Naturally derived anti-inflammatory compounds from Chinese medicinal plants

Pharmacologically active constituents from traditional medicinal plants have received great attention as sources of novel agents, pharmaceutical intermediates, and chemical entities for synthetic or semisynthetic drugs due to their potent pharmacological activities, low toxicity, and economic viability. Numerous components have been isolated from traditional medicinal plants, including alkaloids, flavonoids, and terpenoids, and clinical and experimental studies suggested that these components have useful pharmacological properties such as antiinfectious, antioxidative, and antiinflammatory effects. In this review, modern ethnobotanical approaches to explore folk medicinal plants as candidates for drug discovery with the greatest possibility of success are discussed. Determining the bioactive mechanisms and tracing structure-activity relationships will promote the discovery of new drugs and pharmacological agents.

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“…20,38,[44][45][46] The most important basic effects are antiinfectious, antioxidant, and antiinflammatory.…”

Section: Major Pharmacological Activitiesmentioning

confidence: 99%

Prospecting for Bioactive Constituents from Traditional Medicinal Plants through Ethnobotanical Approaches

Wang

Long

et al. 2014

Biological & Pharmaceutical Bulletin

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“…Several bioactive compounds from plants (Wang et al, 2013c), rhizomes (Debnath et al, 2013) and marine algae (Kim et al, 2014) have been isolated and their anti-inflammatory effect studied by various mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq

Martins

Barreiro

et al. 2016

Trends in Food Science & Technology

105

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Background: In the recent years natural resources are being in focus due to their great potential to be exploited in the discovery/development of novel bioactive compounds and, among them, mushrooms can be highlighted as alternative sources of anti-inflammatory agents. Scope and approach:The present review reports the anti-inflammatory activity of mushroom extracts and of their bioactive metabolites involved in this bioactive action.Additionally the most common assays used to evaluate mushrooms anti-inflammatory activity were also reviewed, including in vitro studies in cell lines, as well as in animal models in vivo. Key findings and conclusions:The anti-inflammatory compounds identified in mushrooms include polysaccharides, terpenes, phenolic acids, steroids, fatty acids and other metabolites.Among them, polysaccharides, terpenoids and phenolic compounds seem to be the most important contributors to the anti-inflammatory activity of mushrooms as demonstrated by numerous studies. However, clinical trials need to be conducted in order to confirm the effectiveness of some of these mushroom compounds namely, inhibitors of NF-κB pathway and of cyclooxygenase related with the expression of many inflammatory mediators.

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“…These enzymes also play an important role in inflammation, since they are involved in the biosynthesis of inflammatory lipid mediators, such as leukotrienes and prostagladins, and their inhibition is considered as one of the targets for the prevention of diseases, whose development is linked to oxidative stress and inflammation (Radmark and Samuelsson, 2007). Chronic inflammation in the brain is a pathological feature of Alzheimer's disease (AD) and in this process, large amounts of pro-inflammatory substances such as nitric oxide (NO) are produced (Wang et al, 2013). Therefore, the use of antioxidant substances that scavenge and eradicate ROS may prevent or minimize these oxidation-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory, anticholinesterase and antioxidant activity of leaf extracts of twelve plants used traditionally to alleviate pain and inflammation in South Africa

Dzoyem¹,

Eloff²

2015

Journal of Ethnopharmacology

137

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Ethnopharmacological relevanceOxidative stress and inflammatory conditions are among the pathological features associated with the central nervous system in Alzheimer's disease. Traditionally, medicinal plants have been used to alleviate inflammation, pains and also other symptoms possibly associated with Alzheimer's disease. Therefore, the present study was designed to determine the in vitro antiinflammatory, antioxidant and anticholinesterase activity of twelve South African medicinal plants traditionally used to alleviate pain and inflammation. Materials and MethodsNitric oxide (NO) production in LPS-activated RAW 264.7 macrophages and 15-lipoxygenase (LOX) inhibitory assay were used to evaluate the anti-inflammatory activity.Acetylcholinesterase inhibition was assessed by using a modification of the Ellman's method.Antioxidant activity, total phenolic and total flavonoids contents were determined using standard in vitro methods. ResultsThe extract of Burkea africana had the highest anti-15-lipoxygenase activity with 85.92% inhibition at 100 µg/mL. All the extracts tested inhibited nitric oxide (NO) production in a dose dependant manner in LPS-stimulated RAW 264.7 macrophages. However, extracts from Leucaena leucocephala, Lippia javanica inhibited the production of NO by 97% at a concentration of 25 µg/mL. In addition, both Leucaena leucocephala and Englerophytum magaliesmontanum had strong activity against acetylcholinesterase with IC 50 values of 118 µg/mL and 160 µg/mL respectively. Hight levels of phenolics and flavonoids were found in Leucaena leucocephala, Lippia javanica and Burkea africana. The correlation with antioxidant activities was not strong indicating that other metabolites may also be involved in antioxidant activity. ConclusionsThe results obtained in this study validate the use of leaf extracts of these plants in South African traditional medicine against inflammation. Extracts of these plants species might be of value in the management of various diseases emerging from oxidative stress and related degenerative disorders.2

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Naturally derived anti-inflammatory compounds from Chinese medicinal plants

Cited by 206 publications

References 237 publications

Prospecting for Bioactive Constituents from Traditional Medicinal Plants through Ethnobotanical Approaches

Prospecting for Bioactive Constituents from Traditional Medicinal Plants through Ethnobotanical Approaches

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Anti-inflammatory, anticholinesterase and antioxidant activity of leaf extracts of twelve plants used traditionally to alleviate pain and inflammation in South Africa

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