Natural products' role against COVID-19

Abstract

Natural products can play an important role in COVID-19 chemotherapy development.

Computational guided identification of a citrus flavonoid as potential inhibitor of SARS-CoV-2 main protease

“…With 668,910 global mortality till date (6th August 2020), and with no effective treatment available, the quest for discovering a drug or vaccine against SARS-CoV-2 has accelerated [1]. In this crisis, a renewed interest in traditional phytomedicinal plants or natural compounds has garnered significant attention due to its medicinal properties, low toxicity and adverse effects [2,3]. At present, antagonistic approach by blocking the integral replication system of SARS-CoV-2 is being considered as one of the effective antiviral therapeutic strategies.…”

“…Considering the urgent need for an effective therapeutic agent for SARS-CoV-2 virus, several researchers have emphasized the importance of natural compounds [2,3,6]. Natural plant products have been used for generations in Traditional Chinese as well as Indian Ayurvedic Medicines as antiviral treatments.…”

The race to treat COVID-19: Potential therapeutic agents for the prevention and treatment of SARS-CoV-2

“…In the last few months, the race to discover novel treatments for COVID -19 has immensely accelerated, and numerous peptides and small molecules have been recognized as encouraging therapeutic agents against SARS-CoV-2 [ [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] ]. Recently, the constrained peptides have received much attention in the area of drug development; however, a certain inherent admonition limits its use as a drug [ [46] , [47] , [48] ].…”

Development of nanoparticle-delivery systems for antiviral agents: A review

“…Antiviral drugs based on natural compounds have attracted considerable attention from researchers because of their low toxicity, low cost, low side effects, and reduced likelihood of promoting antiviral resistance [ 8 ]. Several bioactive compounds have been found to have activity against viruses, including flavonoids, terpenoids, limonoids, organosulfur compounds, sulfides, polyphenolics, lignans, saponins, coumarins, chlorophyllins, alkaloids, furyl compounds, thiophenes, polyines, proteins, and peptides [ 130 ].…”