Near-infrared mediated tumor destruction by photothermal effect of PANI-Np<i>in vivo</i>

Ibarra, Luis Exequiel; Yslas, Edith Inés; Molina, María; Rivarola, Claudia R.; Romanini, Silvia; Barbero, C.; Rivarola, Viviana; Bertuzzi, Mabel

doi:10.1088/1054-660x/23/6/066004

Cited by 27 publications

(29 citation statements)

References 27 publications

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“…These results suggest that the combination of nanoparticles and radiation triggers cell death by apoptosis in attached cells. Promising results with these nanoparticles were obtained in our laboratory for in vivo assays with apoptosis and necrosis as the responsible mechanisms of cell death (Ibarra et al 2013). Previous studies of polyaniline nanoparticles in PTT showed similar results in different cancer cell lines (Yang et al 2011;Zhou et al 2013).…”

Section: Laser Treatment Of Tumor Cells With Pani-npsmentioning

confidence: 77%

“…However, the major issue with these types of nanomaterials is their low biocompatibility, particularly their long-term toxicity, which limits their clinical application (Balasubramanian et al 2010;Zhang et al 2011). Recently, we have demonstrated that polyaniline nanoparticles are very effective for in vivo photothermal therapy, and have nontoxic effects and a good tolerance (Ibarra et al 2013. Polyaniline is one of the most promising conducting organic polymers because of its low cost, facile synthesis, high conductivity, and environmental and chemical stabilities (Heeger 1993;Stejskal and Sapurina 2005;Stejskal and Proke 2014).…”

Section: Introductionmentioning

confidence: 99%

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Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

et al. 2015

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Polyaniline nanoparticles (PANI-Nps) have been used in several applications; however, there are few publications related to the use in the photothermal therapy. PANI-Nps have high optical absorbance in the near-infrared region and in this wavelength range, biological systems are relatively transparent. For this reason, these materials can be used to absorb energy and to generate heat that destroys cancer cells selectively. PANI-Nps with average size of ca. 200 nm and neutral zeta potential were synthesized and characterized by DLS, SEM, and zeta potential. The kinetics of incorporation of PANINps into LM2 cell line was monitored using UV-Vis spectrophotometry. The analysis of cell viability after PANI-Nps exposure shows that these nanoparticles are not cytotoxic even at high concentration and show no change in cell morphology and metabolic activity. Furthermore, we found that nanoparticle cell uptake reaches the maximum value c.a. 3 h after incubation. Cells were targeted by Pani-Nps and irradiated, resulting in significant elevation of intracellular ROS and heat production. One of the mechanisms of PANINps-mediated photothermal killing of cancer cells apparently involved oxidative stress resulting in apoptotic cell death.

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Section: Laser Treatment Of Tumor Cells With Pani-npsmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

et al. 2015

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“…The temperature change is enough to induce cell death of tumoral cells because those cells have a diminished functionality of the DNS repair systems, correlated with its increased growth rate. Indeed, it has been shown that excellent photothermal therapy efficacy is achieved in-vivo upon intratumoral injection of PANI NPs followed by nearinfrared light exposure [35]. The results suggested that PANI NPs could be considered as an effective photothermal agent and pave the way to future cancer therapeutics.…”

Section: Photothermal Effect By Near Infrared Radiation Absorptionmentioning

confidence: 99%

Smart polyaniline nanoparticles with thermal and photothermal sensitivity

et al. 2014

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Conductive polyaniline nanoparticles (PANI NPs) are synthesized by oxidation of aniline with persulfate in acid media, in the presence of polymeric stabilizers: polyvinilpyrrolidone (PVP), poly(N-isopropylacrylamide) (PNIPAM), and hydroxylpropylcellulose (HPC). It is observed that the size of the nanoparticles obtained depends on the polymeric stabilizer used, suggesting a mechanism where the aggregation of polyaniline molecules is arrested by adsorption of the polymeric stabilizer. Indeed, polymerization in the presence of a mixture of two polymers having different stabilizing capacity (PVP and PNIPAM) allows tuning of the size of the nanoparticles. Stabilization with biocompatible PVP, HPC and PNIPAM allows use of the nanoparticle dispersions in biological applications. The nanoparticles stabilized by thermosensitive polymers (PNIPAM and HPC) aggregate when the temperature exceeds the phase transition (coil to globule) temperature of each stabilizer (Tpt = 32 °C for PNIPAM or Tpt = 42 °C for HPC). This result suggests that an extended coil form of the polymeric stabilizer is necessary to avoid aggregation. The dispersions are reversibly restored when the temperature is lowered below Tpt. In that way, the effect could be used to separate the nanoparticles from soluble contaminants. On the other hand, the PANI NPs stabilized with PVP are unaffected by the temperature change. UV-visible spectroscopy measurements show that the nanoparticle dispersion changes their spectra with the pH of the external solution, suggesting that small molecules can easily penetrate the stabilizer shell. Near infrared radiation is absorbed by PANI NPs causing an increase of their temperature which induces the collapse of the thermosensitive polymer shell and aggregation of the NPs. The effect reveals that it is possible to locally heat the nanoparticles, a phenomenon that can be used to destroy tumor cells in cancer therapy or to dissolve protein aggregates of neurodegenerative diseases (e.g. Alzheimer). Moreover, the long range control of aggregation can be used to modulate the nanoparticle residence inside biological tissues.

