Necrosis of the adrenal cortex and adrenal capsular myoarteritis in a dog

Kelly, DF

doi:10.1136/vr.77.35.998

Cited by 8 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dogs may have 2 morphologically different types of arterial lesions, in both of which there is necrosis of the vessel wall. The most common is myoarteritis (21,34) or plasmatic vasculosis (1) affecting predominantly intrarenal arteries and afferent arterioles with less frequent involvement ofvessels in myocardium, tongue, adrenal ( Fig. 9), and gastric submucosa.…”

Section: Necrosis This Describes Irreversible Cell Deathmentioning

confidence: 99%

See 1 more Smart Citation

Classification of Naturally Occurring Arterial Disease in the Dog

Kelly

1989

Toxicol Pathol

View full text Add to dashboard Cite

Evaluation of induced arterial toxicity in safety assessment of drugs involves recognition of morphologic differences between groups of animals. In this organ system, as in all others, it is necessary to be familiar with the background pathology that can occur in control animals of the test species, since such lesion "noise" may complicate the evaluation of drug-related effects if naturally occurring diseases have morphologic features in common with those that can be produced by drugs. Background arterial lesions have been regarded as relatively unimportant in both the laboratory-maintained beagle and in the larger range of domesticated breeds of dog and few of these vascular lesions lead, per se, to functional organ compromise. At least this appears to be the case in young and middle-aged subjects, within the epidemiologic limits of data from veterinary medical centers where systematic and thorough necropsies are done and recorded. Arterial lesions are, however, not uncommon naturally occurring incidental necropsy findings in dogs; however, in most cases they are of uncertain functional significance. This presentation summarizes the main pathologic patterns of lesions that can affect arteries in dogs that are not used in safety evaluation studies. The main patterns can be classified as degenerative, proliferative, and inflammatory, although there is some overlap between these partly arbitrary designations. In some cases, etiopathogenesis of the arterial lesion is unclear; in others, there are clear associations with disease processes in other organ systems. Congenital vascular lesions and vascular components of congenital cardiac defects are excluded from consideration since such lesions are unlikely to occur in dog populations used in the safety assessment of drugs.

show abstract

Section: Necrosis This Describes Irreversible Cell Deathmentioning

confidence: 99%

“…-Myoarteritis in adrenal capsule ofa 6-yr-old boxer dog with chronic interstitial nephritis(21). There is fibrinoid necrosis of tunica media and adventitial inflammation.…”

mentioning

confidence: 99%

Classification of Naturally Occurring Arterial Disease in the Dog

Kelly

1989

Toxicol Pathol

View full text Add to dashboard Cite

show abstract

“…A current list of causes in the dog and cat, with some pertinent references, includes: Glomerulonephritis (Obel et (Platt 1952a;McGill et a1 1958;Kelly 1965) It has been shown, clinically, that a critical situation is reached in the dog and cat when approximately two-thirds of the nephrons of the kidneys have been destroyed by a chronic disease process, regardless of the cause. After removal of three-quarters of their renal tissue mass, dogs lost the ability to concentrate urine, but retained the ability to excrete larger amounts of urea than were normally necessary (Bradford 1899).…”

Section: Aetidogymentioning

confidence: 99%

Chronic Renal Failure in the Dog and Cat*

1973

Aust Veterinary J

View full text Add to dashboard Cite

“…(7) Cardiovascular efects and anaemia. Degenerative changes in the arteries and heart may follow the hypertension of chronic interstitial nephritis (Kelly, 1965 ;Anderson, 1968). I n cases of cardiac hypertrophy digoxin therapy is usually instituted, although, because of the reduced rate of excretion of cardiac glycosides, the normal therapeutic dose should be decreased (Kerr & Walls, 1970).…”

Section: T R E a T M E N T (A) Cowervative Measures F O R The Effectsmentioning

confidence: 99%

Essential features of the treatment of chronic renal failure in the dog*

Bush

1971

J of Small Animal Practice

View full text Add to dashboard Cite

The consequences of chronic renal failure are enumerated and the recommended measures for mitigating them are described. Treatments vary according to whether the disease is in the compensated or terminal phase. Résumé. On énumère les conséquences des maladies rénales chroniques et on décrit les mesure recommandées pour les atténuer. La traitements varient selon que la maladie se trouve au stade compensé ou terminal. Zusammenfassung. Die Folgen chronischen Nierenversagens werden aufgezählt und die empfohlenen Massnahmen zu ihrer Linderung beschrieben. Die Behandlung richtet sich danach, ob die Krankheit sich in der Kompensationsoder terminalen Phase befindet.

show abstract

Necrosis of the adrenal cortex and adrenal capsular myoarteritis in a dog

Cited by 8 publications

References 0 publications

Classification of Naturally Occurring Arterial Disease in the Dog

Classification of Naturally Occurring Arterial Disease in the Dog

Chronic Renal Failure in the Dog and Cat*

Essential features of the treatment of chronic renal failure in the dog*

Contact Info

Product

Resources

About