Near-Infrared-Light-Responsive Magnetic DNA Microgels for Photon- and Magneto-Manipulated Cancer Therapy

Wang, Yitong; Wang, Ling; Yan, Miaomiao; Dong, Shuli; Hao, Jingcheng

doi:10.1021/acsami.7b05502

Cited by 43 publications

(39 citation statements)

References 56 publications

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“…The amount of Dox released was measured at 37 °C. Buffer solution (4 mL) was taken out from the buffer solution outside the dialysis bag for UV-visible spectrophotometer detection (detection wavelength is 485 nm) at different times (1,2,4,8,12,24,36,48,72,84,96,108, and 120 h), whereas 4 mL fresh buffer solution was added into the buffer solution outside the dialysis bag.…”

Section: The Release Behavior Of Dox From the La-peg-g-dox Nanomedicinementioning

confidence: 99%

“…Moreover, the side effects of chemotherapy are seriously large and toxic due to the nonspecificity treatment of anticancer drugs. Therefore, new green therapies need to be discovered to reduce the side effects of traditional cancer treatment is an urgent problem to be solved [2] . Various drug carriers provide a solution to the above problems [3][4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

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Delay Tumor Growth Properties of LA-PEG-G Molecule and Its' Application as Drug Carrier

Wei¹,

Xin²,

Wang³

et al. 2020

Preprint

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LA–PEG–G molecule was prepared through the covalent conjugation of linoleic acid, polyethylene glycol and guanosine. LA–PEG–G molecule can self-assemble into spherical aggregate in aqueous solution. The size of the LA–PEG–G aggregate was approximately 132.1 ± 13.718 nm, and the Zeta potential was −36.3 ± 0.9644 mv. The loading rate of LA–PEG–G aggregates to Dox was 84.62 ± 1.810%. In vitro release experiments showed that Dox release from the LA–PEG–G–Dox nanomedicine was slow-release. Cell experiments showed that LA–PEG–G aggregates have low cytotoxicity, and the relative cancer cells survival rate decreased with the increasing of time and LA–PEG–G–Dox nanomedicine concentration. In vivo experiments showed that LA–PEG–G–Dox nanomedicine can inhibit tumor growth, and the LA–PEG–G aggregate could also delay the tumor growth which is very important to play the synergistic antitumor effect with the anticancer drug. Serum biochemistry showed that LA–PEG–G–Dox nanomedicine which reduced the Dox toxicity had very good antitumor effect. The tumor tissue sections indicated that LA–PEG–G–Dox nanomedicine can effectively induce tumor cell apoptosis, and finally cause tissue necrosis to achieve tumor treatment.

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Section: The Release Behavior Of Dox From the La-peg-g-dox Nanomedicinementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Delay Tumor Growth Properties of LA-PEG-G Molecule and Its' Application as Drug Carrier

Wei¹,

Xin²,

Wang³

et al. 2020

Preprint

Self Cite

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“…Taking advantage of this, a wide variety of chromophores including spiropyrans, o ‐nitrobenzyl derivatives, and azobenzene have been utilized to develop light‐sensitive polymers . Recently, increasing attempts have been made to synthesize microgel systems with chromophores included in their network to explore the potential of light stimulus for drug delivery applications …”

Section: Microgels For Drug Delivery Applicationmentioning

confidence: 99%

“…[121][122][123] In this regard, magnetic nanoparticle-loaded thermoresponsive microgels are of particular interest as the temperature change generated by applying an external alternating current magnetic field can lead to remote controlled drug release without the need of any additional stimuli. [124,125] Among a wide variety of magnetic nanoparticles, iron oxides are of particular interest as they are approved by the Food and Drug Administration (FDA). [126] Feridex,Resovist, and Ferumoxtran-10 are some examples of commercially available magnetic resonance imaging (MRI) contrast agents based on magnetite (Fe 3 O 4 ) nanoparticles coated with dextran and its derivatives.…”

Section: Remotely Controlled Microgels For Drug Deliverymentioning

confidence: 99%

“…[138][139][140] Recently, increasing attempts have been made to synthesize microgel systems with chromophores included in their network to explore the potential of light stimulus for drug delivery applications. [125] Light-responsive, 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized Konjac Glucomannan (OKGM)-based delivery system was fabricated by Chen et al [135] The microspheres were stabilized by interaction between carboxylic (COO − ) groups and Fe 3+ ions. The developed system showed degradation when exposed to sunlight, thus showing its potential for light-switched release of encapsulated substances.…”

Section: Remotely Controlled Microgels For Drug Deliverymentioning

confidence: 99%

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Functional Microgels: Recent Advances in Their Biomedical Applications

Agrawal

2018

Small

119

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Here, a spotlight is shown on aqueous microgel particles which exhibit a great potential for various biomedical applications such as drug delivery, cell imaging, and tissue engineering. Herein, different synthetic methods to develop microgels with desirable functionality and properties along with degradable strategies to ensure their renal clearance are briefly presented. A special focus is given on the ability of microgels to respond to various stimuli such as temperature, pH, redox potential, magnetic field, light, etc., which helps not only to adjust their physical and chemical properties, and degradability on demand, but also the release of encapsulated bioactive molecules and thus making them suitable for drug delivery. Furthermore, recent developments in using the functional microgels for cell imaging and tissue regeneration are reviewed. The results reviewed here encourage the development of a new class of microgels which are able to intelligently perform in a complex biological environment. Finally, various challenges and possibilities are discussed in order to achieve their successful clinical use in future.

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Advances in MEMS and Microfluidics‐Based Energy Harvesting Technologies

Mahmud

Bazaz

Dabiri

et al. 2022

Adv Materials Technologies

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harvesters that can replace conventional energy sources. [1] Microelectronic devices use small rechargeable or nonrechargeable batteries as their primary source of power. However, these batteries have a limited and uncertain lifetime, have difficulty replacing, and hence maintenance intensive. Energy harvesting devices are becoming an increasingly viable solution and may one day replace conventional batteries in low power applications. [2] Microfluidics analysis is one of the important research fields in MEMS, exhibiting broad market prospects due to characteristics, e.g., flexibility and the ability of rapid thermal transport. [3] Microfluidic devices are remarkably flexible and can be stretched in shape and size, allowing them to convert the deformation of the material into electricity. [4] It makes them capable of integrating the MEMS-based energy harvesters in self-powered sensors [5] located in various environments, such as the human body. [6] Also, microfluidics technology can be used for increasing the performance efficiency of energy harvesters by using as a heat exchanger [7] or embedding in the housing system. [8] Also, MEMS technology, which allows microscale structures to be fabricated inside energy harvesting devices, has enormously improved harvesting methods. It is a microstructure that ensures physical interactions happen in a tiny space so that the size of the harvester can be minimized and energy density can be improved.

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Near-Infrared-Light-Responsive Magnetic DNA Microgels for Photon- and Magneto-Manipulated Cancer Therapy

Cited by 43 publications

References 56 publications

Delay Tumor Growth Properties of LA-PEG-G Molecule and Its' Application as Drug Carrier

Delay Tumor Growth Properties of LA-PEG-G Molecule and Its' Application as Drug Carrier

Functional Microgels: Recent Advances in Their Biomedical Applications

Advances in MEMS and Microfluidics‐Based Energy Harvesting Technologies

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