Negative L.E.-CELL Phenomenon in True Systemic Lupus Erythematosus

Formijne, P.; Soeren, F. Van

doi:10.1016/s0140-6736(58)92357-2

Cited by 15 publications

(2 citation statements)

References 2 publications

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“…A negative LE cell phenomenon in SLE has been reported by Formijne and Van Soeren [5]. Anticomplementary substances have been advanced as a cause, the complement playing a role in the nucleophagocytosis in the LE cell phenomenon.…”

Section: Discussionmentioning

confidence: 87%

Third Component of Complement (C3) and Fourth Component of Complement (C4) in Discoid and Systemic Lupus erythematosus

Risum¹

1973

Dermatology

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In 54 patients with lupus erythematosus – 6 with systemic, 19 with disseminated discoid, and 29 with localized discoid lupus erythematosus determination of the 3rd and 4th components of complement (C3 and C4) was performed in a prospective study. In relation to 42 healthy persons, the mean value of C3 proved significantly reduced in systemic lupus erythematosus, and the mean value of C4 was significantly reduced in systemic as well as in disseminated discoid lupus erythematosus. When C3 and C4 were related to disease activity, a depression of complement was found parallel to an increase in disease activity in all three forms of lupus erythematosus. Compared with other serological tests, C3 and C4 afforded the best serological evaluation of the disease activity. Alterations in the clinical condition in 8 of the patients with discoid lupus erythematosus were preceded by changes in C4. A single determination of C4 was diagnostic in 8% of the patients with discoid lupus erythematosus.

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Section: Discussionmentioning

confidence: 87%

Third Component of Complement (C3) and Fourth Component of Complement (C4) in Discoid and Systemic Lupus erythematosus

Risum¹

1973

Dermatology

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“…cell formation (Formijne and van Soeren, 1958), we discovered the lability of the phagocytosis, and observed the stability and constancy of the first phase of the L.E. cell phenomenon, the loose body formation, remained in many changing circumstances.…”

Section: Discussionmentioning

confidence: 99%

Simple Determination of the L.E. Factor: Loose Body Test and Nucleus Agglutination Inhibition Test

Soeren¹

1961

Annals of the Rheumatic Diseases

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Role of igg and igm antinuclear antibodies in formation of lupus erythematosus cells and extracellular material

Blondin

McDuffie

1970

Arthritis & Rheumatism

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IgM and IgG antinuclear antibodies (ANA) have been compared for their ability to produce hematoxylin bodies (ECM) and LE cells. At equivalent ANA concentrations (determined by immunofluorescent staining of rabbit liver nuclei), IgM formed ECM indistinguishable from those produced by IgG but, even at very high concentrations, failed to produce LE cells. Inability of IgM ANA to produce LE cells is probably due to lack of complement fixation rather than to a difference in antinuclear specificity.

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Negative L.E.-CELL Phenomenon in True Systemic Lupus Erythematosus

Cited by 15 publications

References 2 publications

Third Component of Complement (C3) and Fourth Component of Complement (C4) in Discoid and Systemic Lupus erythematosus

Third Component of Complement (C3) and Fourth Component of Complement (C4) in Discoid and Systemic Lupus erythematosus

Simple Determination of the L.E. Factor: Loose Body Test and Nucleus Agglutination Inhibition Test

Role of igg and igm antinuclear antibodies in formation of lupus erythematosus cells and extracellular material

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