Nasal polyposis: Prevalence of positive food and inhalant skin tests

Collins, Melanie M.; Loughran, Sean; Davidson, Pauline; Wilson, Janet A.

doi:10.1016/j.otohns.2006.07.005

Cited by 37 publications

(30 citation statements)

References 13 publications

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“…Our results are consistent with previous findings of a high prevalence of food sensitization in chronic sinusitis patients [4,5,7]. Eighty-four percent of our MRCRS patients had at least one positive serology test for food sensitization; however, we could not find any significant differences in the prevalence, type of food, number of food sensitizations and severity between CRSwNP and CRSsNP.…”

Section: Discussionsupporting

confidence: 92%

“…Collins et al [5] found patients with nasal polyposis were no more likely to react to skin prick tests for inhalant allergens than controls, but were twice as likely to have positive intradermal food tests. Furthermore, only half of the patients with nasal polyposis and controls with positive food sensitization also had positive inhalation sensitization.…”

Section: Discussionmentioning

confidence: 99%

“…Another study identified a significant difference in the prevalence of food allergy between CRSwNP patients and healthy controls, with the food allergy test being positive in 72% of patients with CRSwNP [5]. Lill et al [6] did not find such a high prevalence of food allergy among CRSwNP and suggested a positive role of milk allergy as a relevant pathogenetic entity in nasal polyposis.…”

Section: Introductionmentioning

confidence: 99%

“…Lill et al [6] did not find such a high prevalence of food allergy among CRSwNP and suggested a positive role of milk allergy as a relevant pathogenetic entity in nasal polyposis. Based on these significant differences in the prevalence of food sensitization between healthy volunteers and CRSwNP patients, these studies [4,5,7] assumed a possible role of food allergy in nasal polyp etiology; however, a third group representing CRSsNP should be evaluated before such an assumption can be confirmed. The aim of this study was to compare the prevalence of food sensitization in MRCRS patients with or without nasal polyposis.…”

Section: Introductionmentioning

confidence: 99%

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Food Sensitization in Medically Resistant Chronic Rhinosinusitis with or without Nasal Polyposis

Al‐Qudah¹

2016

Int Arch Allergy Immunol

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Background: Nasal polyposis is a common nasal mass with unknown etiology. It has been assumed that allergy predisposes to polyp formation. Our objective was to compare the prevalence of food sensitization in medically resistant chronic rhinosinusitis patients with or without nasal polyposis. Methods: One hundred and fifty-five patients who fulfilled the inclusion and exclusion criteria were incorporated into this study. The results of their total serum IgE and food-specific IgE levels were examined. Results: The average age was 33 years (± 13) with 96 males and 59 females. The percentage of patients in each group that had a positive result for at least one tested allergen was 84% (88 patients in the sinusitis without polyposis group and 42 patients in nasal polyposis group). Patients without nasal polyposis reacted to an average of 4.6 foodstuffs, whereas patients with nasal polyposis reacted to 4.1. Egg white, sheefish and cherry were the most common type of sensitized food. There were no significant differences in the prevalence, type, number of positive food allergens and class level between the two groups. Conclusions: Food sensitization is common in medically resistant chronic rhinosinusitis. Since food sensitization prevalence, type and severity do not significantly differ between the two groups studied, food atopy is unlikely to be a major factor in nasal polyposis pathogenesis.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Food Sensitization in Medically Resistant Chronic Rhinosinusitis with or without Nasal Polyposis

Al‐Qudah¹

2016

Int Arch Allergy Immunol

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“…Allergic CRSwNP showed a worse therapeutic response than non-allergic CRSwNP in patients treated with budesonide nasal spray (18). However, its underlying pathogenesis remains unclear (19). In the present study, 15 (22.1%) CRSwNP patients showed atopy, representing a higher incidence than that for healthy people.…”

Section: Discussionmentioning

confidence: 45%

Different roles of Staphylococcus aureus enterotoxin in different subtypes of nasal polyps

Cheng

Wang

2016

Experimental and Therapeutic Medicine

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Abstract. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease. The pathogenesis of CRSwNP remains unclear. This study was designed to investigate the role of inflammation and Staphylococcus aureus enterotoxin (SE) in this disease. The study included a total of 74 patients with CRSwNP and 6 controls. A serum Phadiatop assay was conducted to detect atopy status, and serum eosinophil cationic protein (ECP) and total immunoglobulin (Ig)E levels were determined using ELISA. SEA, SEB, total IgE, ECP and myeloperoxidase (MPO) levels in nasal tissue supernatant were measured using ELISA. The results indicated that 15 (22.1%) patients had systemic allergies. On the basis of the ECP/MPO ratio, the patients were divided into an eosinophilic CRSwNP group (n=18) and a non-eosinophilic CRSwNP group (n=56). The total ECP/MPO ratio was 0.572, with a notable bias toward neutrophilic inflammation. The supernatant ECP and MPO levels were elevated in the CRSwNP group compared with the control group, but no significant difference in the serum total IgE and ECP levels were observed between the CRSwNP and control groups. In addition, the non-eosinophilic and eosinophilic CRSwNP groups showed significant elevations in supernatant total IgE, SEA and SEB levels compared with the control group. Thus, it may be concluded that allergy is a common pathogenesis of CRSwNP, and neutrophilic inflammation is present in most Chinese CRSwNP patients. Additionally, local indicators reflect the inflammatory status more accurately than do serum indicators. SEs may act as an infection factor rather than as a superantigen in Chinese non-eosinophilic CRSwNP patients. Thus, long-term antibiotic therapy may be an option for Chinese non-eosinophilic CRSwNP patients.

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Surgical interventions for chronic rhinosinusitis with nasal polyps

Sharma

Lakhani

Rimmer

et al. 2014

Cochrane Database of Systematic Reviews

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Nasal polyposis: Prevalence of positive food and inhalant skin tests

Abstract: Evaluation of the allergic status of patients with polyposis is important. Dietary manipulation may be indicated, though its role needs further investigation.

Cited by 37 publications

References 13 publications

Food Sensitization in Medically Resistant Chronic Rhinosinusitis with or without Nasal Polyposis

Food Sensitization in Medically Resistant Chronic Rhinosinusitis with or without Nasal Polyposis

Different roles of Staphylococcus aureus enterotoxin in different subtypes of nasal polyps

Surgical interventions for chronic rhinosinusitis with nasal polyps

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