Poly(N‐phenylglycine)‐Based Nanoparticles as Highly Effective and Targeted Near‐Infrared Photothermal Therapy/Photodynamic Therapeutic Agents for Malignant Melanoma

Abstract

A novel plasmonic gold nanocarrier using a modular RNA scaffold significantly improves delivery efficiency into diverse human cells, as presented by Norbert O. Reich and co-workers in article number 1602473. The orthogonal positioning of cell targeting peptides and functional RNA provides unprecedented control in the delivery of biologically active RNA. NIR light-triggered RNA release with spatio-temporal control further enhances the RNA delivery efficiency. Plasmon-Enhanced Spectroscopy Shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) is invented to break the long-standing material-and substrate-specific limitations in SERS (surface-enhanced Raman scattering), as presented by Jian-Feng Li and co-workers in article number 1601598. The metal nanoparticle acts as a plasmonic nanoantenna for near field amplification, and the ultra-thin dielectric shell prevents the interference of environmental species. Single Crystals Perovskite single-crystalline microplate arrays are fabricated on a large scale via inkjet printing technology by Mingzhu Li, Yanlin Song, and co-workers in article number 1603217. By modulating the inkjet droplet volume and the ink composition, a tunable single/multiple mode laser with high quality factors up to 863 and three primary-color microplates are achieved. This work makes a great step toward the multifunction of on-chip perovskite crystals, which can boost its promising applications on integrated coherent light sources and other optoelectronic applications. Recent progress in the development of metallofullerene nanomaterials for next-generation biomedical applications is reviewed. For example, the metallo-fullerenes are promising magnetic resonance imaging contrast agents, which are attractive by shielding toxic metals from the bioenviroment. This nanoplatform readily allows specific targeting and multi-modality capability for both diagnostic and therapeutic applications. reviews Shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) has been invented to break the long-standing material-and substrate-specific limitations in conventional SERS. The noble metal nanoparticle acts as plasmonic nanoantenna for the near field amplification , and the ultra-thin and inert dielectric shell prevents the interference of environmental species. This SHINERS concept could be applied to a lager family of surface-enhanced spectroscopies. Catalysts Hydrogen is considered as sustainable and environmentally friendly energy for global energy demands in the future. Here a Co-FeS 2 catalyst with surface phosphide doping (P/Co-FeS 2) for hydrogen evolution reaction (HER) in acidic solutions is developed. The P/Co-FeS 2 exhibits superior HER electrochemical performance with overpotential of-90 mV at 100 mA cm-2 and Tafel slope of 41 mV/decade and excellent durability. communications MWCNTs self-assemble into various homocentric rings in a thermo-driven self-assembly system. Closely packed and scatteredly packed MWCNT rings self-assemble on a Si-SiO 2 substrate, whereas on a Au substrate ...

Multistage Targeting Strategy Using Magnetic Composite Nanoparticles for Synergism of Photothermal Therapy and Chemotherapy

“…Since melanomas can easily develop resistance to conventional chemotherapeutics, they are always associated with a very poor prognosis . Thus, the development of novel therapeutic methods for the treatment of malignant melanoma is a pressing need . Photothermal therapy (PTT) has been a promising therapeutic strategy for patients with melanomas due to its noninvasive, highly selective, and controllable treatment features .…”

“…The UV–vis absorption spectrum also showed the changes in the nanoparticles during the synthesis (Figure F). From the UV–vis absorption spectrum, it can be seen that, after coating the Fe 3 O 4 CNCs with PDA, the nanoparticles possessed a broad absorption in the NIR region; after grafting with mPEG and TPP, the absorption of the nanoparticles in the NIR region changed little, which is favorable for PTT . Considering the absorbance across the whole NIR region, Fe@PDA–TPP/SS could rapidly convert the light absorbed at NIR wavelengths into thermal energy …”

Polymer Dots as Effective Phototheranostic Agents

“…developed and synthesized a new class of PNPG‐based Pdot agents for the treatment of malignant melanoma (Fig. d) . In this work, PNPG exhibited pH‐responsive NIR absorption, photothermal effect (Fig.…”

“…(f) ROS generation of PNPG‐PEG‐HA. Reproduced with permission from ref . Copyright 2017 Wiley‐VCH Verlag GmbH & Co. KGaA.…”

New developments and clinical transition of hyaluronic acid-based nanotherapeutics for treatment of cancer: reversing multidrug resistance, tumour-specific targetability and improved anticancer efficacy

“…The quest for development of novel therapeutic strategies for treatment of melanoma led to preparation of polymerbased photo-thermal agents derived from poly-N-phenylglycine (PNPG), (prepared though N-phenylglycine (NPG) polymerization) for employment in NIR-mediated-phototherapy and generating ROS upon irradiation [56]. PNPG was further conjugated with HA as a targeting ligand and PEG-diamine as a potential coupling agent.…”