Neem gum based pH responsive hydrogel matrix: A new pharmaceutical excipient for the sustained release of anticancer drug

Mankotia, Priyanka; Choudhary, Sonal; Sharma, Kashma; Kumar, Vijay; Bhatia, Jaspreet Kaur; Parmar, Ankush; Sharma, Shweta; Sharma, Vishal

doi:10.1016/j.ijbiomac.2019.10.015

Cited by 20 publications

(7 citation statements)

References 54 publications

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“…In addition to these data, it was important to determine the diffusional exponent n, which is a parameter that indicates the mechanism of drug release and varies depending on the geometry of the release device. Fickian diffusion is confirmed for n < 0.45; when 0.45 < n < 0.89, the drug transport is anomalous (non-Fickian)—in other words, the diffusion and relaxation rates are similar and the physical phenomena are diffusion and erosion of the matrix; if n > 0.89, then the key mechanism of drug release is Case II transport, thus, the drug release is determined by polymer relaxation [ 26 , 44 ]. The values obtained for the exponent n suggested anomalous (non-Fickian) transport, which indicated that the drug is released from the hydrogels by diffusion associated with the materials erosion.…”

Section: Resultsmentioning

confidence: 99%

Design and Preparation of New Multifunctional Hydrogels Based on Chitosan/Acrylic Polymers for Drug Delivery and Wound Dressing Applications

et al. 2020

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The dynamic evolution of materials with medical applications, particularly for drug delivery and wound dressing applications, gives impetus to design new proposed materials, among which, hydrogels represent a promising, powerful tool. In this context, multifunctional hydrogels have been obtained from chemically modified chitosan and acrylic polymers as cross-linkers, followed by subsequent conjugation with arginine. The hydrogels were finely tuned considering the variation of the synthetic monomer and the preparation conditions. The advantage of using both natural and synthetic polymers allowed porous networks with superabsorbent behavior, associated with a non-Fickian swelling mechanism. The in vitro release profiles for ibuprofen and the corresponding kinetics were studied, and the results revealed a swelling-controlled release. The biodegradability studies in the presence of lysozyme, along with the hemostatic evaluation and the induced fibroblast and stem cell proliferation, have shown that the prepared hydrogels exhibit characteristics that make them suitable for local drug delivery and wound dressing.

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Section: Resultsmentioning

confidence: 99%

Design and Preparation of New Multifunctional Hydrogels Based on Chitosan/Acrylic Polymers for Drug Delivery and Wound Dressing Applications

et al. 2020

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“…Overall, a commonly used technique is the incorporation of nanoparticles into various hydrogel systems [215][216][217][218]. Mucoadhesive properties of nanoparticles are achieved by using various biopolymers such as chitosan, sodium alginate, guar gum, hydroxyethyl cellulose, methylcellulose, etc.…”

Section: Nanotechnology-based Systems To Improve Buccal Drug Deliverymentioning

confidence: 99%

Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D

Dubashynskaya,

Petrova,

Skorik

2024

IJMS

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Oromucosal drug delivery, both local and transmucosal (buccal), is an effective alternative to traditional oral and parenteral dosage forms because it increases drug bioavailability and reduces systemic drug toxicity. The oral mucosa has a good blood supply, which ensures that drug molecules enter the systemic circulation directly, avoiding drug metabolism during the first passage through the liver. At the same time, the mucosa has a number of barriers, including mucus, epithelium, enzymes, and immunocompetent cells, that are designed to prevent the entry of foreign substances into the body, which also complicates the absorption of drugs. The development of oromucosal drug delivery systems based on mucoadhesive biopolymers and their derivatives (especially thiolated and catecholated derivatives) is a promising strategy for the pharmaceutical development of safe and effective dosage forms. Solid, semi-solid and liquid pharmaceutical formulations based on biopolymers have several advantageous properties, such as prolonged residence time on the mucosa due to high mucoadhesion, unidirectional and modified drug release capabilities, and enhanced drug permeability. Biopolymers are non-toxic, biocompatible, biodegradable and may possess intrinsic bioactivity. A rational approach to the design of oromucosal delivery systems requires an understanding of both the anatomy/physiology of the oral mucosa and the physicochemical and biopharmaceutical properties of the drug molecule/biopolymer, as presented in this review. This review summarizes the advances in the pharmaceutical development of mucoadhesive oromucosal dosage forms (e.g., patches, buccal tablets, and hydrogel systems), including nanotechnology-based biopolymer nanoparticle delivery systems (e.g., solid lipid particles, liposomes, biopolymer polyelectrolyte particles, hybrid nanoparticles, etc.).

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“…Neem gum has also been used to make hydrogel for drug delivery of anticancer drug methotrexate (MTX) under different pH conditions. Neem gum-based hydrogel was determined to be a good carrier for MTX as the gel protects the drug from hostile environmental conditions, releases the drug in optimal quantities, therefore reducing the toxic side effects ( 107 ). Carbon dots, derived from Neem gum have biolinkers attached on their surface and stable green fluorescence which make them suitable for drug delivery system and/or biosensors ( 108 ).…”

Section: Active Components Of Neem and Dose Formsmentioning

confidence: 99%

Exploring the therapeutic potential of Neem (Azadirachta Indica) for the treatment of prostate cancer: a literature review

et al. 2022

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Background and Objective: Multiple studies have demonstrated the medical potency of plant extracts and specific phytochemicals as therapeutics for prostate cancer (PCa) patients. Of note, the Neem plant known for its role as an antibiotic and anti-inflammatory is underexplored with an untapped potential for further development. This review focuses on extracts and phytochemicals derived from the Neem tree (Latin name; Azadirachta indica), commonly used throughout Southeast Asia for the prevention and treatment of a wide array of diseases including cancer. To date, there are more than 130 biologically active compounds that have been isolated from the Neem tree including azadirachtin, nimbolinin, nimbin, nimbidin, nimbidol, which have demonstrated a wide range of biological activities including anti-microbial, anti-fertility, antiinflammatory, anti-arthritic, hepatoprotective, anti-diabetic, anti-ulcer, and anti-cancer effects. Very few scientific reports focus on the benefits of Neem in PCa, even though this herb has been used to prevent the disease and its progression for years in complementary and alternative medicine.Methods: We used the search engines like PubMed, InCommon and Google using the key words: "Neem", "Cancer", "Prostate Cancer" and related words to find the information and data within the time frame from 1980-2022 for our article study.

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Neem gum based pH responsive hydrogel matrix: A new pharmaceutical excipient for the sustained release of anticancer drug

Cited by 20 publications

References 54 publications

Design and Preparation of New Multifunctional Hydrogels Based on Chitosan/Acrylic Polymers for Drug Delivery and Wound Dressing Applications

Design and Preparation of New Multifunctional Hydrogels Based on Chitosan/Acrylic Polymers for Drug Delivery and Wound Dressing Applications

Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D

Exploring the therapeutic potential of Neem (Azadirachta Indica) for the treatment of prostate cancer: a literature review

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