Ocular Presentations of Amyloidosis

Hashemian, Hesam; Jabbarvand, Mahmoud; Khodaparast, Elias Khalilipour Mehdi; Esfehani, Hamid Riazi

doi:10.5772/53910

Cited by 11 publications

(9 citation statements)

References 77 publications

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“…Conjunctival deposits are usually painless but may gradually grow in size causing a significant local swelling and irritation. Recurrent subconjunctival hemorrhages have been reported to be associated with conjunctival amyloidosis and it is believed to be due to increased fragility of orbital vasculature secondary to amyloid deposits [13]. …”

Section: Discussionmentioning

confidence: 99%

“…The most common reported signs and symptoms include visible or palpable periocular mass or tissue infiltration and ptosis. Other reported signs and symptoms include pain or periocular discomfort, recurrent periocular subcutaneous hemorrhages, ocular motility disturbances, proptosis, diplopia, and globe displacement [13, 14]. The clinical picture and morphologic appearance alone are not enough to make a diagnosis of conjunctival amyloidosis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ectropion and Conjunctival Mass in a Patient with Primary Bilateral Conjunctival Amyloidosis

Meduri

Rechichi

Mazzotta

et al. 2016

Case Reports in Ophthalmological Medicine

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Background. Amyloidosis is a group of disorders characterized by deposition of an extracellular protein, known as amyloid, in an abnormal fibrillar form with highly characteristic histopathologic staining properties. The clinical presentation can vary from a focal, localized lesion where amyloidosis has minor clinical consequences to extensive systemic disease that can involve any organ system of the body. Ocular amyloidosis can occur as a localized lesion or as a part of a systemic disorder. Conjunctival amyloidosis is an uncommon condition that is rarely associated with systemic disease. It may be a manifestation of an immunologic disorder. Case Report. We report the case of a patient with bilateral conjunctival amyloidosis who was referred to us with the suspicion of a malignant conjunctival lesion. Examination of both eyes showed a yellow-pink mass with prominent intrinsic vessels, subconjunctival hemorrhage, and ectropion of the left lower eyelid. Diagnosis of primary localized conjunctival amyloidosis was made based on histopathologic evaluation of incisional biopsy and negative systemic work-up. Conclusion. Ocular amyloidosis is a rare disease that is slowly progressive and has a wide variety of clinical presentations. Consequently, the clinical diagnosis is often overlooked or delayed. Definitive diagnosis is achieved through histopathologic evaluation of biopsy specimen.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ectropion and Conjunctival Mass in a Patient with Primary Bilateral Conjunctival Amyloidosis

Meduri

Rechichi

Mazzotta

et al. 2016

Case Reports in Ophthalmological Medicine

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show abstract

“…The results are shown in Table 5. [5,10,11,14] External protection function 2 [6,8,9,12,13,16,19,20,23,25] Internal support function 3 [2,3,24] Lifting function 4 [15,17,21] Assembly assistance function 5 [1,4,7,18,22] Auxiliary connection function…”

Section: Establishment Of Mathematical Modelmentioning

confidence: 99%

“…For the moment, many experts and scholars have studied module partition. GU et al [8] pointed out the life cycle factors related to design objectives, and proposed a method about the integrated and module for product life. Cycle Han et al [9] made a research on component model and its model repurposing, proposing a new method about module division for mechanical CAD component model.…”

Section: Introductionmentioning

confidence: 99%

Green Product Module Partition Method Based on Improved Multi-objective Artificial Bee Colony Algorithm

Wei

Zhan

2019

MATEC Web Conf.

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Modular design is an important design method in the mass customization for manufacturing industry. The purpose of this paper is to meet diverse market demands while reducing the impact of products on the ecological environment. Firstly, aiming at the product life cycle process, this paper summarizes the problems encountered in each stage of the product, and introduces five green product module partition principles. Then, through the component correlation matrix, the resource greenness objective function based on the whole life cycle and the polymerization degree objective function based on the component correlation matrix are established respectively by the axiomatic design theory which makes the product mapping from functional domain to structural domain. Next, an improved artificial bee colony algorithm is proposed. Based on the artificial bee colony algorithm, the algorithm applies congestion strategy and fast nondominated sorting strategy to solve the module partition problem of product platform with multi-objective optimization, and a uniformly distributed pareto solution set is generated. Through above steps, the optimization results of module partition are obtained. Finally, an application example of aircraft tail horizontal stabilizer parts is given, and the advantages of the algorithm are proved by comparing with other algorithms.MATEC Web of Conferences 301, 00021 (2019) 9In the formula (9) , K(a,b) is the polymerization degree between the part a and the part b. Calculation of internal polymerization degree and external polymerization degreeAccording to the correlation matrix of product parts, internal polymerization degree of module k is as follows:

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“…The incidence of vitreous opacities in familial amyloidosis polyneuropathy varies from 5.4 to 35%. [4,5]. Vitreous amyloidosis is almost always related to mutant transthyretin, which is a plasma protein carrier of thyroxine and vitamin [5].…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein AI-Derived Vitreous Amyloidosis: An Elusive Diagnosis

Yépez

Murati

Petitto

et al. 2020

Case Rep Ophthalmol

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A 56-year-old female presented with vitreous opacity with gradual visual disturbance in her right eye of 1-year duration. A Non-Hodgkin's lymphoma had been treated 15 years before. Presenting best-corrected visual acuity (BCVA) was 20/200 in her right eye and 20/25 in her left eye. Intraocular pressure was 18 mm Hg bilaterally. Slit-lamp examination revealed no abnormal findings in the anterior segment of both eyes, including the absence of cells and flare. Fundoscopic examination indicated hazy media with the typical glass-wool-like appearance in her right eye. B-scan ultrasound demonstrated that the vitreous was full of middle-echo spots, vitreous opacities, and posterior vitreous detachment occurred. The patient underwent vitreous biopsy and a standard 25-gauge pars plana vitrectomy (diagnostic and therapeutic). Intraoperatively, the eye was noted to have severe diffuse debris and very strong vitreoretinal adhesions. Cytospin smears prepared from the vitreous aspirate indicated amorphous acellular material that stained positively with Congo Red and showed apple green birefringence on polarized microscopy, consistent with the diagnosis of amyloidosis. A genetic evaluation of tongue tissue demonstrated apolipoprotein AI-derived amyloidosis. The BCVA was 20/25 OU at 3 months postoperatively.

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Ocular Presentations of Amyloidosis

Cited by 11 publications

References 77 publications

Ectropion and Conjunctival Mass in a Patient with Primary Bilateral Conjunctival Amyloidosis

Ectropion and Conjunctival Mass in a Patient with Primary Bilateral Conjunctival Amyloidosis

Green Product Module Partition Method Based on Improved Multi-objective Artificial Bee Colony Algorithm

Apolipoprotein AI-Derived Vitreous Amyloidosis: An Elusive Diagnosis

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