Natural Polysaccharides as Pharmaceutical Excipients

Yılmaz, Nazire Deniz; Çılgı, Gülbanu Koyundereli; Yılmaz, Kenan

doi:10.1002/9781119041450.ch14

Cited by 19 publications

(10 citation statements)

References 79 publications

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“…First, the electron-transporting property of the ZnO and the ZnO@APTMS films was studied through space-charge-limited current (SCLC) measurements using an electron-only device with a structure of ITO/Al/ZnO (ZnO@APTMS)/Al. As shown by Figure (c), these two J–V curves were fit well by the SCLC mode with a typical ohmic contact region and a SCLC region, and the trapped space charge region was absent due to the trap-free space-charge-limited current behavior of these electron-only devices . Thus, the corresponding electron mobilities of the ZnO and ZnO@APTMS films could be calculated from the SCLC region according to the Mott–Gurney SCLC equation: where ε r , ε 0 , μ e , and d are the relative dielectric constant of the materials, the vacuum dielectric constant, the electron mobility, and the film thickness, respectively.…”

Section: Results and Discussionmentioning

confidence: 72%

Silane-Capped ZnO Nanoparticles for Use as the Electron Transport Layer in Inverted Organic Solar Cells

et al. 2018

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Zinc oxide (ZnO) nanoparticles are widely used as electron- transport layer (ETL) materials in organic solar cells and are considered to be the candidate with the most potential for ETLs in roll-to-roll (R2R)-printed photovoltaics. However, the tendency of the nanoparticles to aggregate reduces the stability of the metal oxide inks and creates many surface defects, which is a major barrier to its printing application. With the aim of improving the stability of metal oxide nanoparticle dispersions and suppressing the formation of surface defects, we prepared 3-aminopropyltrimethoxysilane (APTMS)-capped ZnO (ZnO@APTMS) nanoparticles through surface ligand exchange. The ZnO@APTMS nanoparticles exhibited excellent dispersibility in ethanol, an environmentally friendly solvent, and remained stable in air for at least one year without any aggregation. The capping of the ZnO nanoparticles with APTMS also reduced the number of surface-adsorbed oxygen defects, improved the charge transfer efficiency, and suppressed the light-soaking effect. The thickness of the ZnO@APTMS ETL could reach 100 nm without an obvious decrease in the performance. Large-area APTMS-modified ZnO films were successfully fabricated through roll-to-roll microgravure printing and exhibited good performance in flexible organic solar cells. This work demonstrated the distinct advantages of this ZnO@APTMS ETL as a potential buffer layer for printed organic electronics.

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Section: Results and Discussionmentioning

confidence: 72%

Silane-Capped ZnO Nanoparticles for Use as the Electron Transport Layer in Inverted Organic Solar Cells

et al. 2018

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“…The term "Middle lamella" is considered for the region at the interface of two cells. Technical fibres or single fibres are the common terminologies used for the bundles of elementary fibres (27) . From Figure 5, it is observed that the overlapping of the cells appears in a longitudinal view of the fibres.…”

Section: Analysis Of Linear Densitymentioning

confidence: 99%

“…In the outer portion of the bundle, some fibre pull-out is detected whilst at the centre pull-out is https://www.indjst.org/ not visible that much which directs the presence of adequate binding material (commonly lignin). Additionally, all fibre cells have not fractured at the equal stress level probably due to cell wall defects existing along the fibre length which can generate stress intensities leading to ultimate failure (27) . The SEM images of okra fibres are very much similar to the SEM images of other bast fibres.…”

Section: Sem Analysismentioning

confidence: 99%

A comprehensive study on Physico-Mechanical characteristics of Okra fibre (Abelmoschus esculentus) for textile applications

Hossen¹,

Islam²,

Mahee³

et al. 2021

IJST

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“…In solid dosage forms they have been employed as excipients in the delivery systems with a modified release. With these oral systems, a targeted release of the active ingredient in the distal segment of the gastrointestinal tract can be achieved [1][2][3][4][5][6]. One of these polysaccharides is chitosan, whose safety, nontoxicity, biocompatibility, and biodegradability predetermine it for biomedical applications [7].…”

Section: Introductionmentioning

confidence: 99%

A Study of Compressibility, Compactability and Mucoadhesivity of Tableting Materials for Matrix Systems Based on Chitosan

Mužíková

Snejdrova

Martiska³

et al. 2021

Polymers

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The objective of the present research is to evaluate directly compressible chitosan-based tableting materials for the formulation of mucoadhesive matrix tablets intended for targeted drug release to distal segments of the GIT. The influence of sodium alginate, hypromellose, and silicified microcrystalline cellulose (P90) on compressibility, compactability and lubricant sensitivity ratio was tested. Furthermore, the rheological properties of the hydrated surface layer of the matrix tablets and the mucoadhesion to a mucin substrate were analysed. Compressibility was evaluated using the energy profile of the compression process, compactability by means of the tensile strength of tablets, and lubricant sensitivity ratio was calculated to assess the sensitivity to lubricant. Addition of P90 to chitosan improved compressibility, which is demonstrated by the increase in the energy of plastic deformation and the higher tensile strength of tablets. P90 also significantly reduced the high lubricant sensitivity of chitosan. Presence of retarding components led to a decrease in Emax. All tested matrix tablets revealed a good mucoadhesion without a negative effect of P90 content. The viscosity of a gel layer on the surface of matrix tablets containing hypromellose was higher compared to those with sodium alginate. This was not reflected in the adhesive strength of the tablets. The formulated tableting materials combining chitosan and P90 are a suitable matrix for incorporation of an active ingredient, whose delayed release in the intestine can be achieved by the functionality of the chitosan-sodium alginate complex.

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Natural Polysaccharides as Pharmaceutical Excipients

Cited by 19 publications

References 79 publications

Silane-Capped ZnO Nanoparticles for Use as the Electron Transport Layer in Inverted Organic Solar Cells

Silane-Capped ZnO Nanoparticles for Use as the Electron Transport Layer in Inverted Organic Solar Cells

A comprehensive study on Physico-Mechanical characteristics of Okra fibre (Abelmoschus esculentus) for textile applications

A Study of Compressibility, Compactability and Mucoadhesivity of Tableting Materials for Matrix Systems Based on Chitosan

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