Nasopharyngeal carcinoma in children: Review of 16 cases

Jereb, Berta; Ünal, Aslıhan Yürüktümen; Steinherz, P.; Huvos, Andrew G.

doi:10.1016/0360-3016(79)91017-4

Cited by 7 publications

(13 citation statements)

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“…However, randomised data in paediatric population comparing sequential CT + RT with concurrent treatment do not exist. Furthermore, although our study demonstrates a benefit to CT given sequentially relative to RT and is important to show that a greater total number of CT cycles correlates favourably with overall survival largely due to decreased distant failure, a standard protocol for paediatric NPC is yet to be identified, and more prospective randomised studies evaluating the addition of interferon or immunotherapy to CT and RT should be performed (7,23,36,(38)(39)(40)(41).…”

Section: Discussionmentioning

confidence: 96%

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The efficiency of different chemoradiotherapy regimens in patients with paediatric nasopharynx cancer: review of 46 cases

Bakkal¹,

Kaya²,

Berberoĝlu

et al. 2006

International Journal of Clinical Practice

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The purpose of this study was to evaluate the role of combined modality treatment in patients with paediatric nasopharynx cancer (NPC). Forty-six patients with paediatric NPC were retrospectively analysed. Forty-four of 46 patients received combined modality treatment. Five-year overall survival and progression-free survivals were 70% and 72% for the whole group, and only three of 46 patients had loco-regional relapse. Complete remission was obtained in 18 of 45 patients (40%), and the overall survival (94% vs. 62% and 19%, p = 0.0009) and disease-free survivals (93% vs. 70% and 16%, p = 0.0002) were significantly better in complete responders when compared with the patients who had partial response or stable disease. The 5-year overall survival and disease-free survivals of the patients who received neoadjuvant chemotherapy (CT) and radiotherapy (RT) followed by CT were superior to the other groups (77% and 80%, respectively). The number of total CT cycles (p = 0.0001), nodal stage (p = 0.05) and treatment response (p = 0.0009) were significant prognostic factors for overall survival. The treatment type (p = 0.02), the number of total CT cycles (p = 0.0006), nodal stage (p = 0.05) and treatment response (p = 0.0002) were found as significant prognostic factors for disease-free survival. The survival of patients receiving six or more CT cycles was also significantly better than that of patients receiving less than six cycles (p = 0.0001). In patients with locally advanced paediatric NPC, CT should be added to RT to improve outcome. However, a standard protocol is yet to be identified, and further studies evaluating the addition of interferon or immunotherapy to CT and RT shall be performed.

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Section: Discussionmentioning

confidence: 96%

“…[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]] and treatment response [p ¼ 0.04, HR ¼ 0.09 (95% CI 0.009-0.82)] were significant prognostic factors in multivariate analysis.…”

Section: Prognostic Factorsmentioning

confidence: 99%

The efficiency of different chemoradiotherapy regimens in patients with paediatric nasopharynx cancer: review of 46 cases

Bakkal¹,

Kaya²,

Berberoĝlu

et al. 2006

International Journal of Clinical Practice

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“…It most often presents as undifferentiated type and is usually associated with locoregionally advanced disease [8][9][10][11][12][13]. Published clinical studies dealing with children and adolescents with nasopharyngeal carcinoma consist of a retrospective review of patients managed without uniform treatment modalities and accrued over long periods; therefore, reported results regarding survival have been conflicting [4,[8][9][10][11][12][13][14][15][16][17][18][19]. This study reviews the authors' experience in the management and outcome of nasopharyngeal carcinoma in childhood and adolescence.…”

Section: Introductionmentioning

confidence: 99%

“…Although the incidence varies greatly according to racial and geographical factors, it accounts for 1-3% of all malignant tumors and 20-50% of all primary nasopharyngeal malignant tumors in this age group [1][2][3][4][5][6][7]. It most often presents as undifferentiated type and is usually associated with locoregionally advanced disease [8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Nasopharyngeal carcinoma in childhood and adolescence

Serin

Erkal

Elhan

et al. 1998

Med. Pediatr. Oncol.

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Background This study reviews the authors' experience from 1979 through 1996 in the management and outcome of 56 patients with nasopharyngeal carcinoma who were under 20 years of age. Procedure There were 33 males and 23 females, their ages ranging from 7 to 19 years (median: 16 years). Forty patients had World Health Organization type III carcinomas, 16 had T4 tumors, 41 had metastatic cervical lymph nodes, and 50 were at stage III or stage IV. Thirty‐two patients were treated with radiation therapy alone and 24 with the addition of chemotherapy. Cumulative radiation dose to the primary tumor ranged from 18 to 70 Gy (median: 66 Gy) and radiation dose to metastatic cervical lymph nodes ranged from 18 to 70 Gy (median: 66 Gy). Results Follow‐up ranged from 0.1 to 16.8 years (mean: 9 years). Locoregional tumoral complete response was achieved in 49 patients. Locoregional tumoral failure was observed in 12 patients and systemic failure in 11. Overall, locoregional failure‐free, metastases‐free, and disease‐free survival rates at 5 years were 49%, 62%, 79%, and 47%, respectively, for the entire group of patients, 42%, 61%, 72%, and 42%, respectively, for patients treated with radiation therapy alone, and 58%, 63%, 87%, and 54%, respectively, for patients treated with the addition of chemotherapy. Advanced T‐stage and lower radiation doses worsened locoregional failure‐free survival, whereas advanced N‐stage and exclusion of chemotherapy worsened metastases‐free survival. Conclusions In children and adolescents with nasopharyngeal carcinoma, radiation therapy alone results in an improved locoregional tumoral response rate and a reduced locoregional tumoral failure rate at higher radiation doses, while the addition of chemotherapy results in a reduced systemic failure rate. Med. Pediatr. Oncol. 31:498–505, 1998. © 1998 Wiley‐Liss, Inc.

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“…The first group's manuscripts typically included few patients, with inadequate locoregional and distant staging, and with suboptimal treatment modalities. 3,17,18,[25][26][27][28][29] Results of these manuscripts generally proposed the use of total tumor doses in the range of 35 to 86 Gy and point out the need for effective systemic treatment in addition to radiotherapy. The second group of manuscripts were published in 1990s, with better local and systemic staging of the disease and improved treatment parameters.…”

Section: Treatment Of Pediatric Nasopharyngeal Cancermentioning

confidence: 99%