Multimodal imaging including spectral domain optical coherence tomography analysis in eyes of patients with systemic amyloidosis shows deposition in the choroid. The deposition may cause a secondary toxic and or barrier effect resulting in diffuse retinal pigment epithelium and photoreceptor dysfunction.

Congenital retinal macrovessel has been classified as a subtype of retinal arterial–venous malformation. However, no association with intracranial vascular malformation has previously been reported. Here, the authors report a case of congenital retinal macrovessel complicated by cystoid macular edema and associated with an ipsilateral intracranial venous malformation.

This report provides evidence that optical coherence tomography angiography may be more sensitive in detecting macular capillary nonperfusion than fluorescein angiography. It also provides further evidence that the ischemic vasculopathy of sickle cell retinopathy preferentially affects the deep capillary plexus.

Ultra-widefield FA using the Optos camera is helpful for the evaluation and management of patients with von Hippel-Lindau disease. The UWF FA with gaze steering appears to detect more hemangioblastomas than ophthalmoscopy and conventional angiography.

In patients with the mitochondrial DNA point mutation A3243G, corneal endothelial polymegathism is present. This is mainly associated with mild guttata. The findings of corneal endothelial cell polymegathism may be a biomarker of mitochondrial disease, specifically in patients with the mitochondrial DNA A3243G mutation.