine inflammation and detected differences between injurious and protective ventilation strategies. DTI mapping approaches are potentially useful for early detection of subtle brain injury in premature infants.

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“…Nevertheless, few studies have been conducted to evaluate the correlations between WM connectivity as revealed by DTI and motor neurodevelopment of extremely low birth weight (ELBW; <1000 g) infants with WM abnormalities [7, 8]. Therefore, this study aimed to determine the diffusion tensor characteristics of WM regions associated with motor outcome among preterm infants with or without WM abnormalities and/or cerebral palsy (CP).…”

Section: Introductionmentioning

confidence: 99%

Neonatal diffusion tensor brain imaging predicts later motor outcome in preterm neonates with white matter abnormalities

et al. 2016

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BackgroundWhite matter (WM) abnormalities associated with prematurity are one of the most important causes of neurological disability that involves spastic motor deficits in preterm newborns. This study aimed to evaluate regional microstructural changes in diffusion tensor imaging (DTI) associated with WM abnormalities.MethodsWe prospectively studied extremely low birth weight (ELBW; <1000 g) preterm infants who were admitted to the Neonatal Intensive Care Unit of Hanyang University Hospital between February 2011 and February 2014. WM abnormalities were assessed with conventional magnetic resonance (MR) imaging and DTI near term-equivalent age before discharge. Region-of-interests (ROIs) measurements were performed to examine the regional distribution of fractional anisotropy (FA) values.ResultsThirty-two out of 72 ELBW infants underwent conventional MR imaging and DTI at term-equivalent age. Ten of these infants developed WM abnormalities associated with prematurity. Five of ten of those with WM abnormalities developed cerebral palsy (CP). DTI in the WM abnormalities with CP showed a significant reduction of mean FA in the genu of the corpus callosum (p = 0.022), the ipsilateral posterior limb of the internal capsule (p = 0.019), and the ipsilateral centrum semiovale (p = 0.012) compared to normal WM and WM abnormalities without CP. In infants having WM abnormalities with CP, early FA values in neonatal DTI revealed abnormalities of the WM regions prior to the manifestation of hemiparesis.ConclusionsDTI performed at term equivalent age shows different FA values in WM regions among infants with or without WM abnormalities associated with prematurity and/or CP. Low FA values of ROIs in DTI are related with later development of spastic CP in preterm infants with WM abnormalities.Electronic supplementary materialThe online version of this article (doi:10.1186/s13052-016-0309-9) contains supplementary material, which is available to authorized users.

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Tract-Based Spatial Statistics in Preterm-Born Neonates Predicts Cognitive and Motor Outcomes at 18 Months

Cited by 63 publications

References 28 publications

Severe retinopathy of prematurity predicts delayed white matter maturation and poorer neurodevelopment

Severe retinopathy of prematurity predicts delayed white matter maturation and poorer neurodevelopment

Diffusion Tensor Imaging Colour Mapping Threshold for Identification of Ventilation-Induced Brain Injury after Intrauterine Inflammation in Preterm Lambs

Neonatal diffusion tensor brain imaging predicts later motor outcome in preterm neonates with white matter abnormalities

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