Nasopharyngeal carcinoma in childhood and adolescence

Mertens, Rolf; Granzen, Bernd; Lassay, Lisa; Gademann, G.; Hess, Clemens F.; Heimann, G.

doi:10.1002/(sici)1097-0142(19970901)80:5<951::aid-cncr18>3.3.co;2-n

Cited by 12 publications

(5 citation statements)

References 4 publications

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“…In a multicentre prospective study by Mertens et al (28), 22 patients with advanced-stage paediatric NPC were treated with neoadjuvant CT (cisplatin + 5-FU + methotrexate), 60 Gy RT and interferon-beta (10 unit ⁄ kg, three times weekly, for 6 months). At a median follow-up of 62 months, the disease-free survival rate was found as 91%.…”

Section: Discussionmentioning

confidence: 99%

The efficiency of different chemoradiotherapy regimens in patients with paediatric nasopharynx cancer: review of 46 cases

Bakkal¹,

Kaya²,

Berberoĝlu

et al. 2006

International Journal of Clinical Practice

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The purpose of this study was to evaluate the role of combined modality treatment in patients with paediatric nasopharynx cancer (NPC). Forty-six patients with paediatric NPC were retrospectively analysed. Forty-four of 46 patients received combined modality treatment. Five-year overall survival and progression-free survivals were 70% and 72% for the whole group, and only three of 46 patients had loco-regional relapse. Complete remission was obtained in 18 of 45 patients (40%), and the overall survival (94% vs. 62% and 19%, p = 0.0009) and disease-free survivals (93% vs. 70% and 16%, p = 0.0002) were significantly better in complete responders when compared with the patients who had partial response or stable disease. The 5-year overall survival and disease-free survivals of the patients who received neoadjuvant chemotherapy (CT) and radiotherapy (RT) followed by CT were superior to the other groups (77% and 80%, respectively). The number of total CT cycles (p = 0.0001), nodal stage (p = 0.05) and treatment response (p = 0.0009) were significant prognostic factors for overall survival. The treatment type (p = 0.02), the number of total CT cycles (p = 0.0006), nodal stage (p = 0.05) and treatment response (p = 0.0002) were found as significant prognostic factors for disease-free survival. The survival of patients receiving six or more CT cycles was also significantly better than that of patients receiving less than six cycles (p = 0.0001). In patients with locally advanced paediatric NPC, CT should be added to RT to improve outcome. However, a standard protocol is yet to be identified, and further studies evaluating the addition of interferon or immunotherapy to CT and RT shall be performed.

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Section: Discussionmentioning

confidence: 99%

The efficiency of different chemoradiotherapy regimens in patients with paediatric nasopharynx cancer: review of 46 cases

Bakkal¹,

Kaya²,

Berberoĝlu

et al. 2006

International Journal of Clinical Practice

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“…Acute toxicity due to therapy was tolerable. 3,4 Due to the low incidence of these tumors in children, it is difficult to obtain consistent information on NPC therapy in the young. N asopharyngeal carcinoma (NPC) is a malignant disease with a variable range of incidence depending on age, geographic place, race, and Epstein-Barr virus (EBV) exposure.…”

Section: Resultsmentioning

confidence: 99%

“…4,22 The relation of undifferentiated NPC with EBV has led Mertens et al to design a treatment protocol with a prolonged therapy of recombinant ␤-interferon during 6 months. 3 We detected the EBV in all assessable tumor tissue samples: all of them were positive by ISH for EBER and LMP-1. The constant presence of LMP-1, oncogenic EBV associated protein, proves that this agent is tightly involved in NPC genesis.…”

Section: Discussionmentioning

confidence: 96%

“…3,[5][6][7][8][9] The purpose of this report was to analyze features at onset, treatment results, and outcome of children and adolescents with NPC followed in our hospital since 1988. But in recent years, chemotherapy combined with radiotherapy has been yielding better results, with significant disease free survival improvement in children and young adults in whom the undifferentiated variant is predominant.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3]5 Now it seems that the combination of radiotherapy with systemic chemotherapy yields better disease free survival results. With this approach, nearly 50% of patients developed distant metastases.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Nasopharyngeal carcinoma in childhood and adolescence

Zubizarreta

D'Antonio

Raslawski

et al. 2000

Cancer

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Prognostic factors and long‐term outcomes of childhood nasopharyngeal carcinoma

Cheuk

Billups

Martin

et al. 2010

Cancer

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BACKGROUND:The authors studied the survival and long-term morbidities of children with nasopharyngeal carcinoma (NPC). METHODS: This was a retrospective review of children with NPC who were treated at St. Jude Children's Research Hospital between 1961 and 2004. Prognostic factors and long term effects of therapy were analyzed. RESULTS: Fifty-nine patients (median age, 14.1 years) were identified. Most were male (66.1%) and black (54.2%) and had lymphoepithelioma (93.2%). Thirty-five patients had stage IV disease (59.3%), 20 patients had stage III disease (33.9%), and 4 patients had stage II disease (6.8%). All patients received radiotherapy (RT) to the primary tumor, and most received cervical RT (98.3%) and chemotherapy (88.1%). The 15-year survival and event-free survival (EFS) rates were 67.2% AE 7.5% and 63.5% AE 7.8%, respectively. Five patients (8.5%) developed subsequent malignancies 8.6 to 27 years after NPC diagnosis. EFS was improved in patients who were diagnosed after 1980 (74.8% AE 10% vs 45.5% AE 10.1%; P ¼ .031), in patients who had stage III disease compared with patients who had stage IV disease (79.3% AE 9.6% vs 56.2% AE 11.8%; P ¼ .049), in patients who received cisplatin (81% AE 10.7% vs 45.8% AE 9.7%; P ¼ .013), and in patients who received !50 grays of RT (71.4% AE 9.3% vs 43.8% AE 11.6%; P ¼ .048). White patients had higher distant failure rates than black patients (41.7% AE 10.4% vs 15.6 AE 6.5%; P ¼ .045). The 15-year cumulative incidence (CI) of any morbidity was 83.7% AE 5.4%, the CI of sensorineural hearing loss was 52.9% AE 6.7%, the CI of primary hypothyroidism was 42.7% AE 6.6%, and the CI of growth hormone deficiency (GHD) was 14.1% AE 4.7%. Dose-response relations were observed between the RT dose and primary hypothyroidism and GHD. CONCLUSIONS: The outcome of children with NPC improved over the past 4 decades with the use of cisplatin-based chemotherapy and higher RT doses. However, many survivors had long-term treatment-related morbidities.

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Nasopharyngeal carcinoma in childhood and adolescence

Cited by 12 publications

References 4 publications

The efficiency of different chemoradiotherapy regimens in patients with paediatric nasopharynx cancer: review of 46 cases

The efficiency of different chemoradiotherapy regimens in patients with paediatric nasopharynx cancer: review of 46 cases

Nasopharyngeal carcinoma in childhood and adolescence

Prognostic factors and long‐term outcomes of childhood nasopharyngeal carcinoma

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