Electrospinning of Collagen and Its Derivatives for Biomedical Applications

Lü, Wei; Guo, Yanchuan

doi:10.5772/intechopen.73581

Cited by 12 publications

(7 citation statements)

References 108 publications

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“…1,2 Electrospinning is an easy, versatility, and inexpensive method to prepare polymeric ultrane bers under the action of a high electrostatic eld from a wide variety of polymers. 3,4 Gelatin (Gt) is one of the most common biopolymers, and has been widely explored owing to its biodegradability, biocompatibility, immunogenicity proles, hydrophilic nature, and commercial availability at a low cost. 5 Poly(3caprolactone) (PCL) is a semi-crystalline linear hydrophobic polymer which is most commonly used for medical and environmental applications, owing to its biocompatibility and slow biodegradability.…”

Section: Introductionmentioning

confidence: 99%

Application of ANN modeling techniques in the prediction of the diameter of PCL/gelatin nanofibers in environmental and medical studies

Kalantary

Jahani²,

Pourbabaki

et al. 2019

RSC Adv.

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Prediction of the diameter of a nanofiber is very difficult, owing to complexity of the interactions of the parameters which have an impact on the diameter and the fact that there is no comprehensive method to predict the diameter of a nanofiber. Therefore, the aim of this study was to compare the multi-layer perceptron (MLP), radial basis function (RBF), and support vector machine (SVM) models to develop mathematical models for the diameter prediction of poly(3-caprolactone) (PCL)/gelatin (Gt) nanofibers.Four parameters, namely, the weight ratio, applied voltage, injection rate, and distance, were considered as input data. Then, a prediction of the diameter for the nanofiber model (PDNFM) was developed using data mining techniques such as MLP, RBFNN, and SVM. The PDNFM MLP is introduced as the most accurate model to predict the diameter of PCL/Gt nanofibers on the basis of costs and time-saving.According to the results of the sensitivity analysis, the value of the PCL/Gt weight ratio is the most significant input which influences PDNFM MLP in PCL/Gt electrospinning. Therefore, the PDNFM model, using a decision support system (DSS) tool can easily predict the diameter of PCL/Gt nanofibers prior to electrospinning.

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Section: Introductionmentioning

confidence: 99%

Application of ANN modeling techniques in the prediction of the diameter of PCL/gelatin nanofibers in environmental and medical studies

Kalantary

Jahani²,

Pourbabaki

et al. 2019

RSC Adv.

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“…Converting collagen into fibers offer good mechanical properties, porosity, and biocompatibility. They have been largely employed in tissue regeneration applications such as artificial skin graft, vasculature, tissue (cartilage) repair, periodontal restoration, and wound dressings [60].…”

Section: Natural Polymersmentioning

confidence: 99%

An overview on electrospinning and its advancement toward hard and soft tissue engineering applications

Muthukrishnan

2022

Colloid Polym Sci

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One of the emerging technologies of the recent times harboring nanotechnology to fabricate nanofibers for various biomedical and environmental applications are electrospinning (nanofiber technology). Their relative ease in use, simplicity, functionality and diversity has surpassed the pitfalls encountered with the conventional method of generating fibers. This review aims to provide an overview of electrospinning, principle, methods, feed materials, and applications toward tissue engineering. To begin with, evolution of electrospinning and its typical apparatus have been briefed. Simultaneously, discussion on the production of nanofibers with diversified feed materials such as polymers, small molecules, colloids, and nanoparticles and its transformation into a powerful technology has been dealt with. Further, highlights on the application of nanofibers in tissue engineering and the commercialized products developed using nanofiber technology have been summed up. With this rapidly emerging technology, there would be a great demand pertaining to scalability and environmental challenge toward tissue engineering applications.

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“…Fibrous mesh scaffolds composed of collagen can be formed using electrospinning methods. Due to the high surface area to volume ratio and porosity, collagen fibers are excellent for wound healing, drug and gene delivery, and tissue engineering skin [ 58 , 59 ]. Electrospinning of collagen solutions can result in a mesh-like pattern or highly aligned fibers, producing fibers at a nanometer scale that allows the matrix to mimic the structural and functional profile of in vivo collagen fibers [ 60 ].…”

Section: Pure Collagen I Matricesmentioning

confidence: 99%

Engineered Collagen Matrices

Patil

Masters

2020

Bioengineering

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Collagen is the most abundant protein in mammals, accounting for approximately one-third of the total protein in the human body. Thus, it is a logical choice for the creation of biomimetic environments, and there is a long history of using collagen matrices for various tissue engineering applications. However, from a biomaterial perspective, the use of collagen-only scaffolds is associated with many challenges. Namely, the mechanical properties of collagen matrices can be difficult to tune across a wide range of values, and collagen itself is not highly amenable to direct chemical modification without affecting its architecture or bioactivity. Thus, many approaches have been pursued to design scaffold environments that display critical features of collagen but enable improved tunability of physical and biological characteristics. This paper provides a brief overview of approaches that have been employed to create such engineered collagen matrices. Specifically, these approaches include blending of collagen with other natural or synthetic polymers, chemical modifications of denatured collagen, de novo creation of collagen-mimetic chains, and reductionist methods to incorporate collagen moieties into other materials. These advancements in the creation of tunable, engineered collagen matrices will continue to enable the interrogation of novel and increasingly complex biological questions.

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Electrospinning of Collagen and Its Derivatives for Biomedical Applications

Cited by 12 publications

References 108 publications

Application of ANN modeling techniques in the prediction of the diameter of PCL/gelatin nanofibers in environmental and medical studies

Application of ANN modeling techniques in the prediction of the diameter of PCL/gelatin nanofibers in environmental and medical studies

An overview on electrospinning and its advancement toward hard and soft tissue engineering applications

Engineered Collagen Matrices

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