Development of nanoparticle-delivery systems for antiviral agents: A review

Delshadi, Rana; Bahrami, Arash; McClements, David Julian; Moore, Matthew D.; Williams, Leonard

doi:10.1016/j.jconrel.2021.01.017

Cited by 67 publications

(32 citation statements)

References 172 publications

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Section: Resultsmentioning

confidence: 99%

“…However, ZnO loaded nanofibers were the most potent antiviral agent (Figure 3). The aforementioned activity could be explained by the inorganic metallic substances being able to extract the hydrogen atom in the viral proteins, which leads to viral rupture or morphology changes [27]. Imai et al studied the impact of copper ion-exchanged zeolites on the inactivation of avian influenza viruses (AIVs) on cotton textiles and found that both highly pathogenic H5N1 and low pathogenic H5N3 viruses were inactivated on the copper ion-exchanged zeolite textile materials, even after short incubations [28].…”

Section: Antiviral Activitymentioning

confidence: 99%

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Biodegradable Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19 and Anti-Multidrug Resistant Bacteria Evaluation

et al. 2021

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Biodegradable nanofibrous hybrid membranes of polyvinyl alcohol (PVA) with ZnO and CuO nanoparticles were manufactured and characterized, and their anti-COVID-19 and anti-multidrug resistant bacteria activities were also evaluated. The morphological structures of the prepared PVA composites nanofibers were observed by scanning electron microscope (SEM), which revealed a homogenous pattern of the developed nanofibers, with an average fibrous diameter of 200–250 nm. Moreover, the results of the SEM showed that the fiber size changed with the type and the concentration of the metal oxide. Moreover, the antiviral and antibacterial potential capabilities of the developed nanofibrous membranes were tested in blocking the viral fusion of SARS-COV-2, as a representative activity for COVID-19 deactivation, as well as for their activity against a variety of bacterial strains, including multi-drug resistant bacteria (MDR). The results revealed that ZnO loaded nanofibers were more potent antiviral agents than their CuO analogues. This antiviral action was attributed to the fact that inorganic metallic compounds have the ability to extract hydrogen bonds with viral proteins, causing viral rupture or morphological changes. On the other hand, the anti-multi-drug resistant activity of the prepared nanofibers was also evaluated using two techniques; the standard test method for determining the antimicrobial activity of immobilized antimicrobial agents under dynamic contact conditions and the standard test method for determining the activity of incorporated antimicrobial agents in polymeric or hydrophobic materials. Both techniques proved the superiority of the ZnO loaded nanofibers over the CuO loaded fibers. The results of the antiviral and antibacterial tests showed the effectiveness of such nanofibrous formulas, not only for medical applications, but also for the production of personal protection equipment, such as gowns and textiles.

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Section: Resultsmentioning

confidence: 99%

Section: Antiviral Activitymentioning

confidence: 99%

Biodegradable Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19 and Anti-Multidrug Resistant Bacteria Evaluation

et al. 2021

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“…If nanoformulations are attached with the target ligand on their surface, the targeted drug delivery can be achieved avoiding the negative consequences [ 95 ]. Several polymers including poly(lactic-co-glycolic acid) (PLGA), polyvinyl alcohol(PVA), poly lactic acid (PLA), polyethylene glycol (PEG), hyaluronate, alginic acid and collagen have been approved by FDA for drug delivery [ 96 ]. Recently, a company named ‘Bioavanta-Bosti’, Switzerland has announced nanoformulation named Novochizol™ which is a chitosan nanoparticle aerosol formulation which can be used for targeted delivery of anti-SARS-CoV-2 therapeutics to the lungs of the patients [ 97 ].…”

Section: Nanoparticles Against Sars-cov-2: Therapeutic and Vaccine Developmentmentioning

confidence: 99%

Nano-engineered tools in the diagnosis, therapeutics, prevention, and mitigation of SARS-CoV-2

Kamat

Kumari

Jayabaskaran

2021

Journal of Controlled Release

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The recent outbreak of SARS-CoV-2 has forever altered mankind resulting in the COVID-19 pandemic. This respiratory virus further manifests into vital organ damage. Nanotechnology has been moonlighting in the scientific community to combat several severe diseases. This review highlights the triune of the nano-toolbox in the areas of diagnostics, therapeutics, prevention, and mitigation of SARS-CoV-2. Nanogold test kits have already been on the frontline of rapid detection. Breath tests, magnetic nanoparticle-based nucleic acid detectors, and the use of Raman Spectroscopy present myriads of possibilities in developing point of care biosensors. This will ensure sensitive, affordable, and accessiblemass surveillance. Most of the therapeutics are trying to focus on blocking the viral entry into the cell and fighting with cytokine storm. Nanobodies as vaccines against S and N protein have regained importance. All the vaccines coming with promising phase 3 clinical trials have used nano-delivery systems for delivery of vaccine-cargo. The use of chemically diverse metal, carbon and polymeric nanoparticles, nanocages and nanobubbles demonstrate opportunities to develop anti-viral nanomedicine. Nanotechnology also presents myriads of options for targeted drug delivery. In order to prevent and mitigate the viral spread, high-performance charged nanofiber filters, spray coating of nanomaterials on surfaces, novel materials for PPE kits and facemasks have been developed that accomplish over 90% capture of airborne SARS-CoV-2. Nano polymer-based disinfectants are being tested to make smart-transport for human activities. Despite the promises of this toolbox, challenges in terms of reproducibility, specificity, and efficacy are yet to overcome.

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“…Because of their nanoscale dimensions and adjustable surface properties, lipid-based nanocarriers are frequently advantageous for delivering antivirals to affected areas [ 67 ]. Several earlier studies have proven the potential of lipid-based nanocarriers to encapsulate and transport ARV.…”

Section: Lipid-based Nanocarriers For Delivery Of Arv Agentsmentioning

confidence: 99%

Lipid Nanocarriers for Anti-HIV Therapeutics: A Focus on Physicochemical Properties and Biotechnological Advances

et al. 2021

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Since HIV was first identified, and in a relatively short period of time, AIDS has become one of the most devastating infectious diseases of the 21st century. Classical antiretroviral therapies were a major step forward in disease treatment options, significantly improving the survival rates of HIV-infected individuals. Even though these therapies have greatly improved HIV clinical outcomes, antiretrovirals (ARV) feature biopharmaceutic and pharmacokinetic problems such as poor aqueous solubility, short half-life, and poor penetration into HIV reservoir sites, which contribute to the suboptimal efficacy of these regimens. To overcome some of these issues, novel nanotechnology-based strategies for ARV delivery towards HIV viral reservoirs have been proposed. The current review is focused on the benefits of using lipid-based nanocarriers for tuning the physicochemical properties of ARV to overcome biological barriers upon administration. Furthermore, a correlation between these properties and the potential therapeutic outcomes has been established. Biotechnological advancements using lipid nanocarriers for RNA interference (RNAi) delivery for the treatment of HIV infections were also discussed.

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Development of nanoparticle-delivery systems for antiviral agents: A review

Cited by 67 publications

References 172 publications

Biodegradable Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19 and Anti-Multidrug Resistant Bacteria Evaluation

Biodegradable Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19 and Anti-Multidrug Resistant Bacteria Evaluation

Nano-engineered tools in the diagnosis, therapeutics, prevention, and mitigation of SARS-CoV-2

Lipid Nanocarriers for Anti-HIV Therapeutics: A Focus on Physicochemical Properties and Biotechnological Advances

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