Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans

Su, Shan; Wink, Michael

doi:10.1016/j.phytochem.2015.06.021

Cited by 73 publications

(65 citation statements)

References 46 publications

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“…The decrease in ROS ranged between 36-16% in crude extracts and 27-17% in digested samples, thus samples before and after digestion effectively reduced endogenous ROS levels. Similar ROS-scavenging activity has been observed for other antioxidants, such as guarana extract (reduction about 30%) (Peixoto et al, 2017), lignans from Arctium lappa (reduction up to 21%) (Su & Wink, 2015), and grape pomace (reduction of 29-18%) (Jara-Palacios et al, 2013).…”

Section: In Vivo Antioxidant Activity (C Elegans)supporting

confidence: 63%

Bioaccessibility and biological activity of Melissa officinalis , Lavandula latifolia and Origanum vulgare extracts: Influence of an in vitro gastrointestinal digestion

Gayoso¹,

Roxo

Cavero³

et al. 2018

Journal of Functional Foods

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Melissa officinalis, Lavandula latifolia and Origanum vulgare are widely used medicinal plants and spices. Their extracts were evaluated as potential antioxidants for functional food formulations. After being submitted to an in vitro gastrointestinal digestion, all the extracts showed antioxidant activity (measured by DPPH, ABTS, FRAP, TPC). Furthermore, their main polyphenols maintained high stability. Biological activity was measured using Caenorhabditis elegans, which is a widely used model in this context. Treatments of 50 and 100 µg/mL of M. officinalis significantly attenuated juglone-induced stress in the survival assay performed; moreover, all tested concentrations decreased intracellular ROS. Lavandula latifolia and O. vulgare had no significant effect against acute stress in the survival assay, but significantly decreased ROS basal levels. GST-4 expression under juglone-induced oxidative stress was significantly down-regulated by treatment with the three plant extracts (up to 63%). Besides, similar biological activity of all digested extracts was demonstrated in all in vivo assays.

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Section: In Vivo Antioxidant Activity (C Elegans)supporting

confidence: 63%

Bioaccessibility and biological activity of Melissa officinalis , Lavandula latifolia and Origanum vulgare extracts: Influence of an in vitro gastrointestinal digestion

Gayoso¹,

Roxo

Cavero³

et al. 2018

Journal of Functional Foods

Self Cite

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“…The decrease in the MDA content along with restoration of GSH and activities of SOD and GSH-Px by arctigenin is linked with its free radical scavenging and antioxidant activity, consistent with the reports in the literature. [44][45][46] This result may be due to the existence of a phenolic hydroxyl group and three methoxyls in the structure of the arctigenin, and the methoxyl group has taken off the methyl group in the animal, resulting in more phenolic hydroxyl group, which are reductive. In addition to oxidative stress, the activation of microglia in the brain is common and an early event in the onset of neurodegeneration contributing to several neuropathologies.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of arctigenin against neuroinflammation and oxidative stress induced by rotenone

et al. 2018

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“…An efficient in vivo model to study the effect of antioxidants against oxidative stress and aging is the model system Caenorhabditis elegans . For several herbal drugs and isolated polyphenols and terpenoids substantial antioxidant and antiaging effects have been recorded [88,89,90,91,92,93,94]. …”

Section: General Modes Of Action Of Secondary Metabolitesmentioning

confidence: 99%

Modes of Action of Herbal Medicines and Plant Secondary Metabolites

2015

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Plants produce a wide diversity of secondary metabolites (SM) which serve them as defense compounds against herbivores, and other plants and microbes, but also as signal compounds. In general, SM exhibit a wide array of biological and pharmacological properties. Because of this, some plants or products isolated from them have been and are still used to treat infections, health disorders or diseases. This review provides evidence that many SM have a broad spectrum of bioactivities. They often interact with the main targets in cells, such as proteins, biomembranes or nucleic acids. Whereas some SM appear to have been optimized on a few molecular targets, such as alkaloids on receptors of neurotransmitters, others (such as phenolics and terpenoids) are less specific and attack a multitude of proteins by building hydrogen, hydrophobic and ionic bonds, thus modulating their 3D structures and in consequence their bioactivities. The main modes of action are described for the major groups of common plant secondary metabolites. The multitarget activities of many SM can explain the medical application of complex extracts from medicinal plants for more health disorders which involve several targets. Herbal medicine is not a placebo medicine but a rational medicine, and for several of them clinical trials have shown efficacy.

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Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans

Cited by 73 publications

References 46 publications

Bioaccessibility and biological activity of Melissa officinalis , Lavandula latifolia and Origanum vulgare extracts: Influence of an in vitro gastrointestinal digestion

Bioaccessibility and biological activity of Melissa officinalis , Lavandula latifolia and Origanum vulgare extracts: Influence of an in vitro gastrointestinal digestion

Neuroprotective effect of arctigenin against neuroinflammation and oxidative stress induced by rotenone

Modes of Action of Herbal Medicines and Plant Secondary Metabolites

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