Naturally Occurring Plant Coumarins

Murray, R. D. H.

doi:10.1007/978-3-7091-6527-0_1

Cited by 38 publications

(20 citation statements)

References 212 publications

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“…1). Both physical and spectral parameters of this compound coincided with those reported by Murray (1978), Harborne (1989), and Pouchert (1993). Coumarins have been reported to have different biological effects such as antibiotic and phytotoxic activity; they can produce hepatic damage, and so forth (Harborne, 1989).…”

Section: Determination Of Mic and Mbcsupporting

confidence: 87%

Antimicrobial Activity of Alternanthera caracasana.

Canales-Martínez

Hernández-Delgado

Flores-Ortíz

et al. 2005

Pharmaceutical Biology

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The antimicrobial activity of different extracts of Alternanthera caracasana. HBK against 11 bacterial strains and 1 yeast strain was evaluated. The ethyl acetate extract showed antimicrobial activity against Staphylococcus aureus., Staphylococcus epidermidis., Bacillus subtilis., Sarcina lutea., and one strain of Vibrio cholerae.. There was no antimicrobial activity against Candida albicans.. As a bioactive compound, 7-methoxycoumarin was identified.

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Section: Determination Of Mic and Mbcsupporting

confidence: 87%

Antimicrobial Activity of Alternanthera caracasana.

Canales-Martínez

Hernández-Delgado

Flores-Ortíz

et al. 2005

Pharmaceutical Biology

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“…There are types of coumarins found in nature due to various permutations brought about by substitutions and conjugations; however, most of the pharmacological and biochemical studies have been done on coumarin itself and on its primary metabolite, 7-hydroxycoumarin in man [13]. Some of this earlier pharmacological work on coumarin has been reviewed [14], and other more comprehensive reviews [13, 15, 16] deal with the occurrence, chemistry, and biochemical properties of both simple and more complex natural coumarins. …”

Section: Introductionmentioning

confidence: 99%

Review on Natural Coumarin Lead Compounds for Their Pharmacological Activity

Venugopala

Rashmi

Odhav

2013

BioMed Research International

700

474

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Coumarin (2H-1-benzopyran-2-one) is a plant-derived natural product known for its pharmacological properties such as anti-inflammatory, anticoagulant, antibacterial, antifungal, antiviral, anticancer, antihypertensive, antitubercular, anticonvulsant, antiadipogenic, antihyperglycemic, antioxidant, and neuroprotective properties. Dietary exposure to benzopyrones is significant as these compounds are found in vegetables, fruits, seeds, nuts, coffee, tea, and wine. In view of the established low toxicity, relative cheapness, presence in the diet, and occurrence in various herbal remedies of coumarins, it appears prudent to evaluate their properties and applications further.

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“…They are characterized by a variety of oxygenation pat terns on the benzopyrone nucleus (Murray, 1997) and display a remarkable array of biochemical and pharmacological actions (Bourinbaiar et al, 1993;Egan et al, 1990;Galabov et al, 1996;Maucher and von Angerer, 1994;Lee et al, 1994;Paya et al, 1994). We have recently reported on some biological activities of a series of simple coumarins including antimutagenic properties with respect to the mutagenic heterocyclic arom atic amine, 2-amino-3-methylimidazo[4,5-f]quinoline (Edenharder et al, 1995), and cytotoxic effects to human tum our cell lines .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Simple Coumarins: Structural Requirements for Biological Activity

Kayser

Kolodziej

1999

Zeitschrift Für Naturforschung C

128

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The antibacterial activity of a series of simple coumarins was evaluated against 8 microor ganisms, including three Gram-positive (Staphylococcus aureus, beta-hemolytic Streptococcus and Streptococcus pneum oniae) and five Gram-negative bacteria (Escherichia coli, Klebsiella pneum oniae, Pseudom onas aeruginosa, Proteus mirabilis and H aemophilus influenzae), using the microdilution broth method. The coumarins tested showed broad diversity regarding growth inhibitory activity with minimum inhibitory concentrations ranging from 0.9 to >12.4 (j.M . This study, presenting the first systematic analysis of structure-activity relationships among this group of coumarins, revealed some interesting structural requirements. While coumarins with a methoxy function at C-7 and, if present, an OH group at either the C-6 or C-8 position are invariably effective against the spectrum of tested standard bacteria (Gramnegative microorganisms including the Gram-positive bacterium Staphylococcus aureus), the presence of an aromatic dimethoxy arrangement is apparently favourable against those mi croorganisms which require special growth factors (beta-hemolytic Streptococcus, Streptococ cus pneum oniae and Haem ophilus influenzae). A combination of these structural features, two methoxy functions and at least one additional phenolic group as reflected by the highly oxygenated coumarins, identify promising candidates with antibacterial broad-spectrum ac tivity.

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Naturally Occurring Plant Coumarins

Cited by 38 publications

References 212 publications

Antimicrobial Activity of Alternanthera caracasana.

Antimicrobial Activity of Alternanthera caracasana.

Review on Natural Coumarin Lead Compounds for Their Pharmacological Activity

Antibacterial Activity of Simple Coumarins: Structural Requirements for Biological Activity

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