Neonatal neutropenia due to maternal autoantibodies against neutrophils.

Neonatal neutropenia and bacterial sepsis associated with placental transfer of maternal neutrophil‐specific autoantibodies

“…It is not unusual to identify chronic AIN in a routine blood count 19 . From experience with the cases described here and others reported previously 24‐26 it seems prudent to perform careful clinical and hematologic assessments on infants born to any woman in whom this condition is a diagnostic possibility.…”

“…‐23 The fact that mothers with AIN may give birth to infants with transient neonatal neutropenia was first observed by Stefanini and colleagues in 1958 24 . They described two cases, and since then, seven additional cases have been described in the literature 25‐27 . In these infants, neutrophil counts normalized between 1 and 4 months of age, but two developed bacterial infections requiring antibiotic therapy while they were neutropenic 24,26 …”

Platelets and Neutrophils from Healthy Term Neonates Exhibit Increased Levels of Immunoglobulins

“…Autoimmune neonatal thrombocytopenia may be associated with maternal autoimmune disorders including systemic lupus erythematosus, immune thrombocytopenic purpura, hypothyroidism, lymphoproliferative disorders, or other autoimmune diseases in which IgG class autoantibodies cross the placenta and cause destruction of the infant's platelets (21)(22)(23)(24). Neonatal neutropenia may also be associated with the passage of maternal autoantibodies across the placenta (4,25). The diagnosis of autoimmune neutropenia, also known as transitory neonatal neutropenia, is dependent upon the demonstration of maternal autoantibodies directed against antigens common to both mother and fetus resulting in destruction of neutrophils (21)(22)(23)(24)(25)(26).…”

“…Neonatal neutropenia may also be associated with the passage of maternal autoantibodies across the placenta (4,25). The diagnosis of autoimmune neutropenia, also known as transitory neonatal neutropenia, is dependent upon the demonstration of maternal autoantibodies directed against antigens common to both mother and fetus resulting in destruction of neutrophils (21)(22)(23)(24)(25)(26).…”

Diagnosis and management of primary autoimmune neutropenia in children: insights for clinicians

“…• Neonatal alloimmune neutropenia secondary to maternal autoimmune neutropenia: there are few reports in literature [van Leeuwen et al 1983;Kameoka et al 2001;Davoren et al 2004;Fung et al 2005]. The differential diagnosis is simple if the type of neutropenia in the mother has been assessed correctly.…”