Antimicrobial Activity of <i>Alternanthera caracasana</i>.

Canales-Martínez, María Margarita; Hernández-Delgado, Tzasná; Flores-Ortíz, César Mateo; Durán‐Díaz, Ángel; García-Bores, Ana María; Avila-Acevedo, Guillermo

doi:10.1080/13880200590951685

Cited by 10 publications

(8 citation statements)

References 2 publications

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“…Traditionally, the various plant parts (stems, leaves, flowers, roots) of A. caracasana Kunth have been used to treat dysentery, diarrhea, and fever. The infusion of the plant is used as lavage or beverage in the traditional system of medicines ( Canales-Martínez et al, 2008 ). The aerial parts of A. Brasiliana (L.) Kuntze are indicated in the treatment of inflammation, pain, and various infections ( Hundiwale et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

“…Canales-Martínez and the team had evaluated the antimicrobial effect of the hexane, chloroform, methanolic, acetone, and ethyl acetate extracts obtained from the aerial parts of Alternanthera caracasana Kunth and also isolated a bioactive compound, 7-methoxycoumarin. They observed that the ethyl acetate extract as well as 7-methoxycoumarin were active against various Gram-positive and Gram-negative bacterial strains, but inactive against Candida albicans ( Canales-Martínez et al, 2008 ). Phytochemical profiling of Alternanthera caracasana Kunth is still not done, leaving a scope for the researchers.…”

Section: Introductionmentioning

confidence: 99%

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The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

et al. 2022

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Ethnopharmacological relevance: The genus Alternanthera (Amaranthaceae) comprises 139 species including 14 species used traditionally for the treatment of various ailments such as hypertension, pain, inflammation, diabetes, cancer, microbial and mental disorders.Aim of the review: To search research gaps through critical assessment of pharmacological activities not performed to validate traditional claims of various species of Alternanthera. This review will aid natural product researchers in identifying Alternanthera species with therapeutic potential for future investigation.Materials and methods: Scattered raw data on ethnopharmacological, morphological, phytochemical, pharmacological, toxicological, and clinical studies of various species of the genus Alternanthera have been compiled utilizing search engines like SciFinder, Google Scholar, PubMed, Science Direct, and Open J-Gate for 100 years up to April 2021.Results: Few species of Alternanthera genus have been exhaustively investigated phytochemically, and about 129 chemical constituents related to different classes such as flavonoids, steroids, saponins, alkaloids, triterpenoids, glycosides, and phenolic compounds have been isolated from 9 species. Anticancer, antioxidant, antibacterial, CNS depressive, antidiabetic, analgesic, anti-inflammatory, and immunomodulator effects have been explored in the twelve species of the genus. A toxicity study has been conducted on 3 species and a clinical study on 2 species.Conclusions: The available literature on pharmacological studies of Alternanthera species reveals that few species have been selected based on ethnobotanical surveys for scientific validation of their traditional claims. But most of these studies have been conducted on uncharacterized and non-standardized crude extracts. A roadmap of research needs to be developed for the isolation of new bioactive compounds from Alternanthera species, which can emerge out as clinically potential medicines.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

et al. 2022

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“…Antibacterial potential of crude extracts from numerous plants has been evaluated by agar well assay [21,22] and MIC determined based on which anti-infective lead molecules are isolated for use as a therapeutic agent [23,24]. Antibacterial activity of the alcohol extract of stem bark of Picralima nitida was tested against Staphylococcus aureus ATCC 12600 [25], where crude extract had a MIC range of 25 -50 mg/ml.…”

Section: Discussionmentioning

confidence: 99%

Anti-staphylococcal potential of Callistemon rigidus

Gomber

Saxena

2007

Open Medicine

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AbstractThe last decade witnessed the emergence of Staphylococcus aureus- a versatile human pathogen, as a deadly superbug. The enormous genetic plasticity of the organism assists it to endlessly evolve resistance mechanisms against existing anti-infectives thus necessitating the need to control the spread of resistant staphylococcal isolates in hospitals and health care settings. This in turn demands the incessant exploration of newer biological matrices in search of diverse chemical entities with novel drug targets. Since time immemorial higher plants continue to be the best source of newer compounds with high therapeutic potential. Lead fractions from same or different plants can be developed into effective antibacterial polyherbal formulations. A lead fraction from methanolic extract of leaves of Callistemon rigidus exhibited a dose dependent antistaphylococcal activity during in vitro agar well assay against a panel of twenty seven clinical multidrug resistant S. aureus isolates. Further, minimal inhibitory concentration (MIC) evaluation by in vitro 96-well microplate based assay established a MIC range of 1.25–80 μg/ml as compared to 5–320 μg/ml of positive control, Cefuroxime sodium. The MIC50 and MIC90 of the methanolic lead fraction were 5 μg/ml and 40 μg/ml respectively. The present study thus signifies the vast potential of the lead fraction from Callistemon rigidus for future development into a herbal drug/ formulation and to impede global health crisis due to multidrug resistant Staphylococcus aureus.

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“…A.brasiliana, known as lancetilla, used by the indigenous community of Colombia (Tikuna of the upper Amazon) as an analgesic and to relieve gastrointestinal problems (6). Some species, such as A. caracasana HBK, present antimicrobial activity (7), besides being used to treat different diseases already mentioned (Aguilar, 1994).…”

Section: Introductionmentioning

confidence: 99%

In vitro micropropagation of Alternanthera Ficoidea L. by callus formation on MS medium

2022

pnr

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In this research work, the in vitro propagation of Alternanthera ficoidea, an ornamental plant belonging to the Amaranthaceae family native to South America, was carried out. This plant is considered important due to the presence of important pharmaceutical products such as tannins, saponins, phytols, carotenoids, xanthophylls and polyphenols, which is why it can be included as a medicinal herb as well as being used colloquially as a tranquilizer and as a treatment for gastritis. This method guarantees to obtain a large number of homogeneous explants from the mother plant tissue, taking advantage of the division and regeneration capacity that plant cells possess when they are in adequate conditions for their growth. To achieve this in vitro establishment, three disinfection methods were evaluated, obtaining a greater number of viable explants with the use of 0.1% mercuric chloride for 5 min and greater shoot growth with the combination of phytohormones (1.5 + 1.5 mg.L-1 of AG3 and BAP respectively) reaching an average shoot length of 3.7 cm. These seedlings were acclimatized to nursery conditions.

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Antimicrobial Activity of Alternanthera caracasana.

Cited by 10 publications

References 2 publications

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

Anti-staphylococcal potential of Callistemon rigidus

In vitro micropropagation of Alternanthera Ficoidea L. by callus formation on MS medium

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