Anti-staphylococcal potential of Callistemon rigidus

Gomber, Charu; Saxena, Sanjai

doi:10.2478/s11536-007-0004-8

Cited by 18 publications

(14 citation statements)

References 23 publications

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“…17 MIC is considered to be the gold standard technique to evaluate the susceptibility of a microorganism to a particular antibiotic and performed as reported earlier. 18 Briefly 50 µL of the 18 h old 0.5 McFarland adjusted bacterial suspension in physiological saline was dispensed in each well. 125 µL of MH broth was added in the wells to achieve a final bacterial cell concentration of 10 6 cells in the well.…”

Section: In Vitro Microbroth Dilution Assay To Determine Minimal Inhimentioning

confidence: 99%

Synthesis and Anti-Staphylococcal Activity of 2,4-Disubstituted Diphenylamines

Mehton¹,

Meshram²,

Saxena³

et al. 2016

Journal of the Brazilian Chemical Society

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Infections caused by Staphylococcus aureus are ubiquitous and life threatening. Evolution of resistant strains has necessitated the need to continuously discover new drugs to combat such organisms. Diphenyl ethers, such as triclosan, have recently shown potential as antibacterial agents. In this study, a series of diphenyl amines were synthesized and evaluated for in vitro antibacterial activity against Gram-positive (Staphylococcus aureus, Bacillus subtilis, Staphylococcus epidermidis) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Pseudomonas putida) bacteria. Preliminary results showed that six of the twelve synthesized molecules were active against Staphylococcus aureus. Most notable amongst them were compounds 2(2,4-dinitrophenylamino) phenol and 2(2-dinitrophenylamino)phenol having minimum inhibitory concentration (MIC) in the range of 7.8-15.6 µg mL -1 and 7.8-62.5 µg mL -1 respectively for all the eight selected organisms. Five active compounds from the preliminary results were further screened against resistant S. aureus cultures where compounds 2(2,4-dinitrophenylamino)phenol, 2(2-dinitrophenylamino)phenol and 2-chloro-N-(2-(2,4-dichlorophenylamino)phenyl)acetamide gave encouraging results having MIC in the range 3.9-7.8 µg mL -1 for most of the organisms. Results obtained above for the selected organisms and the resistant S. aureus strains conclude that hydroxyl group at 2-position of ring B potentiates the antibacterial activity and overcomes the antibiotic resistance.

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Section: In Vitro Microbroth Dilution Assay To Determine Minimal Inhimentioning

confidence: 99%

Synthesis and Anti-Staphylococcal Activity of 2,4-Disubstituted Diphenylamines

Mehton¹,

Meshram²,

Saxena³

et al. 2016

Journal of the Brazilian Chemical Society

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“…Extracts of Sutherlandia frutescens, Callistemon rigidus, Shorea hemslyana, Garcinia spp., Terminalia avicinnoides, and Ocimum gratissisimum have exhibited potential anti-MRSA activity and are thus candidates for exploration of bioactive compounds to overcome resistance in S. aureus [132][133][134][135]. Some lead compounds from plant extracts have already been isolated and tested for their potential for development of anti-MRSA drugs.…”

Section: New Chemical Templatesmentioning

confidence: 99%

Surmounting antimicrobial resistance in the Millennium Superbug: Staphylococcus aureus

Saxena

Gomber

2010

Open Medicine

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AbstractStaphylococcus aureus is the third most dreaded pathogen posing a severe threat due to its refractory behavior against the current armamentarium of antimicrobial drugs. This is attributed to the evolution of an array of resistance mechanisms responsible for morbidity and mortality globally. Local and international travel has resulted in the movement of drug resistant S. aureus clones from hospitals into communities and further into different geographical areas where they have been responsible for epidemic outbreaks. Thus, there is a dire necessity to refrain further cross movement of these multidrug resistant clones across the globe. The plausible alternative to prevent this situation is by thorough implementation of regulatory aspects of sanitation, formulary usage and development of new therapeutic interventions. Various strategies like exploring novel antibacterial targets, high throughput screening of microbes, combinatorial and synthetic chemistry, combinatorial biosynthesis and vaccine development are being extensively sought to overcome multidrug resistant chronic Staphylococcal infections. The majority of the antibacterial drugs are of microbial origin and are prone to being resisted. Anti-staphylococcal plant natural products that may provide a new alternative to overcome the refractory S.aureus under clinical settings have grossly been unnoticed. The present communication highlights the new chemical entities and therapeutic modalities that are entering the pharmaceutical market or are in the late stages of clinical evaluation to overcome multidrug resistant Staphylococcal infections. The review also explores the possibility of immunity and enzyme-based interventions as new therapeutic modalities and highlights the regulatory concerns on the prescription, usage and formulary development in the developed and developing world to keep the new chemical entities and therapeutic modalities viable to overcome antimicrobial resistance in S. aureus.

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“…Callistemon spp., a genus of Myrtaceae from Australia, are widely used as ornamental plants and are known as remedies in folklore medicine (Saxena and Gomber 2006;Gomber and Saxena 2007;Oyedeji et al 2009). Recently, several biocidal properties have been described in plants belonging to this genus including antimicrobial and antibacterial properties (Anudwipa et al 2009;Seyydnejad et al 2010;Silva et al 2010), and insecticidal and sterilizing properties towards insects associated with stored food (Shukla et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Volatile organic compounds emitted by bottlebrush species affect the behaviour of the sweet potato whitefly

Sacchetti

Rossi

Bellini

et al. 2015

Arthropod-Plant Interactions

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The behavioural response of the sweet potato whitefly, Bemisia tabaci biotype B, to the volatiles emitted by three different species of Callistemon (C. laevis, C. pallidus and C. phoeniceus) was assayed in still-air, and Y-tube olfactometers. B. tabaci adults showed a preference for C. pallidus, while C. laevis and C. phoeniceus were less attractive to the insects when compared to a blank control or to C. pallidus. Volatile organic compounds emitted by the leaves of the three Callistemon species were analysed by solid phase microextraction coupled with GC–MS. 1,8-Cineole was detected in high percentages in C. phoeniceus and C. laevis headspaces, while linalool was abundant in the headspace of C. pallidus. Because of this difference, behavioural tests in the Y-tube olfactometer were carried out also with 1,8-cineole and linalool. Adults of B. tabaci were attracted by linalool, while they were repelled by 1,8-cineole compared with pure air or linalool. These results support the role of these volatiles in the host plant selection process by a herbivorous insect and lay the foundations for the development of sustainable control strategies based on the manipulation of insect pest behaviou

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Anti-staphylococcal potential of Callistemon rigidus

Cited by 18 publications

References 23 publications

Synthesis and Anti-Staphylococcal Activity of 2,4-Disubstituted Diphenylamines

Synthesis and Anti-Staphylococcal Activity of 2,4-Disubstituted Diphenylamines

Surmounting antimicrobial resistance in the Millennium Superbug: Staphylococcus aureus

Volatile organic compounds emitted by bottlebrush species affect the behaviour of the sweet potato whitefly

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