Needle-Shaped Deposits on Retinal Surface in a Case of Ocular Amyloidosis

Abstract

In this case, OCT showed needle-shaped deposits perpendicular to the retinal surface. Special staining with Congo red revealed the deposit to be amyloid deposition. Immunohistochemical staining suggested light chain-related amyloidosis. Vascular obstructive lesions and neovascular glaucoma secondary to retinal vascular damage in amyloidosis warrant particular attention.

Multimodal retinal imaging in a Chinese kindred with familial amyloid polyneuropathy secondary to transthyretin Ile107Met mutation

“…This observation may be attributed to the fact that most of these deposits were removed during vitrectomy. Other findings such as retinal hemorrhages that have been reported previously [9][10][11] were absent in our case. These deviations suggested clinical heterogeneity of vitreous amyloidosis.…”

“…It was previously reported that the needle-shaped deposits perpendicular to the retinal surface are oriented towards the vitreous on the OCT. 11 These deposits were extensively found on the macula in the reported literature; 11 however, they were limited to the perifoval region in our case. This observation may be attributed to the fact that most of these deposits were removed during vitrectomy.…”

“…8 Some patients have retinal neovascularization and hemorrhage. [9][10][11] Although the vitreous opacity can be removed by vitrectomy, there is recurrence in some cases. 12 We report the ocular phenotypes using multimodal imaging techniques and genetic analysis in a Chinese kindred with FAP and vitreous amyloidosis.…”

Multimodal Imaging of the Retina and Choroid in Systemic Amyloidosis

“…Ophthalmic manifestations of systemic amyloidosis include deposition into the eyelid, conjunctiva, lacrimal gland, vitreous, all layers of the retina, and in vessels of the retina and choroid. [3][4][5][6][7][8] We present four patients with systemic amyloidosis (one primary and three secondary) and renal failure, which demonstrate consistent and characteristic chorioretinal findings with multimodal imaging.…”

Ocular Presentations of Amyloidosis

“…Glaucoma as an independent condition in vitreous amyloidosis or concurrently developed complication, can be managed with filtering surgery at the time of vitrectomy or at any time postoperatively. [43][44][45][46][47][48][49][50][51][52][53][54][55]…”