Boswellic Acids as Effective Antibacterial Antibiofilm Agents

Jaroš, Petr; Timkina, Elizaveta; Michailidu, Jana; Maršík, Dominik; Kulišová, Markéta; Kolouchová, Irena; Demnerová, Kateřina

doi:10.3390/molecules27123795

Cited by 10 publications

(3 citation statements)

References 88 publications

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“…serrata extract exhibits strong antibacterial effects, often ascribed to the presence of phenolic acids (24). Additionally, the ability to inhibit the formation of bacterial biofilm is attributed to the high concentration of terpenes in B. serrata extracts (25). A target-based screening of 664 natural compounds identified three BAs as inhibitors against MurA Escherichia coli, with an IC 50 7-11 µM (26).…”

Section: Multi-target Effects Of Boswellic Acidsmentioning

confidence: 99%

From Preclinical to Clinical Evidence: Exploring the Multiple Perspectives and Healing Power of Boswellia Serrata Roxb. Ex Colebr

Biagi,

Sarill,

Collotta

et al. 2023

Pharm Adv

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Boswellia serrata Roxb. ex Colebr. is a species belonging to the Burseraceae family, typical of dry environments of the Indian region. The oil-gum-resin, obtained from the trunk and thick branches, is known in phytotherapy for the volatile fraction which contains up to 70% terpenes. The most important and characteristic constituents are represented by pentacyclic triterpenes, named boswellic acids. B. serrata is known for multiple beneficial effects, mainly correlated to anti-inflammatory activity. This review aims to provide a comprehensive overview on the activities and potential applications of B. serrata based on clinical and preclinical evidence. An up-to-date literature review of preclinical and clinical studies related to the applications of B. serrata preparations in different pathological conditions was conducted using the main databases of scientific literature. A body of evidence point out the role of B. serrata extracts and its active constituents in the treatment of several inflammatory diseases. In particular, clinical trials revealed its use as a topical remedy of skin diseases, such as eczema and psoriasis, and internally in the treatment of asthma, intestinal and osteoarticular inflammatory diseases. Preclinical findings highlighted the positive effects of B. serrata extracts in cardiovascular and neurodegenerative diseases, and in cancer. Finally, B. serrata finds application as a feed additive in veterinary use. Although some limitations must be overcome, such as poor bioavailability, evidence supports that B. serrata is a promising medicinal plant. Furthermore, the use of B. serrata appears to have a favorable toxicological profile, but caution may be necessary regarding potential botanical-drug interactions.

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Section: Multi-target Effects Of Boswellic Acidsmentioning

confidence: 99%

From Preclinical to Clinical Evidence: Exploring the Multiple Perspectives and Healing Power of Boswellia Serrata Roxb. Ex Colebr

Biagi,

Sarill,

Collotta

et al. 2023

Pharm Adv

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show abstract

“…BSE, an oleogum resin of Indian frankincense, mainly employed in traditional Asiatic medicine, has recently gained growing popularity in the phytochemical-based management of a variety of inflammatory diseases (such as arthritis, osteoarthritis, inflammatory bowel disease, allergy, and asthma) [ 1 , 2 ]. In addition, recent studies have evidenced also the potential antimicrobial activity of the extract [ 3 , 4 ]. The main active compounds contained in BSE are pentacyclic triterpenic acids, called boswellic acids (BAs), which are considered the main agents responsible for the anti-inflammatory activity of the resin.…”

Section: Introductionmentioning

confidence: 99%

Development, Analytical Characterization, and Bioactivity Evaluation of Boswellia serrata Extract-Layered Double Hydroxide Hybrid Composites