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“…In a variety of research fields involving PTT, the design and development of PTT agents with tissue‐transparent near‐infrared (NIR) absorption properties has attracted widespread interest, which is important for achieving future clinical implementation . Currently available PTT agents mainly include two types of nanomaterials: inorganic nanomaterials, such as Cu‐, Au‐,[4b,8] Pd‐, carbon‐based nanomaterials, as well as a few others, and organic conjugated polymer‐based nanomaterials, such as polyaniline (PANI)‐, polypyrrole‐, polythiophene‐, and polydopamine‐based nanoparticles . Recently, inorganic nanomaterial‐based PTT agents have been utilized to photoablate melanoma .…”

Section: Introductionmentioning

confidence: 99%

Poly(N‐phenylglycine)‐Based Nanoparticles as Highly Effective and Targeted Near‐Infrared Photothermal Therapy/Photodynamic Therapeutic Agents for Malignant Melanoma

Jiang

Zhang

Guo

et al. 2016

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A novel plasmonic gold nanocarrier using a modular RNA scaffold significantly improves delivery efficiency into diverse human cells, as presented by Norbert O. Reich and co-workers in article number 1602473. The orthogonal positioning of cell targeting peptides and functional RNA provides unprecedented control in the delivery of biologically active RNA. NIR light-triggered RNA release with spatio-temporal control further enhances the RNA delivery efficiency. Plasmon-Enhanced Spectroscopy Shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) is invented to break the long-standing material-and substrate-specific limitations in SERS (surface-enhanced Raman scattering), as presented by Jian-Feng Li and co-workers in article number 1601598. The metal nanoparticle acts as a plasmonic nanoantenna for near field amplification, and the ultra-thin dielectric shell prevents the interference of environmental species. Single Crystals Perovskite single-crystalline microplate arrays are fabricated on a large scale via inkjet printing technology by Mingzhu Li, Yanlin Song, and co-workers in article number 1603217. By modulating the inkjet droplet volume and the ink composition, a tunable single/multiple mode laser with high quality factors up to 863 and three primary-color microplates are achieved. This work makes a great step toward the multifunction of on-chip perovskite crystals, which can boost its promising applications on integrated coherent light sources and other optoelectronic applications. Recent progress in the development of metallofullerene nanomaterials for next-generation biomedical applications is reviewed. For example, the metallo-fullerenes are promising magnetic resonance imaging contrast agents, which are attractive by shielding toxic metals from the bioenviroment. This nanoplatform readily allows specific targeting and multi-modality capability for both diagnostic and therapeutic applications. reviews Shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) has been invented to break the long-standing material-and substrate-specific limitations in conventional SERS. The noble metal nanoparticle acts as plasmonic nanoantenna for the near field amplification , and the ultra-thin and inert dielectric shell prevents the interference of environmental species. This SHINERS concept could be applied to a lager family of surface-enhanced spectroscopies. Catalysts Hydrogen is considered as sustainable and environmentally friendly energy for global energy demands in the future. Here a Co-FeS 2 catalyst with surface phosphide doping (P/Co-FeS 2) for hydrogen evolution reaction (HER) in acidic solutions is developed. The P/Co-FeS 2 exhibits superior HER electrochemical performance with overpotential of-90 mV at 100 mA cm-2 and Tafel slope of 41 mV/decade and excellent durability. communications MWCNTs self-assemble into various homocentric rings in a thermo-driven self-assembly system. Closely packed and scatteredly packed MWCNT rings self-assemble on a Si-SiO 2 substrate, whereas on a Au substrate ...

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Near-infrared mediated tumor destruction by photothermal effect of PANI-Npin vivo

Cited by 27 publications

References 27 publications

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

Smart polyaniline nanoparticles with thermal and photothermal sensitivity

Poly(N‐phenylglycine)‐Based Nanoparticles as Highly Effective and Targeted Near‐Infrared Photothermal Therapy/Photodynamic Therapeutic Agents for Malignant Melanoma

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