Natural and synthetic plant compounds as anti-biofilm agents against Escherichia coli O157:H7 biofilm

Rohatgi, Anuj; Gupta, Pratima

doi:10.1016/j.meegid.2021.105055

Cited by 21 publications

(10 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phytochemicals like flavonoids have been used to prevent the formation of biofilm of seropathotype E. coli O157:H7 (STEC) by inhibiting the expression of locomotive surface assembly fimbriae. Flavonoid phloretin obtained from apple showed significant inhibition of biofilm of STEC at concentration of 50 μg/ml, confirmed by both genomic qRT-PCR analysis as well as electron microscope studies [49]. Similarly, Ginkgolic acid obtained from Ginkgo biloba and naringenin present in grape seed exhibited significant inhibition of STEC biofilm by the downregulation of curli gene.…”

Section: Natural Productsmentioning

confidence: 58%

See 1 more Smart Citation

Current Treatment Strategies Against Multidrug-Resistant Bacteria: A Review

et al. 2022

View full text Add to dashboard Cite

There are several bacteria called superbugs that are resistant to multiple antibiotics which can be life threatening specially for critically ill and hospitalized patients. This article provides up-to-date treatment strategies employed against some major superbugs, like methicillin-resistant Staphylococcus aureus, carbapenem-resistant Enterobacteriaceae, vancomycin-resistant Enterococcus, multidrug-resistant Pseudomonas aeruginosa, and multidrug-resistant Escherichia coli. The pathogen-directed therapeutics decrease the toxicity of bacteria by altering their virulence factors by specific processes. On the other hand, the host-directed therapeutics limits these superbugs by modulating immune cells, enhancing host cell functions, and modifying disease pathology. Several new antibiotics against the global priority superbugs are coming to the market or are in the clinical development phase. Medicinal plants possessing potent secondary metabolites can play a key role in the treatment against these superbugs. Nanotechnology has also emerged as a promising option for combatting them. There is urgent need to continuously figure out the best possible treatment strategy against these superbugs as resistance can also be developed against the new and upcoming antibiotics in future. Rational use of antibiotics and maintenance of proper hygiene must be practiced among patients.

show abstract

Section: Natural Productsmentioning

confidence: 58%

“…The polyphenol trans-resveratrol obtained from grape seeds also exhibited antibiofilm of STEC effect by similar downregulating of curli gene expression. Transcriptional assay indicates trans-resveratrol at the dose of 10 μg/ml prevented the adherence of E. coli cell onto human epithelial tissue [49].…”

Section: Natural Productsmentioning

confidence: 99%

Current Treatment Strategies Against Multidrug-Resistant Bacteria: A Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In this respect, the materials studied demonstrate their bacterial efficacy with E. coli and Listeria monocytogenes bacteria belonging to the biofilm-forming microbiota, according to Rohatgi et al [ 67 ] biofilm development includes four main stages: (i) reversible adhesion; (ii) irreversible adhesion and early structural development; (iii) maturation of the biofilm; and (iv) dispersal of the cells; this mechanism promotes surface adhesion, fostering infections. Some studies [ 68 , 69 ] have observed the presence of microbes in the form of biofilms in plastics, which is why the study of PLA/R1, PLA/R2, PLA/S1 and PLA/S2 compounds for surface disinfection is of functionality as a final product, which promotes the reduction of infections on surfaces.…”

Section: Resultsmentioning

confidence: 99%

Preliminary Study of the Bactericide Properties of Biodegradable Polymers (PLA) with Metal Additives for 3D Printing Applications

et al. 2023

View full text Add to dashboard Cite

Plastic is a highly used material in various sectors. Due to its plentiful availability in the environment, microorganism surface contamination is a risk. The aim of this work is to achieve bactericidal capacity in plastics that reduces the microorganism’s colonization risk and, consequently, reduces the chances of having an infection with E. coli and Listeria monocytogenes bacteria. Using polylactic acid (PLA) as the polymeric matrix, mixtures in concentrations of metal additive of ions of silver (Ag) R148 and S254 in 1% and 2% have been studied and manufactured. The materials are developed on an industrial scale through a process that proceeds as follows: (I) a mixture of polymer and additive in a double-screw compounder to obtain the compound in different concentrations, (II) the manufacture of filaments with a single-screw extruder, (III) 3D printing parts. Therefore, materials are evaluated in the form of powder, pellets and printed pieces to ensure their antibacterial effectiveness throughout the manufacturing process. The results of the research show antibacterial effectiveness for E. coli and Listeria monocytogenes of metal additives and polymeric compounds for all manufacturing phases on an industrial scale, with the effectiveness for additive R148 predominating at a concentration of 2%, demonstrating its microbial efficacy on surfaces with potential application in medicine.

show abstract

“…The pure form of AKBA inhibited S. epidermidis biofilm formation (MBIC50) at a concentration of 32 mg/L [71]. The high drug resistance of E. coli is due to the horizontal gene transfer, the ability of the microorganism to grow in the form of a biofilm, and the natural evolution of survival genes [15].…”

Section: Resultsmentioning

confidence: 99%

“…The active components of essential oils include terpenes, with a pentacarbon isoprene unit [14]. Terpenes are metabolized by the mevalonate pathway and control the expression of inflammatory genes [15].…”

Section: Introductionmentioning

confidence: 99%

Boswellic Acids as Effective Antibacterial Antibiofilm Agents

et al. 2022

View full text Add to dashboard Cite

Boswellic acids are biologically active pentacyclic terpenoid compounds derived from Boswellia sp. plants. Extracts containing these acids have a number of positive effects on human health, especially in the treatment of inflammation, arthritis, or asthma. With increasing resistance to common antibiotics, boswellic acid-containing extracts could serve as an alternative or work in synergy with commonly available preparations. This study aims to determine the effect of boswellic acids on suspension cells and biofilms of Staphylococcus epidermidis, Enterococcus faecalis, and Escherichia coli. The antimicrobial and antibiofilm effect found was compared with commonly available antibiotics to control these undesirable microorganisms. The synergistic effect of boswellic acids and common antibiotics on the growth of these microorganisms was also determined. All tested microorganisms showed a positive additive effect of antibiotics and boswellic acid extract. The most significant effect was found in Enterococcus faecalis ATCC 29212 in a combination of 0.2 × MIC80 erythromycin (0.2 mg/L) and 0.8 × MIC80 boswellic acid extract (16 mg/L).

show abstract

Natural and synthetic plant compounds as anti-biofilm agents against Escherichia coli O157:H7 biofilm

Cited by 21 publications

References 57 publications

Current Treatment Strategies Against Multidrug-Resistant Bacteria: A Review

Current Treatment Strategies Against Multidrug-Resistant Bacteria: A Review

Preliminary Study of the Bactericide Properties of Biodegradable Polymers (PLA) with Metal Additives for 3D Printing Applications

Boswellic Acids as Effective Antibacterial Antibiofilm Agents

Contact Info

Product

Resources

About