2018
DOI: 10.1016/j.cub.2017.11.060
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Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the Brown Planthopper

Abstract: SummaryGene duplication is a major source of genetic variation that has been shown to underpin the evolution of a wide range of adaptive traits [1, 2]. For example, duplication or amplification of genes encoding detoxification enzymes has been shown to play an important role in the evolution of insecticide resistance [3, 4, 5]. In this context, gene duplication performs an adaptive function as a result of its effects on gene dosage and not as a source of functional novelty [3, 6, 7, 8]. Here, we show that dupl… Show more

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Cited by 136 publications
(199 citation statements)
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“…This result also suggests that overexpression of detoxifying enzymes, such as P450s, may be involved in imidacloprid resistance in the VT‐ and PH‐Res strains to the same extent as gene dominance. Bass et al showed that overexpression of a cytochrome‐P450‐monooxygenase, CYP6ER1 , was associated with imidacloprid resistance in three laboratory strains collected in Thailand and China by Gorman et al Zimmer et al showed that two different sequence variants of CYP6ER1 were associated with its overexpression in imidacloprid‐resistant strains of N. lugens collected from India, Thailand, Vietnam, Indonesia and Japan. The VT‐Res strain from our study might have developed imidacloprid resistance by the same variants in CYP6ER1 because our strain originated from southern Vietnam in 2009, a similar place and time as the populations characterized in Zimmer et al Furthermore, not only VT‐Res, but also the PH‐Res strain originating from the northern Philippines might have the same variants in CYP6ER1 because overexpression of CYP6ER1 associated with imidacloprid resistance has spread widely throughout Asia, as reported by Zimmer et al …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…This result also suggests that overexpression of detoxifying enzymes, such as P450s, may be involved in imidacloprid resistance in the VT‐ and PH‐Res strains to the same extent as gene dominance. Bass et al showed that overexpression of a cytochrome‐P450‐monooxygenase, CYP6ER1 , was associated with imidacloprid resistance in three laboratory strains collected in Thailand and China by Gorman et al Zimmer et al showed that two different sequence variants of CYP6ER1 were associated with its overexpression in imidacloprid‐resistant strains of N. lugens collected from India, Thailand, Vietnam, Indonesia and Japan. The VT‐Res strain from our study might have developed imidacloprid resistance by the same variants in CYP6ER1 because our strain originated from southern Vietnam in 2009, a similar place and time as the populations characterized in Zimmer et al Furthermore, not only VT‐Res, but also the PH‐Res strain originating from the northern Philippines might have the same variants in CYP6ER1 because overexpression of CYP6ER1 associated with imidacloprid resistance has spread widely throughout Asia, as reported by Zimmer et al …”
Section: Discussionmentioning
confidence: 99%
“…These mechanisms may lead to development of insecticide resistance either individually or in combination. High expression of cytochrome P450 genes has been reported to contribute to imidacloprid resistance in N. lunges field populations . A mutation in a target site of action has also been reported to cause insecticide resistance but only in a selection reared in a laboratory, not in field populations.…”
Section: Introductionmentioning
confidence: 99%
“…pipiens [23] and Aedes albopictus [24], and to several insecticides in the peach-potato aphid Myzus persicae [25,26]. In brown planthoppers, neofunctionalisation of a duplicated copy of Cyp6er1 has even created a novel gene variant providing resistance to the neonicotinoid imidacloprid [27]. In An.…”
Section: Introductionmentioning
confidence: 99%
“…Likewise, Voudouris et al (2018) reported that the expression of CcCYP6A51 presented a high variability in field populations. At present, several studies have associated CNV of P450 genes with insecticide resistance in a number of insect species (Wondji et al, 2009;Bariami et al, 2012;Zimmer et al, 2018), which can then potentially be used as DNA diagnostic markers. However, we did not find variations in the number of copies for any of the P450 genes analyzed between the resistant W-1Kλ and the susceptible C strains.…”
Section: Discussionmentioning
confidence: 99%
“…DNA diagnostic markers are more simple and reliable methods than those based on transcripts (Devine and Denholm, 2009). A source of DNA polymorphism that has not been checked is the possibility of copy number variation (CNV) of genes involved in resistance (Feyereisen et al, 2015;Weetman et al, 2018), since P450 gene amplification has been associated with insecticide resistance in a number of species (Wondji et al, 2009;Bariami et al, 2012;Zimmer et al, 2018). In addition, the availability of medfly genome sequence (Papanicolaou et al, 2016) makes possible genome-wide studies scanning the genome or transcriptome to identify polymorphisms linked to insecticide resistance (Devine and Denholm, 2009).…”
Section: Rationale For the Studymentioning
confidence: 99%