Nelson Bay virus

Gard, G. P.; Marshall, I. D.

doi:10.1007/bf01249346

Cited by 37 publications

(15 citation statements)

References 13 publications

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“…For this experiment we utilized the bat orthoreovirus Nelson Bay virus (NBV) [22]. NBV is also known as Pteropine orthoreovirus NB (PRV1NB) [23].…”

Section: Resultsmentioning

confidence: 99%

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Proteomics informed by transcriptomics reveals Hendra virus sensitizes bat cells to TRAIL mediated apoptosis

Wynne¹,

Shiell²,

Marsh³

et al. 2014

Genome Biol

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Background: Bats are a major reservoir of emerging infectious viruses. Many of these viruses are highly pathogenic to humans however bats remain asymptomatic. The mechanism by which bats control viral replication is unknown. Here we utilize an integrated approach of proteomics informed by transcriptomics to compare the response of immortalized bat and human cells following infection with the highly pathogenic bat-borne Hendra virus (HeV).

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“…For this experiment we utilized the bat orthoreovirus Nelson Bay virus (NBV) [22]. NBV is also known as Pteropine orthoreovirus NB (PRV1NB) [23].…”

Section: Resultsmentioning

confidence: 99%

“…For both assays, approximately, 30,000 cells/well were seeded into white 96-well plates. Cells were infected with HeV or NBV [22] for 24, 48 and 72 h at an MOI of approximately 5. Both assays were performed exactly as per the manufacturer’s instructions, in triplicate.…”

Section: Methodsmentioning

confidence: 99%

Proteomics informed by transcriptomics reveals Hendra virus sensitizes bat cells to TRAIL mediated apoptosis

Wynne¹,

Shiell²,

Marsh³

et al. 2014

Genome Biol

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“…PRV1NB, (alternatively known as Nelson Bay virus) was first isolated in 1968 from Australian bats (Pteropus policephalus) and then almost 40 years later PRV3M (alternatively known as Melaka virus) was isolated from humans with acute respiratory illness. [1][2][3] Subsequently, evidence of different PRV infection has been observed in other Southeast Asian countries in both humans and bats, with a seroprevalence of 4.4%-13% in specific populations. [4][5][6][7] Numerous reports of PRV exposure across the region suggest that continuous spillover events are occurring.…”

Section: Introductionmentioning

confidence: 96%

“…Pteropine orthoreovirus (PRV) is a group of fusogenic viruses in the genus Orthoreovirus with a ten‐segment genome. PRV1NB, (alternatively known as Nelson Bay virus) was first isolated in 1968 from Australian bats ( Pteropus policephalus ) and then almost 40 years later PRV3M (alternatively known as Melaka virus) was isolated from humans with acute respiratory illness . Subsequently, evidence of different PRV infection has been observed in other Southeast Asian countries in both humans and bats, with a seroprevalence of 4.4%‐13% in specific populations .…”

Section: Introductionmentioning

confidence: 99%

Serological evidence of human infection by bat orthoreovirus in Singapore

Uehara

Tan

Mani

et al. 2018

Journal of Medical Virology

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To determine whether Pteropine orthoreovirus (PRV) exposure has occurred in Singapore, we tested 856 individuals from an existing serum panel collected from 2005‐2013. After an initial screen with luciferase immunoprecipitation system and secondary confirmation with virus neutralization test, we identified at least seven individuals with specific antibodies against PRV in both assays. Our findings confirm that PRV spillover into human populations is relatively common in this region of the world.

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“…The first reovirus of bat origin, NBV, was isolated in 1968 from the heart blood of a flying fox (Pteropus poliocephalus) in New South Wales, Australia (20). NBV was the first mammalian orthoreovirus to display the fusogenic properties characteristic of avian orthoreoviruses (21).…”

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confidence: 99%

A previously unknown reovirus of bat origin is associated with an acute respiratory disease in humans

Chua

Crameri

Hyatt

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

201

259

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Respiratory infections constitute the most widespread human infectious disease, and a substantial proportion of them are caused by unknown etiological agents. Reoviruses (respiratory enteric orphan viruses) were first isolated from humans in the early 1950s and so named because they were not associated with any known disease. Here, we report a previously unknown reovirus (named ''Melaka virus'') isolated from a 39-year-old male patient in Melaka, Malaysia, who was suffering from high fever and acute respiratory disease at the time of virus isolation. Two of his family members developed similar symptoms Ϸ1 week later and had serological evidence of infection with the same virus. Epidemiological tracing revealed that the family was exposed to a bat in the house Ϸ1 week before the onset of the father's clinical symptoms. Genome sequence analysis indicated a close genetic relationship between Melaka virus and Pulau virus, a reovirus isolated in 1999 from fruit bats in Tioman Island, Malaysia. Screening of sera collected from human volunteers on the island revealed that 14 of 109 (13%) were positive for both Pulau and Melaka viruses. This is the first report of an orthoreovirus in association with acute human respiratory diseases. Melaka virus is serologically not related to the different types of mammalian reoviruses that were known to infect humans asymptomatically. These data indicate that batborne reoviruses can be transmitted to and cause clinical diseases in humans.respiratory infection ͉ zoonosis ͉ human-to-human transmission ͉ orthoreovirus ͉ Pulau virus

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Nelson Bay virus

Abstract: Biological and serological procedures have established that Nelson Bay virus (NB847), which was recovered from the blood of a fruit bat or "flying fox" (Pteropus poliocephalus), is a member of the reovirus group and that it differs from previously described reoviruses.

Cited by 37 publications

References 13 publications

Proteomics informed by transcriptomics reveals Hendra virus sensitizes bat cells to TRAIL mediated apoptosis

Proteomics informed by transcriptomics reveals Hendra virus sensitizes bat cells to TRAIL mediated apoptosis

Serological evidence of human infection by bat orthoreovirus in Singapore

A previously unknown reovirus of bat origin is associated with an acute respiratory disease in humans

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