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2000 carboxylic amides carboxylic amides (benzene compounds) Q 0490 30 -077 Synthesis and Analgesic Activity of Novel N-Acylarylhydrazones and Isosters, Derived from Natural Safrole. -Starting from safrole (I) new compounds of type (VII) and (VIII) are formed. Derivative (VII) is formed as a mixture of E/Z isomers and found to be the most potent antiinflammatory and analgesic agent within this study. A similar compound without ethylene bridge (VIII) is preferentially formed in (E)-form because of steric hindrance of the second aryl group. -(LIMA, PATRICIA C.; LIMA, LIDIA M.; DA SILVA, KELLI CRISTINE M.; LEDA, PAULO HENRIQUE O.; DE MIRANDA, ANA LUISA P.; FRAGA, CARLOS A. M.; BARREIRO, ELIEZER J.; Eur.

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