“…Based on the variety of research that has been carried out in drug discovery and medicinal chemistry, it is a well-known reality that nature, including plants, animals, marine organisms and microorganisms, remains the richest, most varied and sustainable source of structurally diverse compounds with critical biological activity. 1,2 The ent-kaurane tetracyclic diterpenes represent a large group of natural products widely found in different plant families and endowed with remarkable biological activities. 3 Structurally, the majority of ent-kauranes discovered so far have a tetracyclic core structure formed by combining a perhydrophenanthrene skeleton with a cyclopentane ring.…”