Needleless coaxial electrospinning: A novel approach to mass production of coaxial nanofibers

Vysloužilová, Lucie; Buzgo, Matěj; Pokorný, Pavel; Chvojka, Jiří; Míčková, Andrea; Rampichová, Michala; Kula, Jiří; Pejchar, Karel; Bílek, Martin; Lukáš, David; Amler, Evžen

doi:10.1016/j.ijpharm.2016.11.034

Cited by 60 publications

(42 citation statements)

References 29 publications

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“…As the wire sweeps through the bath, it is first coated with the bottom liquid and then with the top liquid, forming a compound liquid layer which then breaks into compound droplets on the wire, producing core‐sheath fibers (Figure b). Another approach for nozzleless coaxial electrospinning was proposed using a weir spinneret and a slit spinneret (Figure d–e) . For the slit coaxial electrospinning, solutions are fed into the core and sheath slits separately and form multiple compound coaxial liquid jets, as shown in Figure f.…”

Section: Applied Coaxial Electrospinningmentioning

confidence: 99%

Coaxial Electrospinning Formation of Complex Polymer Fibers and their Applications

2019

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The formation of fibers by electrospinning has experienced explosive growth in the past decade, recently reaching 4,000 publications and 1,500 patents per year. This impressive growth of interest is due to the ability to form fibers with a variety of materials, which lend themselves to a large and rapidly expanding set of applications. In particular, coaxial electrospinning, which forms fibers with multiple core−sheath layers from different materials in a single step, enables the combination of properties in a single fiber that are not found in nature in a single material. This article is a detailed review of coaxial electrospinning: basic mechanisms, early history and current status, and an in‐depth discussion of various applications (biomedical, environmental, sensors, energy, catalysis, textiles). We aim to provide readers who are currently involved in certain aspects of coaxial electrospinning research an appreciation of other applications and of current results.

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Section: Applied Coaxial Electrospinningmentioning

confidence: 99%

Coaxial Electrospinning Formation of Complex Polymer Fibers and their Applications

2019

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“…However, their use is hampered by the low productivity of the process, reaching only about 0.001-0.1 g/h (Rutledge & Fridrikh, 2007;Theron, Zussman, & Yarin, 2004). The low productivity is caused by utilizing a needle method that supports the formation of a single jet per electrode (Vyslouzilova et al, 2016). The productivity of electrospinning could be improved by using numerous electrodes Release of growth factors from needleless emulsion nanofibres.…”

Section: Discussionmentioning

confidence: 99%

Needleless emulsion electrospinning for the regulated delivery of susceptible proteins

Buzgo

Filová

Staffa

et al. 2017

J Tissue Eng Regen Med

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In the present work, we developed a novel needleless emulsion electrospinning technique that improves the production rate of the core/shell production process. The nanofibres are based on poly-ε-caprolactone (PCL) as a continuous phase combined with a droplet phase based on Pluronic F-68 (PF-68). The PCL-PF-68 nanofibres show a time-regulated release of active molecules. Needleless emulsion electrospinning was used to encapsulate a diverse set of compounds to the core phase [i.e. 5-(4,6-dichlorotriazinyl) aminofluorescein -PF-68, horseradish peroxidase, Tetramethylrhodamine-dextran, insulin growth factor-I, transforming growth factor-β and basic fibroblast growth factor]. In addition, the PF-68 facilitates the preservation of the bioactivity of delivered proteins. The system's potential was highlighted by an improvement in the metabolic activity and proliferation of mesenchymal stem cells. The developed system has the potential to deliver susceptible molecules in tissue-engineering applications.

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“…However, the limited throughput of the needle spinneret means that the efficiency of polymer production using this technique is generally low [39]. Needleless electrospinning techniques represent a better way for high efficiency of polymer nanofiber production that can solve many of the limitations associated with traditional needle electrospinning techniques [40][41][42]. There are many methods for generating the surface disturbance of spinning solutions that is required for needless electrospinning, including ultrasonic disturbance, agitation, and acoustic bubble disturbance [43].…”

Section: Devices Used For Collagen Electrospinningmentioning

confidence: 99%

Electrospinning of Collagen and Its Derivatives for Biomedical Applications

Lü¹,

Guo²

2018

Novel Aspects of Nanofibers

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Collagen, gelatin and their derived polypeptides can act as multifunctional natural polymers with excellent physicochemical properties for biomedical applications. The use of electrospinning technology can convert collagen materials into nanofibrous materials that exhibit porous micro-nanostructures with good mechanical properties and excellent biocompatibility profiles. In this chapter, a systematic review of collagen electrospinning is presented and related applications are introduced including tissue engineering (e.g., artificial skin, artificial vasculature, cartilage repair, etc.), drug delivery, hemostatic dressings, periodontal restoration, biofilms, and wound dressings will now be discussed.

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Needleless coaxial electrospinning: A novel approach to mass production of coaxial nanofibers

Cited by 60 publications

References 29 publications

Coaxial Electrospinning Formation of Complex Polymer Fibers and their Applications

Coaxial Electrospinning Formation of Complex Polymer Fibers and their Applications

Needleless emulsion electrospinning for the regulated delivery of susceptible proteins

Electrospinning of Collagen and Its Derivatives for Biomedical Applications

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