Highlights d Cas9 ribonucleoproteins (RNPs) allow robust gene knockout in primary human monocytes d Cas9 RNP nucleofected monocytes can differentiate into macrophages or dendritic cells d Cas9 RNP nucleofected macrophages appropriately phagocytose M. tuberculosis d Knockout of the host factor SAMHD1 increased HIV infection of macrophages >503
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