Cometa,

Busto,

Castellaneta

et al. 2023

Molecules

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Boswellia serrata Roxb. extract (BSE), rich in boswellic acids, is well known as a potent anti-inflammatory natural drug. However, due to its limited aqueous solubility, BSE inclusion into an appropriate carrier, capable of improving its release in the biological target, would be highly desirable. Starting with this requirement, new hybrid composites based on the inclusion of BSE in a lamellar solid layered double hydroxide (LDH), i.e., magnesium aluminum carbonate, were developed and characterized in the present work. The adopted LDH exhibited a layered crystal structure, comprising positively charged hydroxide layers and interlayers composed of carbonate anions and water molecules; thus, it was expected to embed negatively charged boswellic acids. In the present case, a calcination process was also adopted on the LDH to increase organic acid loading, based on the replacement of the original inorganic anions. An accurate investigation was carried out by TGA, PXRD, FT-IR/ATR, XPS, SEM, and LC-MS to ascertain the nature, interaction, and quantification of the active molecules of the vegetal extract loaded in the developed hybrid materials. As a result, the significant disruption of the original layered structure was observed in the LDH subjected to calcination (LDHc), and this material was able to include a higher amount of organic acids when its composite with BSE was prepared. However, in vitro tests on the composites’ bioactivity, expressed in terms of antimicrobial and anti-inflammatory activity, evidenced LDH–BSE as a better material compared to BSE and to LDHc–BSE, thus suggesting that, although the embedded organic acid amount was lower, they could be more available since they were not firmly bound to the clay. The composite was able to significantly decrease the number of viable pathogens such as Escherichia coli and Staphylococcus aureus, as well as the internalization of toxic active species into human cells imposing oxidative stress, in comparison to the BSE.

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“…Boswellia serrata extract (BSE), an oleogum resin of Indian Frankincense, mainly employed in traditional Asiatic medicine, has recently gained growing popularity in the phytochemical-based management of a variety of inflammatory diseases (such as arthritis, osteoarthritis, inflammatory bowel disease, allergy, and asthma) [1,2]. In addition, recent studies evidenced also a potential antimicrobial activity of the extract [3,4]. The main active compounds contained in BSE are pentacyclic triterpenic acids, called boswellic acids (BAs), which are considered the main responsible for the anti-inflammatory activity of the resin.…”

Section: Introductionmentioning

confidence: 99%

Development, Analytical Characterization, and Bioactivity Evaluation of <em>Boswellia Serrata </em>Extract-Layered Double Hydroxide Hybrid Composites

Cometa¹,

Busto²,

Castellaneta³

et al. 2023

Preprint

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New hybrid composites based on the inclusion of a vegetal extract, i.e., Boswellia Serrata extract (BSE), rich in boswellic acids, well known as a potent anti-inflammatory natural drug, in a lamellar solid layered double hydroxide (LDH), i.e. a Magnesium Aluminum Carbonate, were developed and characterized in the present work. The adopted LDH exhibits a layered crystal structure, comprised of positively charged hydroxide layers and interlayers composed of carbonate anions and water molecules, thus it was expected to embed negatively charged boswellic acids. In the present case, a calcination process was also adopted on LDH to increase organic acids loading, based on the replacement of original inorganic anions. An accurate investigation was carried out by TGA, PXRD, FT-IR/ATR, XPS and LC-MS to ascertain the nature, interaction, and quantifica-tion of the active molecules of the vegetal extract loaded in the developed hybrid materials. As a result, a significant disruption of the original layered structure was observed in LDH subjected to calcination (LDHc), and this material was able to include a higher amount of organic acids when its composite with BSE was prepared. However, in vitro tests on composites bioactivity, expressed in terms of antimicrobial and anti-inflammatory activity, evidenced LDH-BSE as a better material compared to BSE and to LDHc-BSE, thus suggesting that, though the embedded organic acids amount was lower, they could be more available since not firmly bound to the clay. The composite was able to significantly decrease the number of viable pathogens such as Escherichia Coli and Staphylococcus aureus, as well as the internalization of toxic active species into human cells imposed to oxidative stress in comparison to the BSE.

show abstract

Boswellic Acids as Effective Antibacterial Antibiofilm Agents

Cited by 10 publications

References 88 publications

From Preclinical to Clinical Evidence: Exploring the Multiple Perspectives and Healing Power of Boswellia Serrata Roxb. Ex Colebr

From Preclinical to Clinical Evidence: Exploring the Multiple Perspectives and Healing Power of Boswellia Serrata Roxb. Ex Colebr

Development, Analytical Characterization, and Bioactivity Evaluation of Boswellia serrata Extract-Layered Double Hydroxide Hybrid Composites

Development, Analytical Characterization, and Bioactivity Evaluation of <em>Boswellia Serrata </em>Extract-Layered Double Hydroxide Hybrid Composites

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