“…DLE is not usually associated with any other disease process, although O'Loughlin et al (1978) pointed out that the patients with generalized DLE are more likely to have arthralgias, Raynaud's phenomenon, and fever than are patients with lesions localized to the head and neck. Lupus erythematosus-like skin lesions have been noted in several patients with familial complement deficiency (Osterland, Espinoza & Parker, 1975;Douglass et al, 1976), and significant reduction in C4 has been demonstrated in patients with generalized DLE (Risum, 1973)-OUT patient i, in addition to having a drug-induced Coombs-positive haemolytic anaemia, had total haemolytic complement that was too low to measure, with normal C3 and greatly reduced C4. He had a pronounced and persistent elevation of an IgG / monoclonal protein (more than 3 g/dl), greater than 10",, abnormal plasma cells in the bone marrow, but without progression to anaemia, lytic bone lesions, hypercalcaemia, or renal failure, fulfilling the criteria for 'smouldering' multiple myeloma (Kyle & Grcipp, 1980).…”