The antimicrobial activity of different extracts of Alternanthera caracasana. HBK against 11 bacterial strains and 1 yeast strain was evaluated. The ethyl acetate extract showed antimicrobial activity against Staphylococcus aureus., Staphylococcus epidermidis., Bacillus subtilis., Sarcina lutea., and one strain of Vibrio cholerae.. There was no antimicrobial activity against Candida albicans.. As a bioactive compound, 7-methoxycoumarin was identified.
Significance and Impact of the Study: To contribute to fighting antimicrobial resistance to antibiotics, we evaluated an essential oil (EO) of Tagetes lucida and the mixture of its main compounds (PREO) against multi-drug resistant bacteria. The EO and the PREO have antibacterial activity and modulate antibiotic resistance in Staphylococcus aureus and Pseudomonas aeruginosa. Also, we overcame the natural unpredictability of the EOs activity by determining which EO components inhibited bacteria and then producing a consistent PREO with predictable antibacterial and modulatory antibiotic resistance activity. To our knowledge, this is the first time that this procedure has generated a reconstituted blend with predictable effects from EOs.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.