Natural human humoral response to salivary gland proteins of Anopheles mosquitoes in Thailand

Waitayakul, Amornrat; Somsri, Sangdao; Sattabongkot, Jetsumon; Looareesuwan, Sornchai; Cui, Liwang; Udomsangpetch, Rachanee

doi:10.1016/j.actatropica.2006.02.004

Cited by 77 publications

(86 citation statements)

References 39 publications

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“…A person who is often exposed to mosquito bite will have higher anti salivary protein IgG level than a person who is rarely exposed to mosquito bite. The result of this research was consistent with the previous research, stating that people living in malaria endemic area who were often exposed to anopheles saliva would express higher immunity level by producing antibody in the form of anti salivary protein IgG (Waitayakul et al 2006). The data from questionnaire states that volunteers younger than 10 years old spent most of their night at home.…”

Section: Salivary Gland and Salivary Gland Proteinsupporting

confidence: 81%

Analysis of Human Immune Response against Salivary Glands Protein Extract of Anopheles sundaicus. L in Malaria Endemic Area

Nuryady

Utomo²,

Armiyanti³

et al. 2017

Microbiol Indones

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Section: Salivary Gland and Salivary Gland Proteinsupporting

confidence: 81%

Analysis of Human Immune Response against Salivary Glands Protein Extract of Anopheles sundaicus. L in Malaria Endemic Area

Nuryady

Utomo²,

Armiyanti³

et al. 2017

Microbiol Indones

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“…19 Saliva contains physiologically active chemicals able to induce humoral immune responses that can be measured. 20 Previous studies have shown that antibodies against vector salivary proteins can serve as markers for disease risk [21][22][23] and can be used to evaluate the efficacy of vector control efforts. 24,25 Our previous studies have shown increased antibody titers to salivary proteins in subjects with malaria or dengue, compared with subjects living in the same region but with no sign of infection.…”

Section: Introductionmentioning

confidence: 99%

Long-Lasting Permethrin-Impregnated Clothing Protects Against Mosquito Bites in Outdoor Workers

Londoño-Rentería

Patel

Vaughn

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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Abstract. Outdoor exposure to mosquitoes is a risk factor for many diseases, including malaria and dengue. We have previously shown that long-lasting permethrin-impregnated clothing protects against tick and chigger bites in a double-blind randomized controlled trial in North Carolina outdoor workers. Here, we evaluated whether this clothing is protective against mosquito bites by measuring changes in antibody titers to mosquito salivary gland extracts. On average, there was a 10-fold increase in titer during the spring and summer when mosquito exposure was likely to be the highest. During the first year of the study, the increase in titer in subjects wearing treated uniforms was 2-to 2.5-fold lower than that of control subjects. This finding suggests that long-lasting permethrin-impregnated clothing provided protection against mosquito bites.

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“…Previous studies have shown that the type and concentration of antibodies against vector salivary gland extract (SGE) can serve as markers for disease transmission and risk (7)(8)(9)(10) and to evaluate the efficacy of vector control efforts (11,12). Additionally, estimating the prevalence of antibodies against all DENV serotypes that have circulated in a specific area gives insight of the population exposure to the virus (13).…”

mentioning

confidence: 99%

Concentración de los anticuerpos en contra de proteínas de las glándulas salivares de Aedes aegypti e historia de la exposición al virus del dengue en residentes de una zona endémica colombiana

Londoño-Rentería

Cardenas²,

Giovanni

et al. 2015

biomedica

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Introduction:Mosquito salivary proteins are able to induce an antibody response that reflects the level of human-vector contact. IgG antibodies against dengue virus (DENV-IgG) are indicators of previous exposure. The risk of DENV transmission is not only associated to mosquito or dengue factors, but also to socioeconomic factors that may play an important role in the disease epidemiology. Objective: To determine the effect of the presence of Aedes aegypti mosquitos in different stages in households and the history of dengue exposure on vector-human contact determined by the level of anti-salivary protein antibodies in people living in a Colombian endemic area. Materials and methods: A pilot study of 58 households and 55 human subjects was conducted in Norte de Santander, Colombia. A questionnaire for socioeconomic factors was administered and houses were examined for the presence of Ae. aegypti specimens in the aquatic stages. The level of DENVIgG antibodies (DENV-IgG), in addition to IgG and IgM anti-Ae. aegypti salivary gland extract (SGE) antibodies (SGE-IgG, SGE-IgM) were evaluated by ELISA using blood collected in filter paper. Results: We found a significant higher level of SGE-IgG antibodies in subjects living in houses with Ae. aegypti in aquatic stages. We also found a higher concentration of SGE-IgG antibodies in people exposed to DENV, a positive correlation between IgM-SGE and IgG-DENV and a negative correlation with IgG-SGE. Conclusion: Anti-salivary proteins antibodies are consistent with the presence of Ae. aegypti aquatic stages inside houses and DENV-IgG antibodies concentrations.

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Natural human humoral response to salivary gland proteins of Anopheles mosquitoes in Thailand

Cited by 77 publications

References 39 publications

Analysis of Human Immune Response against Salivary Glands Protein Extract of Anopheles sundaicus. L in Malaria Endemic Area

Analysis of Human Immune Response against Salivary Glands Protein Extract of Anopheles sundaicus. L in Malaria Endemic Area

Long-Lasting Permethrin-Impregnated Clothing Protects Against Mosquito Bites in Outdoor Workers

Concentración de los anticuerpos en contra de proteínas de las glándulas salivares de Aedes aegypti e historia de la exposición al virus del dengue en residentes de una zona endémica colombiana

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